Quotulatiousness

July 29, 2013

“Junk food costs as little as $1.76 per 1,000 calories, whereas fresh veggies … cost more than 10 times as much”

Filed under: Economics, Food, Health, USA — Tags: , , , , — Nicholas @ 10:35

Making a case for the McDonald’s McDouble as the greatest food in human history:

What is “the cheapest, most nutritious and bountiful food that has ever existed in human history” Hint: It has 390 calories. It contains 23g, or half a daily serving, of protein, plus 7% of daily fiber, 20% of daily calcium and so on.

Also, you can get it in 14,000 locations in the US and it usually costs $1. Presenting one of the unsung wonders of modern life, the McDonald’s McDouble cheeseburger.

The argument above was made by a commenter on the Freakonomics blog run by economics writer Stephen Dubner and professor Steven Leavitt, who co-wrote the million-selling books on the hidden side of everything.

Dubner mischievously built an episode of his highly amusing weekly podcast around the debate. Many huffy back-to-the-earth types wrote in to suggest the alternative meal of boiled lentils. Great idea. Now go open a restaurant called McBoiled Lentils and see how many customers line up.

But we all know fast food makes us fat, right? Not necessarily. People who eat out tend to eat less at home that day in partial compensation; the net gain, according to a 2008 study out of Berkeley and Northwestern, is only about 24 calories a day.

The outraged replies to the notion of McDouble supremacy — if it’s not the cheapest, most nutritious and most bountiful food in human history, it has to be pretty close — comes from the usual coalition of class snobs, locavore foodies and militant anti-corporate types. I say usual because these people are forever proclaiming their support for the poor and for higher minimum wages that would supposedly benefit McDonald’s workers. But they’re completely heartless when it comes to the other side of the equation: cost.

Update, 30 July: Stephen Dubner notes that the Kyle Smith story has triggered “about one zillion” media requests for more comment on the original post, but that he’s too busy writing to take time out to respond.

July 22, 2013

Examining post-traumatic stress disorder

Filed under: Health, Military, USA — Tags: , , , — Nicholas @ 08:23

In the New Yorker, David J. Morris looks at the psychological chameleon we call PTSD:

As it is understood today, post-traumatic stress disorder is a grab bag of symptoms that emerges after experiencing trauma, like nearly dying or having one’s bodily integrity violated. It includes a persistent sense of hypervigilance and recurrent, intrusive memories of past traumatic events. In the worst cases, veterans with P.T.S.D. may hallucinate the voices of dead comrades, enemy combatants, or their commanding officers. A 1995 study of combat veterans with P.T.S.D. published in Traumatology found that sixty-five per cent of subjects reported hearing voices, including command hallucinations that they felt compelled to obey. As the psychiatrist Jonathan Shay, the author of Achilles in Vietnam: Combat Trauma and the Undoing of Character, put it, “P.T.S.D. can unfortunately mimic virtually any condition in psychiatry.”

But there are a growing number of psychiatrists and researchers who are challenging our understanding of P.T.S.D. — even its very nature as an ailment. Modern psychiatry, they argue, is locked into a mindset that systematically overdiagnoses P.T.S.D. without nurturing veterans’ ability to heal themselves. American culture, meanwhile, vacillates between elevated ideas of hero worship and victimhood in its conception of veterans, which can be destructive to the veterans themselves. One of the chief proponents of this school of thought is Ben Shephard, a leading British historian of military psychiatry. In his provocative book, A War of Nerves: Soldiers and Psychiatrists in the Twentieth Century, he describes a historical cycle that governs the treatment of war stress: “the problem is at first denied, then exaggerated, then understood, and finally, forgotten.” Shephard claims that the West, and America in particular, are deeply mired in the exaggeration phase of that cycle. These skeptics of the prevailing model of P.T.S.D. were described in Scientific American as a “broad array of experts indeed, giants of psychology, psychiatry and epidemiology.” One of the major tenets of this argument is a fact that, on its face, suggests that P.T.S.D. is a culturally determined phenomenon as well as a medical one: American veterans are 2.5 to four times more likely to be diagnosed with P.T.S.D. than British veterans.

[…]

As Jonathan Shay, the author of Achilles in Vietnam, shows in his follow-up, Odysseus in America: Combat Trauma and the Trials of Homecoming, while the problem of returning from war is one of humanity’s oldest struggles, the use of P.T.S.D. to frame a wide variety of traumatic experiences is a relatively recent development. The growing criticism of our current understanding of P.T.S.D. suggests that what was once ignored or treated as a failure of character — the soldier’s weakness — has now been medicalized to the exclusion of discussing its moral and spiritual dimensions. “It feels to me as if the U.S. civilian population has pathologized the veteran experience,” Elliott Woods, an Iraq veteran-turned-reporter, told me not long ago. “One well-intentioned person said to me the other day, ‘I can’t see how anyone could go to Iraq and not come back with P.T.S.D.’

H/T to Tim Harford for the link.

July 13, 2013

The state’s constant interest in what’s in your kid’s lunchbag

Filed under: Britain, Education, Health — Tags: , , — Nicholas @ 09:13

James Delingpole on the most recent “Nanny knows best” appointee hoping to dictate what the kids are going to eat for lunch:

“Mr Dimbleby”, it seems to me, is coming perilously close to suggesting that the decision as to what children eat at school should be a matter for the State rather than parents. Can he really believe this? Is there nothing about saying this sort of thing that makes him uneasy?

I mean sure, I agree with him on the principle that a good, well-prepared hot meal at lunchtime is probably more filling and nourishing than a packet-bread sandwich and a packet of crisps. Problem is, not all school canteens offer quite the same range and quality you might find in — oh, I don’t know, let’s pluck a random example from the air, shall we? — Bekynton.

Having put children through the state system myself I know whereof I speak. A new caterer arrived at my daughter’s primary school to much fanfare and for a while the food was great and most parents gratefully abandoned packed lunches (which, let me tell you, are a real hassle for a parent to prepare because they have to be done fresh in the morning when you’re already in a rush having breakfast and getting ready for the school run) and welcomed the new regime. But then standards began slipping to the point where my daughter (who, like a lot of children whose staple diet is gastro-porn TV programmes from the Great British Bake Off to Masterchef, genuinely cares about food) couldn’t eat the stuff any more. Again: is “Mr Dimbleby” seriously suggesting that schools should force children to go on eating in the canteen regardless of how disgusting they find the food?

You hear similar arguments from well-heeled progressive types on the school system generally. “If only public schools were abolished and all those pushy middle-class strivers were forced to put their children through the state system, standards would rise across the board.” Well, possibly. What would more likely happen is that all those scrubbed, diligent, nicely spoken, polite young poshos would be dragged down to the level of the lowest common denominator. And in any case it’s not an experiment which has any right being attempted anywhere in a Western notionally free-market economy. Why not? Because it’s illiberal bordering on the totalitarian, is why.

This is hardly a new topic … last year I said:

I remember what kind of crap my middle and high school cafeterias offered … and if I’d forgotten to bring a sandwich with me that day, going hungry always seemed like the better choice. The food on offer always seemed to manage the difficult stunt of being visually unappealing (sometimes being actually disgusting to look at), nutritionally inadequate, and either utterly flavourless (the better choice) or actively nasty. No wonder the best sellers in the cafeteria were the milk cartons (especially the chocolate milk), pop cans, potato chips, chocolate bars, and Vachon cakes (all of which were pre-packaged and relatively invulnerable to further processing).

July 3, 2013

US public opinion on abortion has been stable for decades

Filed under: Health, Law, Media, Politics, USA — Tags: , , , , — Nicholas @ 10:31

Nick Gillespie says the stability of beliefs on the topic of abortion is one of the most striking things about the whole debate:

So despite decades of polling data showing that large majorities of Americans believe abortion should be legal under some circumstances, you could be excused for thinking there are only two possible positions when it comes to terminating pregnancies: either all abortions should be allowed, or none should be.

Yet the most striking thing about attitudes toward abortion is how stable they’ve been over the 40 years since Roe v. Wade. Gallup has been tracking public sentiment on the matter since 1975, when 22 percent of Americans agreed that abortion should be illegal under any circumstances and 21 percent believed it should be legal under any circumstances. Those numbers are now 18 percent and 28 percent respectively. In 1975 54 percent believed abortion “should be legal only under certain circumstances.” The number is now 52 percent and has never gone above 61 percent or below 48 percent. Over the past 15 years, the number of Americans calling themselves “pro-life” and “pro-choice” has narrowed to a few points, with 48 percent identifying as pro-choice and 44 percent as pro-life (in 2011, those figures were basically flipped).

Official political stances on abortion are absolutely Manichaean, however, with the Republican Party and most of its leading figures stressing that life begins at conception, a belief that would outlaw virtually all abortions except those necessary to protect the health of the mother. The Democratic Party platform — and most of its highest-profile members, including President Barack Obama — “strongly and unequivocally supports” abortion at any time and for any reason during a pregnancy.

Most Americans reject such categorical, extreme views and instead offer conditional support for abortion depending on when it’s performed. Gallup found that while 61 percent of Americans think abortion for should mostly be legal in the first three months of pregnancy and 27 percent felt it should be legal in the second trimester, just 14 percent agreed it should be allowed on demand in the final three months.

Unlike their political representatives, then, Americans hold a far more nuanced view of abortion, and one that comports with the reality of the procedure. Of the roughly 1 million abortions performed a year in America, about 90 percent take place within the first 12 weeks of pregnancy and only 1 percent take place after 20 weeks (in fact, over the past decade, there has been a marked trend toward earlier abortions). That helps explain why 62 percent of Texans supported S.B. 5, the bill that Wendy Davis filibustered.

Update: You went full Satanist. Never go full Satanist:

Not that invoking Satan isn’t serious, but the response on Twitter included some great humor. A few of my favorites:


The Blaze noted:

Obviously, it is much more likely that the abortion supporters were chanting “Hail Satan!” to mock pro-lifers rather than actually hailing Lucifer, but anything is possible.

Ed Morrissey responded:

I’m certain that the intent was mockery. The overall effect of chanting “Hail Satan”? That’s another story, but one of those effects is surely clarity.

Right. Having been to Texas, I can assure you that the defense of “We were mocking Christians by invoking Satan,” might actually make things worse.

We’re just trying to raise your awareness…

Filed under: Health, Media, Politics — Tags: , , , , — Nicholas @ 09:44

… because we’re morally and ethically superior to you unwashed plebs:

Last Thursday was Post-Traumatic Stress Disorder Awareness Day. If you missed it, that’s probably because every week there are awareness days. We’re swamped by them. There are literally thousands of organisations whose mission is to raise our awareness. There is also a vast number of politicians, policymakers, experts, professionals, academics and earnest volunteers who are all devoted to the cause of raising awareness.

Those who set themselves up to raise the public’s awareness are not just providing information; they’re also making a statement about themselves, about who they are. They, unlike those who require their support, are aware. Awareness is presented as a state of being all of us should aspire to attain. In its common usage today, the term awareness resists any clear definitions. It is not simply about knowing or understanding. [. . .]

Campaigns designed to raise awareness are as much about advertising the status of the campaigners as they are about changing the outlook of a target audience. For example, advocates of breastfeeding produce literature that affirms the virtuous nature of their own lifestyles while also inviting those who have not seen the light to become aware. The very term ‘raising awareness’ involves drawing a distinction between those who are enlightened, who are aware of something, and those who are not. It draws attention to the fundamental contrast between those who know and those who are ignorant, between the morally superior and the morally inferior. So someone who allows his children to eat junk food is not only unaware and ignorant; he’s also morally questionable.

Awareness-raising campaigns impute to their advocates the values of intelligence, sensitivity, broadmindedness, sophistication and enlightenment. For that reason, the mission of raising awareness has become a key cultural resource for those who want to distinguish themselves from others. Awareness-raisers are invariably drawn towards inflating the behavioural and cultural distinctions between themselves and the rest of society; they are preoccupied with constructing a lifestyle that contrasts as sharply as possible to the lifestyles of their moral inferiors. What is really important about their lifestyles is not so much the values they exhort, but that they are different, in every detail, from the lives led by obese, junk-food eating, gas-guzzling, xenophobic and fundamentalist consumers of the tabloid press and junk culture.

Sociologically speaking, the act of raising awareness is really a claim for moral respect, and more importantly moral authority. The possession of awareness is a marker of superiority — and the absence of awareness is taken as a sign of inferiority. Those who refuse to ‘be aware’ are frequently morally condemned

June 27, 2013

Progress and regress in the pursuit of care for the mentally ill

Filed under: Government, Health, History, USA — Tags: , , — Nicholas @ 13:32

In City Journal, James Panero looks at the history of treatment of the mentally ill in America:

If it’s true that “men moralise among ruins,” as Benjamin Disraeli wrote, the ruins of America’s nineteenth-century mental institutions should invite some serious reflection. Built between 1850 and 1900, these crumbling edifices speak to our onetime dedication to caring for the mentally ill. Almost all were designed on the Kirkbride Plan, named for Pennsylvania physician Thomas Story Kirkbride, author of an influential treatise on the role of architecture and landscape in treating mental disorders. Even in their dilapidated state, it’s possible to see how the buildings, which followed a method of care called the “moral treatment,” gave the mentally ill a calming refuge from the gutters, jails, and almshouses that had been the default custodians of society’s “lunatics.”

Unfortunately, in the middle of the twentieth century, as asylums became grossly overcrowded and invasive treatments aroused public concern, the moral treatment came to seem immoral. The eventual result was the process known as deinstitutionalization, which steadily ejected patients from the asylums. Instead of liberating the mentally ill, however, deinstitutionalization left them — like the asylums that once sheltered them — in ruins. Many of today’s mentally ill have returned to pre-Kirkbride conditions and live on society’s margins, either sleeping on the streets or drifting among prisons, jails, welfare hotels, and outpatient facilities. As their diseases go untreated, they do significant harm to themselves and their families. Some go further, terrorizing communities with disorder and violence. Our failure to care for them recalls the inhumane era that preceded the rise of the state institutions. The time has come for new facilities and a new moral treatment.

[. . .]

At a time when the medical science of mental illness was in its infancy, the Kirkbride Plan created alternative, protected worlds for patients. It echoed many of today’s more holistic approaches to treatment by encouraging patients to participate in social activities, games, and crafts. Kirkbride institutions often sported their own baseball diamonds, golf courses, bakeries, bowling alleys, ice cream shops, dairy farms, gardens, and stages for plays and other performances.

But in the twentieth century, a shadow fell over the Kirkbride asylums, as doctors there began using more invasive procedures. The Austrian psychiatrist Manfred Sakel introduced insulin shock therapy, now known as insulin coma therapy, in the 1930s. Electroshock therapy arrived from Italy soon after. Both treatments induced seizures to alter brain chemistry in patients with depression and schizophrenia. In 1949, the Portuguese neuropsychiatrist Egas Moniz won a Nobel Prize for developing the frontal lobotomy, which he had invented in 1935. Walter Freeman, a clinical neurologist in Washington, D.C., further popularized the treatment through his own outpatient procedure, which came to be known as the transorbital, or “ice-pick,” lobotomy.

June 25, 2013

Portugal’s experience with drug decriminalization

Filed under: Europe, Health, Law, Liberty — Tags: , , , — Nicholas @ 14:38

The Cato Institute sent out a Twitter update, reminding everyone about the 2009 White Paper by Glenn Greenwald on how the Portuguese drug experiment played out after 2001:

On July 1, 2001, a nationwide law in Portugal took effect that decriminalized all drugs, including cocaine and heroin. Under the new legal framework, all drugs were “decriminalized,” not “legalized.” Thus, drug possession for personal use and drug usage itself are still legally prohibited, but violations of those prohibitions are deemed to be exclusively administrative violations and are removed completely from the criminal realm. Drug trafficking continues to be prosecuted as a criminal offense.

While other states in the European Union have developed various forms of de facto decriminalization — whereby substances perceived to be less serious (such as cannabis) rarely lead to criminal prosecution — Portugal remains the only EU member state with a law explicitly declaring drugs to be “decriminalized.” Because more than seven years have now elapsed since enactment of Portugal’s decriminalization system, there are ample data enabling its effects to be assessed.

Notably, decriminalization has become increasingly popular in Portugal since 2001. Except for some far-right politicians, very few domestic political factions are agitating for a repeal of the 2001 law. And while there is a widespread perception that bureaucratic changes need to be made to Portugal’s decriminalization framework to make it more efficient and effective, there is no real debate about whether drugs should once again be criminalized. More significantly, none of the nightmare scenarios touted by preenactment decriminalization opponents — from rampant increases in drug usage among the young to the transformation of Lisbon into a haven for “drug tourists” — has occurred.

The political consensus in favor of decriminalization is unsurprising in light of the relevant empirical data. Those data indicate that decriminalization has had no adverse effect on drug usage rates in Portugal, which, in numerous categories, are now among the lowest in the EU, particularly when compared with states with stringent criminalization regimes. Although postdecriminalization usage rates have remained roughly the same or even decreased slightly when compared with other EU states, drug-related pathologies — such as sexually transmitted diseases and deaths due to drug usage — have decreased dramatically. Drug policy experts attribute those positive trends to the enhanced ability of the Portuguese government to offer treatment programs to its citizens — enhancements made possible, for numerous reasons, by decriminalization.

June 24, 2013

Finally, a semi-rational explanation for the slow adoption of deodorant in Britain

Filed under: Britain, Health, History, Media — Tags: , , — Nicholas @ 11:57

Richard Smith talks about the British Medical Association’s “official” stance on heterosexual and homosexual “indulgences” from the 1950s on, and also explains why British use of deodorant always lagged the rest of the western world:

I was once responsible for Family Doctor Publications, which were a series of booklets owned by the BMA, had titles like You and Your Bowels, and sold in huge numbers in the 1950s because they were almost the only information on health available to the public. I was much amused that in the 50s the BMA agreed that the booklets could include advertising for cigarettes and alcohol, but under no circumstances could they advertise contraceptives. And at about the same time thousands of copies of one booklet had to be pulped because it seemed to accept the possibility of sex before marriage. Now I’ve learnt more about the prudishness and “severe, restrictive morality” of the BMA.

[. . .]

The BMA was also happy to ignore science and evidence when it launched into explanations of what at the time was perceived as “an epidemic of homosexuality.” “Many men see in homosexual practices as a way of satisfying their sexual desires without running the risks of sequelae of heterosexual intercourse. They believe, for example, that there is no danger of contracting venereal disease in homosexual activity. Other men adopt homosexual practices as a substitute for extramarital heterosexual intercourse because there is no fear of causing pregnancy or emotional complications as in the life of a woman.” The idea that “women” equals “emotional complications” was a very 50s idea.

It was unsurprising, thought the BMA, that the public would be hostile to homosexuals because of the propensity of its practitioners in “positions of authority to give preferential treatment to homosexuals or to require homosexual subjection as an expedient for promotion. The existence of practising homosexuals in the Church, Parliament, Civil Service, Armed Forces, Press, radio, stage and other institutions constitutes a special problem.” Medicine is conspicuously absent from that list. God (heterosexual, of course, even though capable of insemination without intercourse) forbid that the BMA would have homosexuals in its membership.

The BMA found sexual acts between men “repulsive” and that “homosexuals congregating blatantly in public houses, streets, and restaurants are an outrage to public decency. Effeminate men wearing make-up and using scent are objectionable to everybody.” Born in 1952 I was infused with this kind of thinking and didn’t use a deodorant until I was 45 for fear of what people might think. My father, born in 1922, didn’t like me to buy half a pint rather than a pint of beer in case I be thought homosexual.

Having made its position clear, the BMA concluded that “if degenerate sodomists” persist then “it would be in the public interest to deal with them in the same way as mentally deranged offenders.” In other words, commit them to state lunatic asylums.

June 21, 2013

The healing powers of silver

Filed under: Health, Science — Tags: , , , — Nicholas @ 09:01

In The Economist, some new ideas about silver:

Silver has long been known as more than bling. In the fifth century BC Hippocrates noted its ability to preserve food and water. In the late 19th century silver-nitrate eye drops were administered to newborns to prevent conjunctivitis (though this remedy has since been replaced with an antibiotic). Today silver is routinely found in wound dressings and catheters to treat or prevent infections. Yet, despite its widespread use, the source of silver’s antibacterial properties has remained shrouded in mystery.

Now Jose Morones-Ramirez, from Boston University, and colleagues think they may have cracked it. As they report in Science Translational Medicine, silver fights bacteria in a number of ways.

First, silver ions (as atoms stripped of some of their electrons are known) help, through a process known as the Fenton reaction, to convert hydrogen peroxide into molecules called hydroxyl radicals. Radicals are unstable and readily react with cellular components, damaging them. Indeed, an excess is thought to contribute to ageing-related illnesses in humans. However, the researchers found, concentrations of silver ions low enough to leave human cells unscathed nonetheless appear to wreak havoc on bacterial ones.

Using a dye that glows in the presence of hydroxyl radical, Dr Morones-Ramirez treated the bacterium Escherichia coli with silver nitrate (a source of silver ions). The E. coli glowed, and then promptly bit the dust. But when the bacteria were first bathed in a chemical which mops up the hydroxyl radicals, they survived. This points to silver’s effect on the production of hydroxide radicals as the explanation.

June 19, 2013

Examining Vermouth’s claim to being the “oldest wine in the world”

Filed under: Greece, Health, History, Italy, Middle East, Wine — Tags: , — Nicholas @ 08:13

History Today linked to an article in their archives from 1975 from Pamela Vandyke Price discussing the ancient provenance of Vermouth:

When the great vermouth establishments refer to their product as ‘the oldest form of wine in the world’, they are not exaggerating. If we could travel in time, we might find many of the wines praised in antiquity to be harsh, sour and coarse to our palates, but the ‘aromatized wine’ that we know as vermouth would then have existed and, even if we drank it for medicinal or preventive reasons rather than for enjoyment, we could recognise it and relate it to the vermouths of today.

Vermouth can be, and often is, made wherever wine is made. The ancient Egyptians used both wine and beer, plus juniper, frankincense, celery, lotus leaves and honey, in the treatment of certain ailments; and it is by a method of infusion, maceration, distillation, or two or all three of these processes that, essentially, vermouth is made today. In Book IV of the Odyssey, Helen throws a drug given to her by an Egyptian lady into the bowl in which the wine is to be mixed and diluted before dinner; this ‘had the power of robbing grief and anger of their sting and banishing all painful memories’ — an efficacious aperitif, assuring good digestion. At the end of the third millennium B.C. what is perhaps the first written doctor’s prescription is recorded in cuneiform script on a tablet from the Sumerian city of Nippur — a physician notes that certain powders should be infused with a type of wine.

[. . .]

Other families in the drink business were quick to see the possibilities for vermouth, setting up in Turin, Marseilles and Sete (again in proximity to mountain herbs and a quantity of wine), and in Chambray. Many of them are still family concerns, even though they are great empires of the drink business. Martini & Rossi, who were founded about 1840, replaced a much older concern making vermouths and liqueurs at Pessione, near Turin (the head of that firm was the grandfather of Giovanni Angelli, founder of Fiat); the superb museum now established alongside the Pessione installations is a necessary detour for anyone interested in the history of wine from the earliest times.

The Cinzano family began in the drink business in the sixteenth century, and in 1757 the brothers Carlo Stefano and Giovanni Giacomo were invested as Master Distillers in Turin; today their business is gigantic, including, among other things, the Florio concern at Marsala, (itself including the former cantinas of Ingham and Woodhouse). Louis Noilly, in business at the beginning of the nineteenth century in Lyons, set up in the vermouth trade with his son-in-law, Claudius Prat and they enjoyed so much success that by 1843 they moved their headquarters to Marseilles. Madame Josephine Prat, who ran the business after the deaths of the two founders, was succeeded by her two children; and her granddaughter, Vicomtesse Vigier, who entered the firm before 1939, directed it until 1970 when she died, over a hundred years old.

It seems a little odd that, with so many modifications of wine-making and changes in the tastes of drinkers, aromatized wine should still be in demand. But, in fact, it is increasingly so. Whenever people order a straight vermouth they are ordering the oldest wine in the world.

June 16, 2013

Recognizing a sociopath

Filed under: Books, Health, Media — Tags: , , — Nicholas @ 10:06

At Marginal Revolution, Tyler Cowen discusses a book that may or may not be a dependable guide to sociopaths:

The author argues that sociopaths are often very smart, have a lot of natural cognitive advantages in manipulating data, and are frequently sought out as friends for their ability to appeal to others. It is claimed that, ceteris paribus, we will stick with the sociopath buddies, as we are quite ready to use sociopaths to suit our own ends, justly or not. It is claimed that for all of their flaws, many but not all sociopaths are capable of understanding what is in essence the contractarian case for being moral — rational self-interest — and sticking with it. Citing some research in the area (pdf), the author speculates that sociopaths may have an “attention bottleneck,” so they do not receive the cognitive emotional and moral feedback which others do, unless they decide very consciously to focus on a potential emotion. For sociopaths, top down processing of emotions is not automatic.

We even learn that (supposedly) sociopaths are often infovores. It seems many but not all sociopaths are relatively conscientious, and the author of this book (supposedly) teaches Sunday school and tithes ten percent to the church. It just so happens sociopaths sometimes think about killing or destroying other people, without feeling much in the way of remorse.

[. . .]

I cannot evaluate the scientific claims in this book, and would I trust the literature on sociopaths anyway, given that the author claims it is subject to the severe selection bias of having more access to the sociopathic losers and criminals? (I buy this argument, by the way.) It did occur to me however, that for the rehabilitation of sociopaths, whether through books or other means, perhaps they should consider…a rebranding exercise? But wait, “Sorry, I could not find synonyms for ‘sociopath’.”

If nothing else, this book will wake you up as to how little you (probably) know about sociopaths.

June 15, 2013

Ontario’s abusive relationship with sex ed

Filed under: Cancon, Education, Health, Media — Tags: , , , , , — Nicholas @ 10:31

In Maclean’s, Emma Teitel talks about the failure of Ontario’s sex-ed classes to keep up with the times:

In the fifth grade, my friends and I had a special afternoon tradition. When school let out at 3:30, we would walk to Katherine’s house (a pseudonym), raid her fridge, go upstairs to her bedroom, lock the door and watch Internet pornography. Where were Katherine’s parents? They were at work. But it wouldn’t have mattered. When they were around, we just turned off the sound, or read erotic literature on a website called Kristen Archives. This is how we gained the indispensable knowledge that some women like to be ravished by farmhands, and others, by farm animals. The year was 1999. We had not yet sat through our first sex-ed class, but when we did, almost two years later, it was spectacularly disappointing. We had seen it all, and now we were shading in a diagram of the vas deferens.

Since our special after-school tradition came to an end over a decade ago, Friendster, Myspace, Facebook, Flickr, Formspring, Instagram and Twitter have emerged. But against all logic, nothing has changed in the sex-ed business. Our century is literally on the cusp of puberty, and yet despite these enormous social and technological changes, we remain largely incapable of giving kids the resources they need to deal with their own puberty. I’m talking here, specifically, about the province of Ontario. As you read this, kids from Sarnia to Kingston — kids who, on average, have viewed Internet porn by age 11 — are probably shading in the exact same vas deferens diagram I did. There’s nothing wrong with the vas deferens — or so I’m told — but surely there is more to sexual education in the 21st century than anatomy and colouring. Ontario currently boasts the most out-of-date sex-ed curriculum in Canada. It was last revised in 1998, which means sex ed was out of date when I took it.

[. . .]

Kids shouldn’t watch porn, but they do. We can’t un-invent the Internet. And we can’t reverse puberty. Case in point: In 2001, one of the most determined voyeurs in our special after-school group skipped sex ed at the request of her religious father — for whom an hour of vas deferens shading was just too much to bear. He told her to go to the library instead, which was fine with her. Who, after all, could resist an afternoon with the Kristen Archives?

June 12, 2013

Changing the FDA to meet the new needs of personalized medicine

Filed under: Health, Science — Tags: , , , , — Nicholas @ 08:31

At Marginal Revolution, Alex Tabarrok links to a new paper by Peter Huber:

In a brilliant new paper (pdf) (html) Peter Huber draws upon molecular biology, network analysis and Bayesian statistics to make some very important recommendations about FDA policy.

[. . .]

The current regime was built during a time of pervasive ignorance when the best we could do was throw a drug and a placebo against a randomized population and then count noses. Randomized controlled trials are critical, of course, but in a world of limited resources they fail when confronted by the curse of dimensionality. Patients are heterogeneous and so are diseases. Each patient is a unique, dynamic system and at the molecular level diseases are heterogeneous even when symptoms are not. In just the last few years we have expanded breast cancer into first four and now ten different types of cancer and the subdivision is likely to continue as knowledge expands. Match heterogeneous patients against heterogeneous diseases and the result is a high dimension system that cannot be well navigated with expensive, randomized controlled trials. As a result, the FDA ends up throwing out many drugs that could do good:

    Given what we now know about the biochemical complexity and diversity of the environments in which drugs operate, the unresolved question at the end of many failed clinical trials is whether it was the drug that failed or the FDA-approved script. It’s all too easy for a bad script to make a good drug look awful. The disease, as clinically defined, is, in fact, a cluster of many distinct diseases: a coalition of nine biochemical minorities, each with a slightly different form of the disease, vetoes the drug that would help the tenth. Or a biochemical majority vetoes the drug that would help a minority. Or the good drug or cocktail fails because the disease’s biochemistry changes quickly but at different rates in different patients, and to remain effective, treatments have to be changed in tandem; but the clinical trial is set to continue for some fixed period that doesn’t align with the dynamics of the disease in enough patients

    Or side effects in a biochemical minority veto a drug or cocktail that works well for the majority. Some cocktail cures that we need may well be composed of drugs that can’t deliver any useful clinical effects until combined in complex ways. Getting that kind of medicine through today’s FDA would be, for all practical purposes, impossible.

The alternative to the FDA process is large collections of data on patient biomarkers, diseases and symptoms all evaluated on the fly by Bayesian engines that improve over time as more data is gathered. The problem is that the FDA is still locked in an old mindset when it refuses to permit any drugs that are not “safe and effective” despite the fact that these terms can only be defined for a large population by doing violence to heterogeneity. Safe and effective, moreover, makes sense only when physicians are assumed to be following simple, A to B, drug to disease, prescribing rules and not when they are targeting treatments based on deep, contextual knowledge that is continually evolving

June 11, 2013

As if a pregnant woman doesn’t have enough things to worry about…

Filed under: Health, Media — Tags: , , — Nicholas @ 00:01

…there’s an entire industry devoted to the cause of warning pregnant women about possible, potential, unknown dangers all around them:

The only other real option is to take the position held by Joan Wolf, author of the excellent study about contemporary risk thinking, Is Breast Best? Taking on the Breastfeeding Experts and the New High Stakes of Motherhood. Wolf has explored how, in the US, pregnant women are frequently told: everything is potentially risky; you have control over fetal development, but we do not know how; actions that you think are innocuous are probably harmful, but we cannot tell you which ones; things you do or do not do might be more problematic at certain times in pregnancy, but we do not know when; what you do or do not do can produce disastrous or moderately negative effects, but we cannot predict either one.

Wolf’s assessment is that the only rational response is not a call for more information of this kind; rather, it is to recognise that there is far too much of it already. While science can tell us important things, what we need to come to terms with is the inevitability of risk, the fact that people do risky things all day long (in that there are outcomes of actions over which we do not have total control), but this is just life. It is not a problem, and we do not need to be ‘informed’ or ‘empowered’ about it.

The other sort of argument made by the critics of the RCOG report was that instead of ‘raising awareness’ of the theoretical risks of everyday chemicals, more advice and information should be given to pregnant women about ‘real harm’. Hence, instead of just focusing on making it clear to the RCOG what they should do with their report, the critics have engaged in a sort of ‘my risk is bigger than your risk’ competition. In the discussion so far, the risks we apparently really understand and should be even more informed about have included all the old chestnuts: coffee, alcohol, cigarettes and stress.

Indeed, an interesting ‘my risk is bigger than your risk’ theme is developing when it comes to ‘stress’. Here, the entirely legitimate point that it is not reasonable to worry people and cause anxiety for no reason has morphed into a claim about the apparently overwhelming evidence that ‘stress’ endangers the developing fetus. In reality, as the US sociologist Betsy Armstrong has explained, the ‘science’ supporting the idea that stress in pregnancy is a problem is far more contentious than such objections assume. The wider public discourse about this issue demands robust criticism not endorsement because of its scaremongering qualities. In any case, given that a pregnant woman can no more avoid ‘stress’ in her life than a she can a pre-prepared ham sandwich, it is worth asking quite where this line of argument takes us.

June 5, 2013

Do you suffer from “social jetlag”?

Filed under: Health, Science — Tags: , — Nicholas @ 10:27

And here’s more from Brainpickings:

“Six hours’ sleep for a man, seven for a woman, and eight for a fool,” Napoleon famously prescribed. (He would have scoffed at Einstein, then, who was known to require ten hours of sleep for optimal performance.) This perceived superiority of those who can get by on less sleep isn’t just something Napoleon shared with dictators like Hitler and Stalin, it’s an enduring attitude woven into our social norms and expectations, from proverbs about early birds to the basic scheduling structure of education and the workplace. But in Internal Time: Chronotypes, Social Jet Lag, and Why You’re So Tired, a fine addition to these 7 essential books on time, German chronobiologist Till Roenneberg demonstrates through a wealth of research that our sleep patterns have little to do with laziness and other such scorned character flaws, and everything to do with biology.

In fact, each of us possesses a different chronotype — an internal timing type best defined by your midpoint of sleep, or midsleep, which you can calculate by dividing your average sleep duration by two and adding the resulting number to your average bedtime on free days, meaning days when your sleep and waking times are not dictated by the demands of your work or school schedule. For instance, if you go to bed at 11 P.M. and wake up at 7 A.M., add four hours to 11pm and you get 3 A.M. as your midsleep.

Roenneberg traces the evolutionary roots of different sleep cycles and argues that while earlier chronotypes might have had a social advantage in agrarian and industrial societies, today’s world of time-shift work and constant connectivity has invalidated such advantages but left behind the social stigma around later chronotypes.

H/T to Lois McMaster Bujold for the link.

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