Quotulatiousness

December 31, 2015

Blogging will continue to be light

Filed under: Administrivia, Health, Personal — Tags: — Nicholas @ 18:37

I’m sharing this post from my iPhone while reclining in my bed in the Intensive Care Unit at Lakeridge Health in Oshawa. I’ve suffered a totally unexpected health setback on Tuesday evening and I don’t know when I’ll be able to resume blogging. There are still several postings in the queue, but once they’re posted, the blog may go quiet for some time. 

My best wishes to all of you in 2016. I hope to be back to a relatively normal life as soon as medicine and rest will allow. 

QotD: Some women really do dig jerks

Filed under: Health, Media, Quotations — Tags: , , , — Nicholas @ 01:00

Many of the “battered women” we are encouraged to sympathize with have a remarkable tendency to suffer from abuse at the hands of every man with whom they become involved. Tammy Wynette, the Country singer who gained fame with the song “Stand By Your Man,” was married to five men and left four of them (managing to die with her fifth marriage still intact). Most of her husbands are said to have abused her in some way, and teary-eyed retellings of her “tragic” life have been offered to the public.

I remind the reader of the central principle of male-female relations: women choose. They represent the supply; men represent the demand. If Tammy Wynette never took up with a man who failed to abuse her, there can be only one explanation: Tammy had a thing for nasty boys.

If you put a woman like this in a room with a dozen men, within five minutes she would be exclusively focused on the meanest, most domineering and brutal fellow in the room. Some women who had alcoholic fathers have a similar uncanny ability to detect the alcoholic in a room full of men, even if he is sober at the moment. “Women’s intuition” is a reality: it is an ability to pick up on tiny signals, slight nuances of facial expression that would go unnoticed by a man.

We are attracted to qualities in the opposite sex which our own sex lacks. For many women, this means an attraction to male brutality. Such women may claim to want a sensitive fellow who is in touch with his feelings, but this bears no relation to their behavior. What women say about men comes from their cerebral cortex; how they choose men depends upon their evolutionary more primitive limbic system. Even campus feminists choose arrogant jocks to “hook up” with, not male feminists in touch with their emotions. I have heard it suggested that the best reason not to strike a woman today is that you will never be able to get rid of her afterwards.

F. Roger Devlin, “The Question of Female Masochism”, Counter-Currents Publishing, 2014-09-17.

December 30, 2015

QotD: Medicine before antibiotics

Filed under: Health, History, Quotations, Science — Tags: — Nicholas @ 01:00

Explanation was the real business of medicine. What the ill patient and his family wanted most was to know the name of the illness, and then, if possible, what had caused it, and finally, most important of all, how it was likely to turn out

[…]

During the third and fourth years of [medical] school it gradually dawned on us that we didn’t know much that was really useful, that we could do nothing to change the course of the great majority of the diseases we were so busy analyzing, that medicine, for all its façade as a learned profession, was in real life a profoundly ignorant occupation

[…]

Once you were admitted [to hospital] … it became a matter of waiting for the illness to finish itself one way or the other … Medicine made little or no difference.

Lewis Thomas, The Youngest Science, 1983, quoted by John Derbyshire in “The Scariest Science”, Taki’s Magazine, 2014-11-13.

December 29, 2015

QotD: The health benefits of moderate drinking

Filed under: Cancon, Health, Law, Quotations, Wine — Tags: , , — Nicholas @ 01:00

Should we consider mandatory graphic warning labels on bottles of booze? Our science reporter Tom Blackwell reviewed various Canadian discussions of the idea in these pages yesterday, suggesting that it is being looked at behind the scenes by addiction researchers. Labels with colour images of diseased esophagi on liquor labels would, of course, mimic the approach Canada has already taken toward cigarettes. So, well, why not? They say if you have a hammer, everything looks like a nail: by a similar token, if your field is addiction, no doubt everything that has addictive qualities looks like an unsolved problem.

But there is one very obvious way in which liquor is not like cigarettes: scientists are reasonably sure that light drinking has positive public-health consequences. If you don’t believe me, you can look up articles like the one I have in front of me here from a 2013 issue of Annals of Oncology: its title is “Light Drinking Has Positive Public Health Consequences.” As a layman I obviously can’t be certain I have summarized this editorial correctly, but you’ll have to trust me.

Colby Cosh, “The real problem with liquor warning labels — there’s such a thing as good drinking”, National Post, 2015-12-17.

December 26, 2015

Moderate drinking and statistical health outcomes

Filed under: Health, Wine — Tags: , , — Nicholas @ 02:00

Aaron Carroll debunks some myths about booze and health:

Over the past year, I’ve tried to clear up a lot of the misconceptions on food and drink: about salt, artificial sweeteners, among others, even water.

Now let me take on alcohol: wine, beer and cocktails. Although I have written about the dangerous effects of alcohol abuse and misuse, that doesn’t mean it’s always bad. A part of many complex and delicious adult beverages, alcohol is linked to a number of health benefits in medical studies.

That doesn’t mean the studies provide only good news, either, or that the evidence in its favor is a slam dunk. You won’t be surprised to hear that, once again, my watchword — moderation — applies.

Research into how alcohol consumption affects health has been going on for a long time. A 1990 prospective cohort study included results of more than 275,000 men followed since 1959. Compared with those who never drank alcohol, those who consumed one to two drinks a day had a significantly reduced mortality rate from both coronary heart disease and “all causes.” Those who consumed three or more drinks a day still had a lower risk of death from coronary heart disease, but had a higher mortality rate over all.

A 2004 study came to similar conclusions. It followed about 6,600 men and 8,000 women for five years and found that compared with those who drank about one drink a day on average, those who didn’t drink at all and those who drank more than two drinks a day had higher rates of death. Results like these have been consistent across a number of studies in different populations. Even studies published in the journal Alcoholism: Clinical and Experimental Research agree that moderate drinking seems to be associated with a decreased risk of death over all.

However, alcohol seems to have different effects on different diseases. Almost all of the major benefits of drinking are seen in cardiovascular illnesses. In fact, with men, even consumption of a surprisingly large amount can seem protective.

December 16, 2015

To lower healthcare costs, increase the competition

Filed under: Business, Economics, Health, USA — Tags: , , — Nicholas @ 04:00

At Mother Jones, Kevin Drum links to an article that explicitly shows the cost of having monopoly providers in healthcare:

Regular readers of this blog should know that when it comes to the price of hospital care, it’s competition that matters, not insurance companies. In areas with only a single hospital, insurance companies have no leverage and have to accept whatever price the hospital charges. If there are lots of hospitals, they have to compete with each other to earn the insurance company’s business.

But in case you’re still skeptical, a team of researchers has analyzed a huge database of health care claims in the US to check this out. They found enormous regional variation in hospital costs for the same procedure, and one of the biggest drivers of this variation was competition:

Market power and hospital price

    Hospital market structure stands out as one of the most important factors associated with higher prices, even after controlling for costs and clinical quality. We find that hospitals located in monopoly markets have prices that are about 15.3 percent higher than hospitals located in markets with four or more providers. This result is robust across multiple measures of market structure and is consistent in states where the HCCI data contributors (and/or Blue Cross Blue Shield insurers) have high and low coverage rates.

Chipotle gains “green cred PR opportunities” and worse health outcomes for customers

Filed under: Business, Food, Health, Science, USA — Tags: , , , , — Nicholas @ 03:00

Henry Miller on the Faustian bargain Chipotle willingly made and is now paying for:

Chipotle, the once-popular Mexican restaurant chain, is experiencing a well-deserved downward spiral.

The company found it could pass off a fast-food menu stacked with high-calorie, sodium-rich options as higher quality and more nutritious because the meals were made with locally grown, genetic engineering-free ingredients. And to set the tone for the kind of New Age-y image the company wanted, Chipotle adopted slogans like, “We source from farms rather than factories” and, “With every burrito we roll or bowl we fill, we’re working to cultivate a better world.”

The rest of the company wasn’t as swift as the marketing department, however. Last week, about 140 people, all but a handful Boston College students, were recovering from a nasty bout of norovirus-caused gastroenteritis, a foodborne illness apparently contracted while eating Chipotle’s “responsibly raised” meats and largely organic produce.

And they’re not alone. The Centers for Disease Control and Prevention has been tracking another, unrelated Chipotle food poisoning outbreak in California, Illinois, Maryland, Minnesota, New York, Ohio, Oregon, Pennsylvania and Washington, in which victims have been as young as one year and as old as 94. Using whole genome sequencing, CDC investigators identified the DNA fingerprint of the bacterial culprit in that outbreak as E. coli strain STEC O26, which was found in all of the sickened customers tested.

Outbreaks of food poisoning have become something of a Chipotle trademark; the recent ones are the fourth and fifth this year, one of which was not disclosed to the public. A particularly worrisome aspect of the company’s serial deficiencies is that there have been at least three unrelated pathogens in the outbreaks – Salmonella and E. coli bacteria and norovirus. In other words, there has been more than a single glitch; suppliers and employees have found a variety of ways to contaminate what Chipotle cavalierly sells (at premium prices) to its customers.

QotD: The truth about beauty

Filed under: Health, Media, Quotations — Tags: , , — Nicholas @ 01:00

There are certain practical realities of existence that most of us accept. If you want to catch a bear, you don’t load the trap with a copy of Catch-22 — not unless you rub it with a considerable quantity of raw hamburger. If you want to snag a fish, you can’t just slap the water with your hand and yell, “Jump on my hook, already!” Yet, if you’re a woman who wants to land a man, there’s this notion that you should be able to go around looking like Ernest Borgnine: If you’re “beautiful on the inside,” that’s all that should count. Right. And I should have a flying car and a mansion in Bel Air with servants and a moat.

Welcome to Uglytopia — the world reimagined as a place where it’s the content of a woman’s character, not her pushup bra, that puts her on the cover of Maxim. It just doesn’t seem fair to us that some people come into life with certain advantages — whether it’s a movie star chin or a multimillion-dollar shipbuilding inheritance. Maybe we need affirmative action for ugly people; make George Clooney rotate in some homely women between all his gorgeous girlfriends. While we wish things were different, we’d best accept the ugly reality: No man will turn his head to ogle a woman because she looks like the type to buy a turkey sandwich for a homeless man or read to the blind.

There is a vast body of evidence indicating that men and women are biologically and psychologically different, and that what heterosexual men and women want in partners directly corresponds to these differences. The features men evolved to go for in women — youth, clear skin, a symmetrical face and body, feminine facial features, an hourglass figure — are those indicating that a woman would be a healthy, fertile candidate to pass on a man’s genes.

These preferences span borders, cultures, and generations, meaning yes, there really are universal standards of beauty. And while Western women do struggle to be slim, the truth is, women in all cultures eat (or don’t) to appeal to “the male gaze.” The body size that’s idealized in a particular culture appears to correspond to the availability of food. In cultures like ours, where you can’t go five miles without passing a 7-Eleven and food is sold by the pallet-load at warehouse grocery stores, thin women are in. In cultures where food is scarce (like in Sahara-adjacent hoods), blubber is beautiful, and women appeal to men by stuffing themselves until they’re slim like Jabba the Hut.

Amy Alkon, “The Truth About Beauty”, Psychology Today, 2010-11-01.

December 15, 2015

Hillary Clinton’s well-intentioned plans will make the prescription medicine market even worse

Filed under: Business, Economics, Government, Health, USA — Tags: , , , , — Nicholas @ 04:00

Another older post from Megan McArdle on the nice-soundbites-but-terrible-economic-notions from the Hillary Clinton campaign to fix the prescription medicine marketplace:

Hillary Clinton thinks drug development should be riskier, and less profitable. Also, your health insurance premiums should be higher. And there should be fewer drugs available.

This is not, of course, how the Clinton campaign would put it. The official line is that Americans are just paying too darn much for drugs, and she has a plan to stop that:

  • Regulate direct-to-consumer advertising more heavily, and strip its tax deductibility
  • Require drug companies to spend a certain percentage of revenue on research and development, or face penalty payments and the loss of their R&D tax credit (I am inferring that this is what she is talking about, since the actual language of the proposal is long on paeans to the importance of federal research funding and short on details)
  • Cap out-of-pocket costs for drugs
  • Reduce the exclusivity period for biologic drugs
  • Prohibit companies from making side payments to generic manufacturers to keep generic competition off the market
  • Allow drug reimportation
  • Require that new treatments be proved to be a substantial improvement over existing treatments — i.e., eliminate the dreaded “me too” drugs
  • Allow Medicare to “negotiate” drug prices

Eliminating the side payments seems eminently sensible. (Yes, yes, you can strip my libertarian card, but market-rigging contracts shouldn’t be enforced.) It also seems reasonable to require some sort of comparative effectiveness research. Other provisions will certainly drive down drug prices, at the risk of also driving down innovation.

Still other provisions, however, are simply bad economics. In what other market do we worry about having a second product available that’s merely just as good as the first? Should we really only have one antidepressant, one statin, one blood pressure medication, and so forth? Might there be variation among patients so that drugs that are statistically about equally effective in large groups are nonetheless individually more or less effective for different people? Might one drug’s side effects be better tolerated by some patients than another’s? Might having two drugs in the category help keep prices down?

Then there is notion that we should force pharmaceutical companies to spend a set percentage of their revenues on R&D. This seems to me to be … what’s the word I am looking for? Ah, I’ve got it: “insane.”

[…]

Economically, large parts of this plan make little sense. Politically, many of these items would be very difficult to pass, not least because the Congressional Budget Office would assess the likely effects and would make it sound much less appealing than it does in a gauzy stump speech. But away from those harsh realities, purely as campaign rhetoric, it probably works very well.

Asthma and the “Hygiene Hypothesis”

Filed under: Cancon, Health, Science — Tags: , , , — Nicholas @ 02:00

An older report at the BBC News website discusses recent research into childhood asthma:

Being exposed to “good bacteria” early in life could prevent asthma developing, say Canadian scientists.

The team, reporting in Science Translational Medicine, were analysing the billions of bugs that naturally call the human body home.

Their analysis of 319 children showed they were at higher risk of asthma if four types of bacteria were missing.

Experts said the “right bugs at the right time” could be the best way of preventing allergies and asthma.

In the body, bacteria, fungi and viruses outnumber human cells 10 to one, and this “microbiome” is thought to have a huge impact on health.

The team, at the University of British Columbia and the Children’s Hospital in Vancouver, compared the microbiome at three months and at one year with asthma risk at the age of three.

Children lacking four types of bacteria – Faecalibacterium, Lachnospira, Veillonella, and Rothia (Flvr) – at three months were at high risk of developing asthma at the age of three, based on wheeze and skin allergy tests.

The same effect was not noticed in the microbiome of one-year-olds, suggesting that the first few months of life are crucial.

Further experiments showed that giving the bacterial cocktail to previously germ-free mice reduced inflammation in the airways of their pups.

One of the researchers, Dr Stuart Turvey, said: “Our longer-term vision would be that children in early life could be supplemented with Flvr to look to prevent the ultimate development of asthma

“I want to emphasise that we are not ready for that yet, we know very little about these bacteria, [but] our ultimate vision of the future would be to prevent this disease.”

December 9, 2015

QotD: Masochism and the modern woman

Filed under: Health, Quotations — Tags: , — Nicholas @ 01:00

“If He Doesn’t Hit You, He Doesn’t Love You.” So runs an African proverb. Or a Russian proverb, according to other sources. Or a Bolivian proverb, according to still others. Perhaps it is all three. A similar Latin American saying, “The more you hit me, the more I love you,” turns up over 100,000 hits on Google.

It is hardly a new idea that female sexuality has a masochistic component. Indeed, this seems to be part of the folk wisdom of the world; in other words, it corresponds the observations of many persons of both sexes across many generations. Yet it is not easy to find extended discussion of it. Within the past century, most writing on the subject has been beholden to the Freudian tradition, a circumstance that does not inspire confidence. A more hopeful sign may be the sizable feminist literature aimed at refuting “the myth of female masochism.” If nothing else, such literature is testimony to the enduring reality of the corresponding folk belief; no one writes polemics against things that have absolutely no basis in reality.

It is not hard to understand why persons of both sexes are reluctant to talk about female masochism. No one wants to appear to be condoning the abuse of women. A prime component of masculinity is the instinct to protect women. In the European tradition, this has given rise to the principle that “a gentlemen never strikes a lady.” Pushing gallantry to the point of silliness, as usual, Thomas Fleming writes in Chronicles that “there is something unmanly about beating women, unmanly and sickening.”

But what if there is something in at least some women that responds positively to male violence?

F. Roger Devlin, “The Question of Female Masochism”, Counter-Currents Publishing, 2014-09-17.

December 8, 2015

Still more to learn about the human immune system

Filed under: Health, Science — Tags: , , — Nicholas @ 03:00

A brief post at Real Clear Science on a recent discovery in human immunology:

Think again if you thought that doctors had long since identified and described exactly how the body defends itself against microorganisms.

Scientists have recently discovered a whole new side to the immune system: a rapid immune response that kicks in well before any of the other known mechanisms.

“I hate to use the term ‘text books will write about this’, but this [discovery] really is brand new and we will need to write a new chapter,” says co-author Søren R. Paludan, professor of virology and immunology form the Department of Biomedicine, Aarhus University, Denmark.

In collaboration with groups from the US and Germany, the scientists showed that when the body’s outer defence, the mucosa lining that surrounds certain organs, is disturbed by a virus, the underlying layer of cells are the first to react and sound the alarm. They summon the body’s cell soldiers, which attack the invading virus.

Both this alarm system and the ‘soldier’ cells operate completely separately from what were believed to be the first responders to immune system attacks.

December 3, 2015

Medical charities and their prime mission

Filed under: Bureaucracy, Health — Tags: , , — Nicholas @ 05:00

David Warren is rather a skeptic on the long-term usefulness of big medical charities (and not just because, like any big bureaucracy, sooner or later the primary goal becomes for the organization itself to survive and grow rather than pursuing whatever they were originally created to do):

Medical “research” does similar direct damage. Huge foundations are created to “fight” every imaginable human ailment, and find new ones on which to build fresh fundraising efforts, should any of the old ones go stale. Grand sums are expended on “public awareness” campaigns, to encourage hypochondria and psychosomatic disorders. (I suspect, for instance, that the chief cause of lung cancer today is grisly health warnings on packets of cigarettes.) Money is raised in billions to “find a cure” for whatever. (Snake oil sales were on a much smaller scale.)

At the most elementary level, people should try to understand cause and effect. Vast numbers come to rely upon the metastasis of these soi-disant “charitable” bureaucracies. And if a cure is ever found, they will all be out of their overpaid jobs. Moreover, it is almost invariably some isolated, eccentric, unqualified and unfunded tyro, who makes the fatal discovery. That is why one of the principal tasks of any large medical foundation is to locate these brilliant “inventor” types, and sue them into surrender.

Does gentle reader know that almost all the increase in human longevity, over the last century or so, can be attributed to people washing their hands and taking showers? And most of the rest to better sewage disposal? Or that it took until almost the middle of the last century for life expectancy in the West to rise to levels last seen in the parish records of the Middle Ages? Which was when “modern” hygienic practices were last observed. (Large, centralized hospitals are the most efficient spreaders of infection today.)

Painkillers are nice, and I’m inclined to keep them, only if we realize that the blessing is mixed. They turn our minds away from futurity; they displace faith in God, to faith in doctors. They create the mindset that embraces “euthanasia.”

Of course, the main focus of contemporary liberal “philanthropy” is not on saving lives at all; rather on killing off babies — in Africa, by first choice. It is what the proggies used to call “population control,” until they invented better euphemisms. That is what truly gladdens the peons in the foundations of all the Bills and Melindas; and lights the corridors of the United Nations. That and the (still historically recent) “climate change” agenda.

December 2, 2015

Maximizing Profit under Monopoly

Filed under: Economics, Health — Tags: , , , , , — Nicholas @ 05:00

Published on 18 Mar 2015

AIDS has killed more than 36 million people worldwide. There are drugs available to treat AIDS, but the price of one pill is incredibly high in the U.S. — coming in at 25 times higher than its cost. Why is that? In this video, we show how patent rights have created a monopoly in the U.S. market for AIDS medication, causing pills to be very expensive. In other countries, however, such as India, which does not recognize patents on AIDS medication, prices remain low. Using this example, we go over how monopolies use market power to increase prices.

November 25, 2015

Food labelling laws and craft brewing … not a match made in heaven

Filed under: Bureaucracy, Business, Health, USA — Tags: , — Nicholas @ 03:00

Eric Boehm on how well-intentioned laws can still have significant and unforeseen negative side-effects:

Brewers are facing the prospect of spending potentially thousands to determine calorie counts for every variety of beer produced. Unless they spend the money to provide the information, breweries may never get their products into chain restaurants, like Buffalo Wild Wings and Applebee’s.

As is often the case with regulations, smaller breweries stand to lose the most.

“A regional craft brewer or a major brewery can spread the cost over a much larger volume of sales and it’s not so unreasonable for them,” said Paul Gatza, a former brewer who now heads the Boulder, Colorado, based Brewers’ Association, an industry group.

“Smaller guys that are just trying to sell a keg or two here or there, they have a decision to make on whether it is worth the additional cost to try to get their beers into chain restaurants,” Gatza told Watchdog.

The Food and Drug Administration is in the process of finalizing menu labeling rules that were part of the Affordable Care Act. Intended to make Americans more aware of their dietary choices, the rules are subject to controversy on several fronts, and the FDA announced in September that implementation of the new rules would be pushed back one full year, until December 2016, as the feds try to work out the kinks.

My favourite local brewery isn’t even a micro-brewery (they’re somewhere between a pico- and a nano-brewery): every week when I drop in, there are three or four new batches ready to sample (and it’s rare that there’s anything left of last week’s offerings). If they had to spend hundreds or even thousands of dollars to comply with detailed labelling requirements for every small batch they brewed, they’d never stand a chance of making a profit. I understand the urge to ensure that people have a chance to avoid ingredients that might make them ill, but this is the sort of regulation that tilts very heavily toward the big companies that have regional or national markets. A thousand dollars per product isn’t even a drop in the bucket to them, while to a small local business, that might be more than their profit margin when you require it be done for everything they produce.

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