Quotulatiousness

October 6, 2017

Are Branded Drugs Better? – Earth Lab

Filed under: Business, Health, Science — Tags: , , , — Nicholas @ 02:00

BBC Earth Lab
Published on 22 Jun 2017

When you’ve got a cold and need some medicine, do you ever wonder if there’s a difference between branded and non-branded drugs? Greg Foot explains the world of pharmaceuticals, backed up with some stonking examples and unexpected findings!

October 5, 2017

QotD: Legalizing drugs

Filed under: Law, Liberty, Quotations — Tags: , , , — Nicholas @ 01:00

It is not the business of the State to tell adults what to do with themselves, or how they interact with other consenting adults. Where drugs are concerned, any disadvantages in leaving people alone are greatly outweighed by the costs of the War on Drugs, which has reduced large parts of the world to violent chaos, and corrupted every law enforcement agency involved in fighting it, and been made an excuse for the destruction of due process rights in England and America.

Sean Gabb, quoted in “Wayne John Sturgeon talks to Sean Gabb of the Libertarian Alliance”, Sean Gabb, 2013-08-26.

August 17, 2017

Safe injection sites go rogue … to save lives

Filed under: Cancon, Health, Law — Tags: , , , , — Nicholas @ 03:00

In the National Post, Chris Selley wonders why the federal government has been so slow to come around to accepting the overall harm reduction offered by legal safe injection sites:

I suspect this generation of policymakers, and the previous one especially, will struggle to explain to their grandchildren just what on earth they thought they were doing about opioid addiction. I don’t mean the likes of Donald Trump, who seems to think a get-tough policing approach — a “war on drugs,” perhaps — might get the job done. I mean smart, reasonably compassionate Canadians, by no means all conservatives, whose worries about safe injection sites in particular look bizarre even today, when people are still using them.

“It’ll attract rubadubs” — as if Vancouver’s Downtown Eastside was a middle-class utopia before Insite set up shop. “There’ll be needles in the streets” — more than if the safe injection site weren’t there, you mean? And, of course: “Addicts should go to treatment instead” — as if people haven’t been trying and failing to get and stay clean this whole time; as if the alternative, on a day to day basis, might be not waking up the next morning to go get treatment.

To its credit, the Liberal government in Ottawa has loosened the regulatory reins. There are nine approved “supervised consumption sites” up and running across the country: five on the Lower Mainland, one in Kamloops, and three in Montreal. Six more, in Victoria, Ottawa, Toronto and Montreal, are approved and awaiting inspections. An additional 10 are in the approval process; four in Edmonton applied more than three months ago; one in Ottawa has been in the works, officially, since February.

This looks like progress, and to a great extent it is. But on Sunday, a group of activists in Toronto implicitly asked another trenchant question: why does it take so bloody long to set up a supervised injection site? Why are we waiting? It’s just clean needles, chairs and tables, overdose treatment medication, a nurse and a phone.

July 29, 2017

Things to keep firmly in mind before investing in legalized marijuana markets

Filed under: Business, Economics, USA — Tags: , , — Nicholas @ 04:00

There will definitely be money to be made as more and more jurisdictions move to legalize marijuana, but it’s not going to be like soup raining down from heaven — it’s not going to be a simple as just grabbing a bucket:

Here are Coyote’s first three rules of business strategy:

  1. If people are entering the business for personal, passionate, non-monetary reasons then the business is likely going to suck. When I say “suck”, I mean there may be revenues and customers and even some profits, but that the returns on investment are going to be bad**. Typically, the supply of products and services and the competitive intensity in an industry will equilibrate over time — if profits are bad, some competitors exit and the supply glut eases. But if people really love the industry and do not want to work anywhere else and get emotional benefits from working there, there always tends to be an oversupply problem. For decades, maybe its whole history, the airline industry was like this. The restaurant industry is this way as well. The brew pub industry is really, really like this — go to any city and check the list of small businesses for sale, and an absurd number will be brew pubs.
  2. If the business is frequently featured in the media as the up and coming place to be and the hot place to work, stay away. Having the media advertising for new entrants is only going to increase the competitive intensity and exacerbate the oversupply problem that every fast-growing industry inevitably faces as it matures.
  3. Beware the lottery effect — One or two people who made fortunes in the business mask the thousands who lost money (Freakonomics had an article on the drug trade positing that it works just this way — while assumes the illegal drug trade makes everyone in it rich, in fact only a few really do so and the vast majority are and always will be grinders making little money for high risk). Even those people who made tons of money in hot businesses sometimes just had good timing to get out at the right time before the reckoning came. Mark Cuban is famous as an internet billionaire, but in fact Broadcast.com, which he sold for over $5 billion to Yahoo, only had revenues in its last independent quarter of about $14 million and was losing money (that’s barely four times larger than my small company).

When I was at Harvard Business School, the first two cases in the first week of strategy class were a really cool high-tech semiconductor fab and a company that makes brass water meters that are sold to utilities. After we had read the cases but before we discussed them, the professor asked us which company we would like to work for. Everyone wanted the tech firm. But as we worked through the cases, it became clear that the semiconductor firm had an almost impossible profitability problem, while Rockwell water meters minted money. I never forgot that lesson — seemingly boring industries could be quite attractive, and this lesson was later hammered home for me as I later was VP of corporate strategy for Emerson Electric, a company that was built around making money from boring but profitable industrial products businesses.

[…]

** You can tell I have classical training in business strategy because my goal is return on investment. One can argue, perhaps snarkily but also somewhat accurately, that there is a new school of thought that does not care about profitability, revenues, or return on investment but on getting larger and larger valuations from private investors based on either user counts or just general buzz. I am entirely unschooled in this modern form of strategy. However, the general strategy of getting someone to overpay for something from you is as old as time. I mentioned Mark Cuban but there are many other examples. Donald Trump seems to have made a lot of money from a related strategy of fleecing his debt holders.

July 28, 2017

13 Reasons Jeff Sessions is a @$#/!

Filed under: Liberty, Politics, USA — Tags: , , , , — Nicholas @ 04:00

Published on Jul 27, 2017

Jeff Sessions is on the ropes with Donald Trump. Good.

The president is pissed because Sessions recused himself from the investigation of Russian attempts to influence the 2016 election. But here are a baker’s dozen of reasons to hate the attorney general, including his obsession with restarting the war on pot, his call to jack up mandatory minimums, and his support for civil asset forfeiture. Then there’s his lack of interest in due process, willingness to subvert state’s rights when they conflict with his desired outcome, and desire to lengthen prison terms for non-violent criminals. Also, he might be some kind of statist elf.
—–
During Sessions’ confirmation hearings, Democrats claimed the former Alabama senator was unfit for office because he was a racist, charges that were never really substantiated. But Sessions’ voting record and policy agenda are more than enough to disqualify him from being the nation’s top law enforcement officer.

Mostly Weekly is hosted by Andrew Heaton and written by Sarah Rose Siskind.

Edited by Austin Bragg and Sarah Rose Siskind.

Produced by Meredith and Austin Bragg.

Theme Song: Frozen by Surfer Blood.

July 18, 2017

QotD: Where progressives and libertarians agree

Actually, there are four other big areas where the two ideologies converge.

1. Immigration. Immigration restrictions deprive billions of basic liberties, impoverish the world, and do so on the backs of the global poor, most of whom are non-white.

2. Occupational licensing. Licensing laws bar tens of millions of people from switching to more lucrative and socially valuable occupations, all to benefit richer insiders at the expense of poorer outsiders.

3. War, especially the War on Terror. Since 2002, the U.S. has literally spent trillions fighting the quantitatively tiny problem of terrorism by waging non-stop wars in the Middle East. We don’t know what the Middle East would have looked like if the U.S. had stayed out, but it’s hard to believe it would be worse. And there’s no end in sight.

4. The criminal justice system, especially the War on Drugs. Hundreds of thousands of non-violent people, disproportionately poor and non-white, are in prison. Why? To stop willing consumers from doing what they want with their own bodies.

These four issues are so massive, you’d expect a staunch progressive/libertarian alliance would have been forged long ago. But of course it hasn’t. Why not? Some progressives flatly disagree with one or more of these policies; see Bernie contra open borders. But the bigger stumbling block is that progressives place far lower priority on these issues than libertarians. That includes war, unless the Republicans hold the White House.

Why not? I regretfully invoke my Simplistic Theory of Left and Right. The heart of the left isn’t helping the poor, or reducing inequality, or even minority rights. The heart of the left is being anti-market. With some honorable exceptions, very few leftists are capable of being excited about deregulation of any kind. And even the leftists who do get excited about well-targeted deregulation get far more excited about stamping out the hydra-headed evils of market.

Bryan Caplan, “Progressive/Libertarian: The Alliance That Isn’t”, Library of Economics and Liberty, 2017-06-22.

June 29, 2017

Words & Numbers – Just Say No to the War on Drugs

Published on 28 Jun 2017

Ted Cruz recently asserted that the United States military needs to be sent to Mexico to attack the drug cartels head-on.

This is a bad idea. But so is the drug war itself, both constitutionally and logically.

Forty-six years and one trillion dollars after its start, President Richard Nixon’s War on Drugs is still going, with 300,000 people currently in jail on drug charges. Meanwhile, 26 times as many people suffer from alcoholism as do heroin abuse, and eight times as many die from alcohol abuse as do heroin.

Many who support the war do so with the best of intentions, but has it really helped? Or has it done more harm than good, like the Prohibition of the 1920s? Is this war even legal in the first place?

James Harrigan and Antony Davies discuss these questions in this week’s Words and Numbers. Watch the conversation below or on our YouTube channel, or listen to it on SoundCloud.

June 17, 2017

What Happens When You Take Steroids? – Earth Lab

Filed under: Health, Science — Tags: , — Nicholas @ 02:00

Published on 8 Jun 2017

Have you ever wondered what happens to a human body when it takes anabolic steroids? Well, Greg Foot is here to explain all the science you need to know about steroids and why people use them for muscle growth.

May 13, 2017

Psychedelic Drugs: The Future of Mental Health

Filed under: Health, Law, Science, USA — Tags: , , , — Nicholas @ 04:00

Published on 12 May 2017

LSD, mushrooms, and ecstasy are finally getting attention from serious medical researchers. And their findings are astounding.
—-
A recent study found that MDMA-assisted therapy could help veterans suffering from PTSD. Another paper from Johns Hopkins presented evidence that therapy in conjunction with psilocybin mushrooms can help ease the mental suffering of terminal cancer patients.

These findings, among others, were presented at the 2017 Psychedelic Science Conference in Oakland, California, where researchers gather every few years to discuss the potential medical applications of psychedelics, including LSD, psilocybin mushrooms, and MDMA. The field has exploded thanks to reforms at the Food and Drug Administration that allow researchers, for the first time in decades, to study the effects of these drugs.

The organizer of the conference was the Multidisciplinary Association for Psychedelic Studies (MAPS), which is also funding much of this breakthrough research.

“It’s a fundamental right to explore one’s own consciousness,” says MAPS founder Rick Doblin. “We have the freedom of the press, the freedom of assembly, and the freedom of religion, and all those are based on the freedom of thought.”

At this year’s conference, Reason talked to researchers about the past, present, and future of this controversial and promising area of medical research.

Produced by Zach Weissmueller. Shot by Alex Manning and Weissmueller. Music by Kai Engel, Selva de Mar, and Lee Rosevere.

March 24, 2017

QotD: Academia resembles a drug gang

Filed under: Humour, Quotations, USA — Tags: , , — Nicholas @ 01:00

… both academia and drug gangs are marked by an endless supply of foot soldiers willing to work in terrible conditions for a small chance at living the good life. In drug gangs, the average street-corner dealer makes $3-something an hour; given that he’s got a high chance of being arrested or shot, why doesn’t he switch to McDonalds instead where the pay’s twice as good and the environment’s a lot safer? The article suggests one reason is because drug gangs offer the chance of eventually becoming a drug kingpin who is drowning in money.

(I’d worry they’re exaggerating the importance of this factor compared to wanting to maintain street cred and McDonalds jobs being much more regimented both in the application process and performance, but they’re the ones who have talked to anthropologists embedded in drug gangs, not me.)

Academia has the same structure. TAs and grad students work in unpleasant conditions for much less than they could make in industry, because there’s always the chance they could become a tenured professor who gets to live the life of the mind and travel to conferences in far-off countries and get summer vacations off.

The article describes this structure as “dualization” – a field that separates neatly into a binary classification of winners and losers.

Scott Alexander, “Non-Dual Awareness”, Slate Star Codex, 2015-07-28.

January 28, 2017

The “fantasy of addiction”

Filed under: Books, Health, Science — Tags: , , — Nicholas @ 02:00

Peter Hitchens explains how he started an argument that “will probably still be going on when I die”.

I never meant to start an argument about addiction. I had carried my private doubts on the subject around in my head for years, in the “heresy” section where I keep my really risky thoughts. And I don’t recommend disagreeing in public with Hollywood royalty, either, which is how it happened. In such a clash, most people will think you are wrong and Hollywood is right, especially if your opponent is Chandler Bing, the beloved character from Friends. Of course, he wasn’t really Chandler Bing, just an actor called Matthew Perry — but an actor with an entourage so big it filled an entire elevator at the BBC’s new studios in central London where we quarreled.

Our debate wasn’t even supposed to be about addiction. I’d been asked onto the corporation’s grand but faded late-night current affairs show Newsnight to talk about drug courts, one of many stupid ideas suggested by the idea of addiction. I reckoned my main opponent would be the other guest, Baroness (Molly) Meacher, whose name sounds like something out of The Beggar’s Opera. While she looks like the sort of harmless, kindly housewife who knits next to you on the bus, she is in fact a campaigner for the wilder sorts of drug liberalization. If this Chandler Perry wanted to horn in, well and good. Who cared? Yet when I began to sense sarcasm mingled with unearned superiority oozing from the character from Friends, I decided to let my impatience show.

Hence my rash, irreversible plunge into an argument which has been going on ever since, consuming billions of electrons on social media, and which will probably still be going on when I die. I heard myself using the words “the fantasy of addiction.” There. I’d done it. Let the heavens fall.

Chandler Bing called me various names and was even more sarcastic than before. He is extremely good at sarcasm, even if he understands very little about the drug problem. I have never heard the words “your book” pronounced with such eloquent contempt. The final “k” seemed to contain two whole syllables. Is this a Canadian thing? He was referring to my modest volume on the topic The War We Never Fought, so energetically ignored by reviewers and booksellers that it is known among London publishers as The Book They Never Bought.

January 23, 2017

Five easy fixes to improve US federal health policies

Filed under: Bureaucracy, Government, Health, USA — Tags: , , — Nicholas @ 03:00

Scott Alexander finds, to his surprise, that two of the candidates for the post of FDA commissioner in the Trump administration are following his blog or social media profile. To mark that, he offers five easy-to-implement policy fixes that would make a difference:

1. Medical reciprocity with Europe and other First World countries […] Right now, Europe has a licensing agency about as strict as the FDA approving medications invented in Europe. Any pharma company that wants their medication approved in both the US and Europe has to spend a billion or so dollars getting it approved by the FDA, and then another billion or so dollars getting it approved by the Europeans. A lot of pharma companies don’t want to bother, with the end result that Europe has many good medications that America doesn’t, and vice versa. Just in my own field, amisulpride, one of the antipsychotics with the best safety/efficacy balance, has been used successfully in Europe for twenty years and is totally unavailable here despite a real need for better antipsychotic drugs. If the FDA agreed to approve any medication already approved by Europe (or to give it a very expedited review process), we could get an immediate windfall of dozens of drugs with unimpeachable records for almost no cost. Instead, in the real world, we’re cracking down on imported Canadian pharmaceuticals because the Canadians don’t have exactly our same FDA which means that for all we know they might be adding thalidomide to every pill or something. This is exactly the sort of silly anti-competitive cronyist practice that a principled intelligent libertarian could do away with.

2. Burdensome approval process for generic medications […] How come Martin Shkreli can hike the dose of an off-patent toxoplasma drug 5000%, and everyone just has to take it lying down even though the drug itself is so easy to produce that high school chemistry classes make it just to show they can? The reason is that every new company that makes a drug, even a widely-used generic drug that’s already been proven safe, has to go through a separate approval process that costs millions of dollars and takes two to three years – and which other companies in the market constantly try to sabotage through legal action. Shkreli can get away with his price hike because he knows that by the time the FDA gives anyone permission to compete with him, he’ll have made his fortune and moved on to his next nefarious scheme. If the FDA allowed reputable pharmaceutical companies in good standing to produce whatever generic drugs they wanted, the same as every other company is allowed to make whatever products they want, scandals like Daraprim and EpiPens would be a thing of the past, and the price of many medications could decrease by an order of magnitude. […]

3. Stop having that thing allowing companies to “steal” popular and effective drugs that have been in the public domain for years, claim them as their private property, shut down all competitors, and jack up the price 10x just by bringing them up to date with modern FDA bureaucracy.

4. Stop having that thing where drug companies can legally bribe other companies not to compete with them. I like this one because it sounds anti-libertarian (we’re imposing a new regulation on what companies can do!) but I think it’s exactly the sort of thing that the crony capitalists would never touch but which principled intelligent libertarians like O’Neill and Srinivasan might be open to, in order to bring more actors into the marketplace.

5. Stop thwarting consumer diagnostic products and genetic tests […] Srinivasan comes from the genetic testing world himself, so he’s likely to be extra sympathetic to this.

January 7, 2017

QotD: LSD and the Baby Boomers

Filed under: History, Politics, Quotations, USA — Tags: , , , — Nicholas @ 01:00

My classmates [destroyed themselves on drugs]. The authentic imaginations, the really innovative people of my generation, the most daring of my generation took the drug. Now I, for some reason, felt that the LSD was untested, and I did not want to experiment with it. But I was very interested in it. I was interested in all types of vision quests at the time. I went up with fellow students [from SUNY-Binghamton] to see Timothy Leary speak at Cornell. I saw him, and it made me uneasy that here was the guru with such a crowd around him, but his face was already twitching. I could see that this was not going to end well, and it did not.

So when I got to graduate school in 1968, I can attest to the fact that no authentically radical student of the 1960s ever went to graduate school. So all that were left were the time-servers, who parasitically [lived] on the achievements of the 1960s, for heaven’s sake. Any authentic leftist who had a job at a university in the 1970s or ’80s or ’90s should have been opposing the entire evolution of the university — that is, toward this administrative bureaucracy that has totally robbed power from the faculty. The total speciousness and fraud of academic leftism is proven by the passivity of these people in every department of the university to that power play that happened.

Camille Paglia, “Everything’s Awesome and Camille Paglia Is Unhappy!”, Reason, 2015-05-30.

September 3, 2016

QotD: Hunter S. Thompson’s ideal breakfast

Filed under: Humour, Quotations — Tags: , , , — Nicholas @ 01:00

Breakfast is the only meal of the day that I tend to view with the same kind of traditionalized reverence that most people associate with Lunch and Dinner.

I like to eat breakfast alone, and almost never before noon; anybody with a terminally jangled lifestyle needs at least one psychic anchor every 24 hours, and mine is breakfast. In Hong Kong, Dallas or at home – and regardless of whether or not I have been to bed – breakfast is a personal ritual that can only be properly observed alone, and in a spirit of genuine excess. The food factor should always be massive: four Bloody Marys, two grapefruits, a pot of coffee, Rangoon crepes, a half-pound of either sausage, bacon or corned beef hash with diced chilies, a Spanish omelette or eggs Benedict, a quart of milk, a chopped lemon for random seasoning, and something like a slice of key lime pie, two margaritas and six lines of the best cocaine for dessert……. Right, and there should also be two or three newspapers, all mail and messages, a telephone, a notebook for planning the next 24 hours, and at least one source of good music….… All of which should be dealt with outside, in the warmth of a hot sun, and preferably stone naked.

Hunter S. Thompson, “Fear and Loathing on the Campaign Trail ’76: Third-rate romance, low-rent rendezvous — hanging with Ted Kennedy, Jimmy Carter, and a bottle of Wild Turkey”, Rolling Stone, 1976-06-03.

July 30, 2016

First Opium War – Lies – Extra History

Filed under: Britain, China, History — Tags: , , — Nicholas @ 03:00

Published on 23 Jul 2016

Order the limited edition Opium Wars wall scroll before it leaves forever on July 27! http://bit.ly/2a138ur
James talks about our mistakes, and adds additional stories, for Federico da Montefeltro and the First Opium War!
____________

Quick story about Federico da Montefeltro: after losing an eye in a jousting accident, he ordered his doctor to cut a divot out of his nose so that his remaining eye had a better view and he could still fight in battles.

Now on to the Opium War! The Macartney expedition did not draw on the knowledge of Jesuit missionaries or even merchants who were familiar with Chinese court customs, because the British felt that a noble like Macartney was the only fitting representative. He didn’t come prepared to handle the kowtow, and he didn’t understand that the Chinese would have been more interested in British agricultural tech than they were in trinkets. James reads the disdainful letter which the Daoguang Emperor wrote to King George III in response to the embassy. There also happened to be a political upheaval in the Chinese palace at the time, so if the British had arrived sooner, they may have met with a different result and avoided the Opium Wars entirely. Once the war came to a head, it caused great division in Britain. Even though it was a war to sell illegal drugs, it was often recast as a war the Chinese provoked by insisting on the kowtow and treating other nations as vassals. Two traders by the names of James Matheson and William Jardine helped tip the scales for war because it helped their business, which had gotten a huge start in the opium trade. The Jardine-Matheson trading firm still exists today, and is a multibillion dollar company. Back in China, the British blockade of Canton’s port led to an odd first confrontation. A British ship called the Royal Saxon ran the blockade, so the British fired a warning shot to make it turn back. The Chinese, to prove they still controlled their sovereign waters, took this as an opportunity to challenge the blockade. Thus, their defense of a British smuggler led them into a war that, ironically, was about stopping British smugglers. The British official directing the war efforts, Charles Elliot, found himself in an awkward situation. He loved his country, but he morally objected to the British agenda in China. He tried to pave a moderate path, only to be fired and reviled as a failure. But after he left, the war truly got vicious. The British committed many atrocities in their campaign. They never sought to hold China, however, because their wars in India had taught them how impossible such an undertaking would be. Thus they settled on the unequal treaty. And as for Walpole… well, he started it, of course. Tea became such a large part of Britain’s economy because of the large tax levied on it. And who levied that tax? It was Walpole. He actually repealed an earlier, heavily resented tax and got political accolades for doing so, then introduced a much higher tax under a different name that flew under the radar even while it brought in hundreds of thousands of pounds for the government every year. The government’s reliance on tea for funding would later propel them to take such extraordinary measures to secure access to tea via Chinese trade. So who really started the Opium War? Well. It was Walpole.

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