Quotulatiousness

May 15, 2013

Canadians’ hypocrisy on climate change

Filed under: Cancon, Environment, Politics — Tags: , , , — Nicholas @ 00:01

Stephen Gordon fired off a tweetstorm yesterday:

May 13, 2013

Space Oddity … performed in space

Filed under: Cancon, Media, Space — Tags: , , — Nicholas @ 07:59

International Space Station Commander, Chris Hadfield, performs a revised version of David Bowie’s Space Oddity. Seen in this video is the Larrivée Parlor guitar that has found it’s home on the ISS for the last decade. Chris has used this Parlor, the first guitar in space, to write and record the first musical recordings in space. Here at Larrivée we refer to Chris as “The Space Cowboy”.

Below is the original description as posted by Chris himself on his YouTube channel… enjoy.

Published on May 12, 2013

A revised version of David Bowie’s Space Oddity, recorded by Commander Chris Hadfield on board the International Space Station.

With thanks to Emm Gryner, Joe Corcoran, Andrew Tidby and Evan Hadfield for all their hard work.

Update:

May 12, 2013

Influenza: the trade-off between virulence and contagion

Filed under: Health, Media, Science — Tags: , , , , , — Nicholas @ 10:34

Matt Ridley explains why the breathless claims that this or that flu outbreak could rival the Spanish Flu pandemic of 1918-19 should not be taken too seriously:

Here we go again. A new bird-flu virus in China, the H7N9 strain, is spreading alarm. It has infected about 130 people and killed more than 30. Every time this happens, some journalists compete to foment fear, ably assisted by cautious but worried scientists, and then tell the world to keep calm. We need a new way to talk about the risk of a flu pandemic, because the overwhelming probability is that this virus will kill people, yes, but not in vast numbers.

In recent years flu has always proved vastly less perilous than feared. In 1976 more people may have died from bad reactions to swine-flu vaccine than from swine flu. Since 2005, H5N1 bird flu has killed 374 people, not the two million to 7.4 million deemed possible by the World Health Organization. In 2009, H1N1 Mexican swine flu proved to be a normal flu episode despite apocalyptic forecasts.

No doubt some readers will remind me that, in the story of the boy who cried “Wolf!”, there eventually was a wolf. And that in 1918 maybe 50 million people died of influenza world-wide. So we should always worry a bit. But perhaps it’s not just luck that has made every flu pandemic since then mild; it may be evolutionary logic.

Of course, just about every story about influenza you’ll encounter goes the Chicken Little route:

There’s no mystery as to why we talk up the risk every time: All the incentives point that way. Who among the headline-seeking journalists, reader-seeking editors, fund-seeking scientists, contract-seeking vaccine makers or rear-end-covering politicians has even a modest incentive to say: “It may not be as bad as all that”?

Thomas Szasz was no conservative

Filed under: Health, Liberty, Media — Tags: , , , , — Nicholas @ 09:50

In Reason, Jacob Sullum looks at an essay on the late Thomas Szasz that puzzlingly attempts to portray him as a staunch conservative:

In an interesting but puzzling Aeon essay, Cornell historian Holly Case notes the resemblance between contemporary doubts about the scientific foundation of psychiatry and the critique first laid out by Thomas Szasz half a century ago. “It might be that the world has only recently come around to his way of thinking,” Case suggests. Yet she misconstrues an important aspect of Szasz’s thinking by portraying him as “a staunch Republican” and a “conservative,” apparently unaware of his self-proclaimed libertarianism. Szasz, who died last year at the age of 92, was a Reason contributing editor for decades. He described the main motivation for his intellectual career as “my passion against coercion,” which he opposed (outside of situations involving the defense of rights) no matter who was advocating it, left, right, or center. Hence he opposed forced psychiatric treatment, but he also opposed interference in consensual transactions between psychiatrists and voluntary patients. Here he parted company with some left-wing critics of psychiatry.

[. . .]

But Case focuses mainly on common ground between what she views as right-wing and left-wing critics of psychiatry. Beginning in the 1960s, she writes, “Right and left sought to eliminate insanity in order to lionise dissent, legitimise the marginal and condemn the new normal. Few other issues show a convergence of right and left so far-reaching, while still allowing both sides to adhere to their politics and maintain a sense of total opposition.” At the same time, she says “Szasz was conspicuously alone in mounting the barricades from the right,” so she really needs him to be a right-winger. Bending the facts to fit her thesis, she ascribes to Szasz a “distinctively conservative perspective.” That label does not jibe with his opposition to drug prohibition and his forthright defense of the right to suicide, two major themes of his career that Case tellingly ignores. Szasz’s position on physician-assisted suicide combined both of these themes and demonstrated that his perspective was in fact distinctively libertarian. He opposed Oregon’s Death With Dignity Act (later imitated by Washington) because it medicalized a moral decision and required people to meet government-dictated criteria before they could legally end their lives. If the drug laws did not make it difficult for people to obtain substances useful for suicide (such as barbiturates), he said, there would be no need for physician-assisted suicide.

British emergency wards are overcrowded … so we’ll fine the ambulance service!

Filed under: Britain, Bureaucracy, Health — Tags: , , — Nicholas @ 08:59

Hard to come up with an explanation for this perverse policy:

Ministers came under fresh criticism for their handling of the NHS last night after it emerged the ambulance service will be hit with £90 million in fines — as punishment for the chaos blighting casualty departments.

Critics said the fines will simply deprive trusts of vital funds that could help tackle the deterioration in patient services.

A new penalty clause that was written into ambulance trust contracts from last month will levy fines of £200 for every patient who has to wait for longer than 30 minutes for admission to A&E, and £1,000 for each patient forced to wait more than an hour.

You can understand the desire to speed the delivery of injured people to the emergency services they need, but how does it make any kind of sense to punish the ambulance service because the emergency wards they need to get their patients into are overcrowded? Unless the ambulance service has some kind of magic ability to shift priorities in the hospitals, fining them for patients’ wait times makes less than zero sense.

But acute overcrowding in A&E departments has led to increasing ambulance ‘jams’ formed as they queue to unload, with waits of four hours recorded at some hospitals at the busiest times.

Damning new figures reveal that during the past year there were more than 265,000 occasions in England when ambulance staff took more than half an hour to deliver patients into the hands of hospital doctors.

And shockingly, more than 37,000 patients had to wait over an hour to move on to the wards.

Official guidelines say ambulances should deliver patients, clean the ambulance and be back out on the road within 15 minutes. A longer wait is seen as ‘unsafe’.

Yet the chaos in A&E departments is so bad that at one, the Norfolk and Norwich University Hospital, doctors were forced to put up a tent to act as a makeshift ward to treat patients alongside the ambulance queue.

May 10, 2013

Colby Cosh on “gendercide”

Filed under: Cancon, Health, Law, Liberty, Religion — Tags: , , , , — Nicholas @ 10:53

Despite the federal government’s efforts to keep this debate from happening, we apparently are going to be having a big national debate about abortion. (For those following from outside the borders of Former Soviet Canuckistan, Canada doesn’t actually have any abortion law on the books at the moment, and Stephen Harper’s government of “bitter-clinging, right-wing, Bible-thumping, fundamentalist Christian” Conservatives is desperate not to have to bring one in.) Colby Cosh explains why the efforts by some back-bench MPs to use “gendercide” as a way to force the government’s hand won’t work:

Here, then, is my contribution to the big conversation.

(1) “Gendercide” is incoherent religious militancy in cheap drag. (Editors certainly shouldn’t be taking sides by putting it in headlines as if it were an actual thing.)

(2) However you feel about personal eugenics, which is an accurate name for “mothers choosing babies that are likely to be better in some respect they deem relevant”, the Era Of It is arriving now and will not be wished away.

(3) Sex-selective abortion perpetrated for reasons of religious superstition is, upon all evidence, a marginal phenomenon in this country, probably a fading one, and quite likely to be an inherently self-correcting one. It makes a shabby excuse for blowing up the political truce our country clings to when it comes to the topic of abortion. (It seems remotely possible that Stephen Harper has perceived this and concurs with it.)

(4) In particular, no statute is likely to be effective against sex selection by mothers. We had one, you know, and it actually made a hypothetical exception for parents at risk of X-linked gene disease. A Liberal government devoted to “reproductive choice” criminalized sex-selective embryo implantation by means of the Assisted Human Reproduction Act; a Supreme Court found that law offensive to the Constitution; and a Conservative government closed the agency that was supposed to enforce it because it had accomplished the sum total of jack squat ever.

(5) People who wish to police sex-selective abortion had better figure out what exactly kinds they don’t like. And why. And what other reasons for a woman to have an abortion don’t cut their brand of mustard. And whether they really want their wives, girlfriends, daughters or nieces to end up as a future Case 6 running afoul of the law.

(6) Fellow-travellers of Mark Warawa who think he makes an awesome test case for parliamentary purity should consider looking for one that, pardon the metaphor, doesn’t have quite so many oopsies in its DNA.

Early signs of “rejuvenation therapy”?

Filed under: Health, Science — Tags: , , — Nicholas @ 08:41

An interesting report from the Harvard Gazette on some research into a possibility of reducing some of the effects of aging, specifically aging of the heart:

Two Harvard Stem Cell Institute (HSCI) researchers — a stem cell biologist and a practicing cardiologist at Brigham and Women’s Hospital — have identified a protein in the blood of mice and humans that may prove to be the first effective treatment for the form of age-related heart failure that affects millions of Americans.

When the protein, called GDF-11, was injected into old mice, which develop thickened heart walls in a manner similar to aging humans, the hearts were reduced in size and thickness, resembling the healthy hearts of younger mice.

Even more important than the implications for the treatment of diastolic heart failure, the finding by Richard T. Lee, a Harvard Medical School professor at the hospital, and Amy Wagers, a professor in Harvard’s Department of Stem Cell and Regenerative Biology, ultimately may rewrite our understanding of aging.

Research of this type may be very important as the baby boomer generation enters retirement age … not necessarily to extend total lifespan, but to increase the chances for healthy activity longer into our existing lifespan. Few of us would want to live to 100 if the last 20 years are pain-wracked, immobile, and inactive … but being able to live that long and managing to keep doing the things we like to do for most of that time? That’d be much more appealing to many of us.

May 8, 2013

Nanotechnology comes to the aid of diabetics

Filed under: Health, Science — Tags: , , — Nicholas @ 12:25

Matt Peckham discusses a technology that may help diabetics avoid the majority of their frequent insulin injections:

Say you’re diabetic: Instead of having to inject yourself with insulin multiple times a day, imagine only having to do it once a week. Crazy, right? And instead of your syringe harboring glucose-regulating insulin, imagine it filled with nanoscopic particles you fire into your bloodstream — particles capable of detecting when your body’s blood sugar levels rise and releasing insulin accordingly.

Thanks to research conducted at North Carolina State University, the University of North Carolina at Chapel Hill, the Massachusetts Institute of Technology and Children’s Hospital Boston, what sounds like a Kurzweilian science fiction fantasy may soon be reality for the estimated 25.8 million children and adults in the U.S. alone — 8.3% of the population, according to the American Diabetes Association – with high blood sugar (and 366 million in all worldwide).

“We’ve created a ‘smart’ system that is injected into the body and responds to changes in blood sugar by releasing insulin, effectively controlling blood-sugar levels,” says NC State University biomedical engineering assistant professor Dr. Zhen Gu, the lead author of a paper describing the work (via NC State news). ”We’ve tested the technology in mice, and one injection was able to maintain blood sugar levels in the normal range for up to 10 days.”

May 6, 2013

Genetically modified barley may mean the end of skunky beer

Filed under: Australia, Science — Tags: , — Nicholas @ 08:54

The Register‘s Simon Sharwood on an Australian development that might herald new long-life beers:

Researchers at Australia’s University of Adelaide have unlocked the secret to letting beer age without it tasting like old socks.

Doctor Jason Eglington of the university’s School of Agriculture, Food and Wine explained that barley contains an enzyme called “lipoxygenase”. The enzymatic process produces several substances, among them an aroma volatile, catchily named “trans-2-nonenal”. The latter substance, over time, gives old beer a nasty taste and odour.

Eglington, who heads the university’s Barley Program*, learned that some ancient strains of barley have a defective version of lipoxygenase.

Some selective breeding later and the booze boffins have produced a new barley with everything a brewer could want — except working lipoxygenase.

May 5, 2013

A second life for the American chestnut tree?

Filed under: Environment, Science, USA — Tags: — Nicholas @ 10:25

The Economist reports on a trial of genetically modified chestnut trees:

Once upon a time, according to folklore, a squirrel could travel through America’s chestnut forests from Maine to Florida without ever touching the ground. The chestnut population of North America was reckoned then to have been about 4 billion trees. No longer. Axes and chainsaws must take a share of the blame. But the principal culprit is Cryphonectria parasitica, the fungus that causes chestnut blight. In the late 19th century, some infected saplings from Asia brought C. parasitica to North America. By 1950 the chestnut was little more than a memory in most parts of the continent.

American chestnuts may, however, be about to rise again — thanks to genetic engineering. This month three experimental patches will be planted, under the watchful eye of the Department of Agriculture, in Georgia, New York and Virginia. Along with their normal complements of genes, these trees have been fitted with a handful of others that researchers hope will protect them from the fungus.

The project has been organised by the Forest Health Initiative (FHI), a quango set up to look into the idea of using genetic engineering to rescue species of tree whose populations have been devastated by fungal diseases or insect pests. It has sponsored research at several universities, and this month’s trial is the first big field test. If it works, the FHI will ask the government for permission to plant transgenic chestnuts in the wild, with the intention of re-establishing the species in America’s woodlands. And if that goes well, it could provide a model for projects to re-establish elm trees (being devastated by Dutch elm disease, a beetle-born fungal infection), ash trees (threatened in North America by a beetle called the emerald ash borer, and in Europe by a fungal disease called ash dieback) and a fir tree known, confusingly, as the eastern hemlock (which is plagued by the woolly adelgid, a sap-sucking bug).

May 2, 2013

Cherrypicking the result you prefer from a recent Medicaid study

Filed under: Health, Media, USA — Tags: , , , — Nicholas @ 10:43

Megan McArdle explains why a recent study’s results may be much more important than you might gather from the way it’s been reported so far:

Bombshell news out of Oregon today: a large-scale randomized controlled trial (RCT) of what happens to people when they gain Medicaid eligibility shows no impact on objective measures of health. Utilization went up, out-of-pocket expenditure went down, and the freqency of depression diagnoses was lower. But on the three important health measures they checked that we can measure objectively — glycated hemoglobin, a measure of blood sugar levels; blood pressure; and cholesterol levels — there was no significant improvement.

I know: sounds boring. Glycated hemoglobin! I might as well be one of the adults on Charlie Brown going wawawawawawa . . . and you fell asleep, didn’t you?

But this is huge news if you care about health care policy — and given the huge national experiment we’re about to embark on, you’d better. Bear with me.

Some of the news reports I’ve seen so far are somewhat underselling just how major these results are.

“Study: Medicaid reduces financial hardship, doesn’t quickly improve physical health” says the Washington Post.

The Associated Press headline reads “Study: Depression rates for uninsured dropped with Medicaid coverage”

At the New York Times, it’s “Study Finds Expanded Medicaid Increases Health Care Use”

I think Slate is closer to the mark, though a bit, well, Slate-ish: “Bad News for Obamacare: A new study suggests universal health care makes people happier but not healthier.”

This study is a big, big deal. Let me explain why.

A layman’s guide to evaluating statistical claims

Filed under: Media, Politics, Science — Tags: , , — Nicholas @ 10:23

We’re awash with statistics, 43.2% of which seem to be made up on the spot (did you see what I did there?). Betsey Stevenson & Justin Wolfers offer some guidance on how non-statisticians should approach the numbers we’re presented with in the media:

So how can non-experts and policy makers separate the useful research from the dross? Allow us to offer six rules.

1. Focus on how robust a finding is, meaning that different ways of looking at the evidence point to the same conclusion. Do the same patterns repeat in many data sets, in different countries, industries or eras? Are the findings fragile, changing as one makes small changes in how phenomena are measured, and do the results depend on whether particularly influential observations are included? Thanks to Moore’s Law of increasing computing power, it has never been easier or cheaper to assess, test and retest an interesting finding. If the author hasn’t made a convincing case, then don’t be convinced.

2. Data mavens often make a big deal of their results being statistically significant, which is a statement that it’s unlikely their findings simply reflect chance. Don’t confuse this with something actually mattering. With huge data sets, almost everything is statistically significant. On the flip side, tests of statistical significance sometimes tell us that the evidence is weak, rather than that an effect is nonexistent. Remember, results can be useful even if they don’t meet significance tests. Sometimes questions are so important that we need to glean whatever meaning we can from available data. The best bad evidence is still more informative than no evidence.

3. Be wary of scholars using high-powered statistical techniques as a bludgeon to silence critics who are not specialists. If the author can’t explain what they’re doing in terms you can understand, then you shouldn’t be convinced. You wouldn’t be convinced by an analysis just because it was written in ancient Latin, so why be impressed by an abundance of Greek letters? Sophisticated statistical methods can be helpful, but they can also hide more than they reveal.

4. Don’t fall into the trap of thinking about an empirical finding as “right” or “wrong.” At best, data provide an imperfect guide. Evidence should always shift your thinking on an issue; the question is how far.

5. Don’t mistake correlation for causation. For instance, even after revisions and corrections, Reinhart and Rogoff have demonstrated that economic growth is typically slower when government debt is higher. But does high debt cause slow growth, or is slow growth in gross domestic product the cause of higher debt-to-GDP ratios? Or are there other important determinants, such as populist spending by a government looking to get re- elected, which is more likely when growth is slow and typically drives debt up?

6. Always ask “so what?” Are the factors that drove the observed negative correlation between debt and GDP likely to exist today, in the U.S.? Does it even make sense to speak of “the” relationship between debt and economic growth, when there are surely many such relationships: Governments borrowing simply to fund their re-election are likely harming growth, while those investing in much-needed public works can provide the foundation for growth. The “so what” question is about moving beyond the internal validity of a finding to asking about its external usefulness.

April 28, 2013

Reason.tv: Why the GOP Should Embrace Science

“What has always alleviated our scarcity? What has always alleviated our environmental problems? Technology. What breeds technological dynamism? Economic success,” explains Joshua Jacobs, co-founder of the Conservative Future Project, a new pro-science, pro-technology organization that’s trying to get the Republican Party to embrace an open-ended future filled with driverless cars, stem-cell research, and private space exploration.

If that sounds like a tall order for a party whose leading presidential candidates in 2012 waffled on whether they believed in evolution, you’re right. But Jacobs argues forcefully that the GOP is no less anti-science than the Democrats and actually has a long history of pushing scientific and technological innovation.

Nick Gillespie sat down with Jacobs in Reason‘s D.C. studio to talk about how conservatives might stop standing athwart history yelling stop and march boldly into the future.

April 25, 2013

What we “know” as opposed to what is actually true

Filed under: Business, Football, Health, Law — Tags: , , , , — Nicholas @ 13:36

We all know the NFL is in serious trouble as more evidence comes out about the relationship between playing professional football and brain damage in later life. But what we know may not be true:

Dr. Everett Lehman, part of a team of government scientists who studied mortality rates for NFL retirees at the behest of the players’ union, discovered that the pros live longer than their male counterparts outside of the NFL. The scientists looked at more than 3,000 pension-vested NFL retirees and expected 625 deaths. They found only 334. “There has been this perception over a number of years of people dying at 55 on the average,” Dr. Lehman told me. “It’s just based on a faulty understanding of statistics.”

The scientists also learned that, contrary to conventional wisdom, NFL players commit suicide at a dramatically lower rate than the general male population. The suicides of Junior Seau, Dave Duerson, and Andre Waters don’t represent a trend but outliers that attract massive attention, and thereby massively distort the public’s perception. More typical was the death of Pat Summerall, who passed away quietly last week at 82 after a productive post-career career.

Indeed, a 2009 study by University of Michigan researchers reported that NFL retirees are far more likely to own a home, possess a college degree, and enjoy health insurance than their peers who never played in the league. The myth of the broke and broken-down athlete is just that: a myth. A few surely struggle after competition ceases; most apply their competitive natures to new endeavors.

It’s true that skill-position players on rosters for five or more years in the NFL faced elevated levels of Alzheimer’s, Lou Gehrig’s, and Parkinson’s disease deaths. But some perspective is in order. Of the 3,439 retired athletes studied by Lehman’s group, less than a dozen succumbed to deaths directly attributable to these neurodegenerative killers. Had Parkinson’s killed one rather than the two retirees it did kill, for example, its rate would have been lower among players than among the general population.

It’s quite possible the NFL is concerned (and ensuring that it is seen to be concerned) primarily because of the need to address public perceptions, rather than as a defensive move against future or ongoing legal challenges.

April 24, 2013

QotD: Welcoming the DSM-V appropriately

Filed under: Books, Health, Humour, Quotations, Science — Tags: , , — Nicholas @ 00:01

The much-awaited arrival of DSM-5 (the fifth edition of the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders) should ensure that every human being is classed as insane. At this point we might be able to start again and consider what psychiatry is for. Genomics is keen to help in the effort by finding the loci that are associated with all sorts of mental disorders. Enter a huge population based study funded by the National Institute of Mental Health: “Our findings show that specific SNPs are associated with a range of psychiatric disorders of childhood onset or adult onset. In particular, variation in calcium-channel activity genes seems to have pleiotropic effects on psychopathology. These results provide evidence relevant to the goal of moving beyond descriptive syndromes in psychiatry, and towards a nosology informed by disease cause.” Hmm. I think that when authors have to use words like “pleiotropic” and “nosology” there is a high chance that they do not know what they are talking about. So before welcoming the marriage of genomics and psychiatry, let us remember that there is a strong history of madness on both sides.

Richard Lehman, “Richard Lehman’s journal review—22 April 2013”, BMJ Group blogs, 2013-04-22

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