A more useful lesson might be skepticism about personalized medicine. Personalized medicine – the idea that I can read your genome and your blood test results and whatever and tell you what antidepressant (or supplement, or form of therapy) is right for you has been a big idea over the past decade. And so far it’s mostly failed. A massively polycausal model would explain why. The average personalized medicine company gives you recommendations based on at most a few things – zinc levels, gut flora balance, etc. If there are dozens or hundreds of things, then you need the full massively polycausal model – which as mentioned before is computationally intractable at least without a lot more work.
(You can still have some personalized medicine. We don’t have to know the causes of depression to treat it. You might be depressed because your grandfather died, but Prozac can still make you feel better. So it’s possible that there’s a simple personalized monocausal way to check who eg responds better to Prozac vs. Lexapro, though the latest evidence isn’t really bullish about this. But this seems different from a true personalized medicine where we determine the root cause of your depression and fix it in a principled way.)
Even if we can’t get much out of this, I think it can be helpful just to ask which factors and sciences are oligocausal vs. massively polycausal. For example, what percent of variability in firm success are economists able to determine? Does most of the variability come from a few big things, like talented CEOs? Or does most of it come from a million tiny unmeasurable causes, like “how often does Lisa in Marketing get her reports in on time”?
Maybe this is really stupid – I’m neither a geneticist or a statistician – but I imagine an alien society where science is centered around polycausal scores. Instead of publishing a paper claiming that lead causes crime, they publish a paper giving the latest polycausal score for predicting crime, and demonstrating that they can make it much more accurate by including lead as a variable. I don’t think you can do this in real life – you would need bigger Big Data than anybody wants to deal with. But like falsifiability and compressability, I think it’s a useful thought experiment to keep in mind when imagining what science should be like.
Scott Alexander, “The Omnigenic Model As Metaphor For Life”, Slate Star Codex, 2018-09-13.
February 4, 2021
QotD: The (as-yet-unfulfilled) promise of “personalized medicine”
January 29, 2021
Ancient Aryans: The History of Crackpot N@zi Archaeology
Atun-Shei Films
Published 22 Nov 2019Thanks to Indiana Jones, everybody knows that German archaeologists in the 1930s were searching for occult ancient artifacts … but that’s just the tip of the iceberg. In this educational video, I explore how the N@zis turned the discipline of prehistoric archaeology into a cog in their propaganda machine, and how their crazy conspiracy theories about lost civilizations continue to haunt us to this day.
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January 27, 2021
QotD: Open-source the data
Eric S. Raymond, “Open-Sourcing the Global Warming Debate”, Armed and Dangerous, 2009-11-23.
January 24, 2021
The Great Wine Blight
The History Guy: History Deserves to Be Remembered
Published 9 Sep 2020In the 19th century, the Great Wine Blight threatened the very existence of grapes. But the pestilence brought into Europe by American vines was eradicated by the use of those very same vines. The History Guy recalls how American indigenous vines saved the wine industry, and how you can help to preserve its future.
This is original content based on research by The History Guy. Images in the Public Domain are carefully selected and provide illustration. As very few images of the actual event are available in the Public Domain, images of similar objects and events are used for illustration.
Special thanks to Stone Hill Winery, Hermann, Missouri:
https://stonehillwinery.comYou can purchase the bow tie worn in this episode at The Tie Bar:
All events are portrayed in historical context and for educational purposes. No images or content are primarily intended to shock and disgust. Those who do not learn from history are doomed to repeat it. Non censuram.
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Script by CDH
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January 23, 2021
QotD: “Genetics is interesting as an example of a science that overcame a diseased paradigm”
Genetics is interesting as an example of a science that overcame a diseased paradigm. For years, basically all candidate gene studies were fake. “How come we can’t find genes for anything?” was never as popular as “where’s my flying car?” as a symbol of how science never advances in the way we optimistically feel like it should. But it could have been.
And now it works. What lessons can we draw from this, for domains that still seem disappointing and intractable?
Turn-of-the-millennium behavioral genetics was intractable because it was more polycausal than anyone expected. Everything interesting was an excruciating interaction of a thousand different things. You had to know all those things to predict anything at all, so nobody predicted anything and all apparent predictions were fake.
Modern genetics is healthy and functional because it turns out that although genetics isn’t easy, it is simple. Yes, there are three billion base pairs in the human genome. But each of those base pairs is a nice, clean, discrete unit with one of four values. In a way, saying “everything has three billion possible causes” is a mercy; it’s placing an upper bound on how terrible genetics can be. The “secret” of genetics was that there was no “secret”. You just had to drop the optimistic assumption that there was any shortcut other than measuring all three billion different things, and get busy doing the measuring. The field was maximally perverse, but with enough advances in sequencing and computing, even the maximum possible level of perversity turned out to be within the limits of modern computing.
(This is an oversimplification: if it were really maximally perverse, chaos theory would be involved somehow. Maybe a better claim is that it hits the maximum perversity bound in one specific dimension)
Scott Alexander, “The Omnigenic Model As Metaphor For Life”, Slate Star Codex, 2018-09-13.
January 20, 2021
QotD: Helping the homeless
I see a number of sources nowadays trying to pin these closures entirely on tight-fisted Republican governors, and I am sure this is partly true. But this misses an important element — that civil libertarians had real issues with both the conduct of these institutions (e.g. One Flew Over The Cuckoo’s Nest) and the fairness of the forced-institutionalization process. Also tied up in all this were Cold War stories of Soviet Russia using institutionalization in mental hospitals as a way to dispose of dissidents. After all, it is a short step from the totalitarian view of ideology (ie that everyone must believe, not just comply) to declaring that any deviation from the official orthodoxy constitutes mental illness.
Warren Meyer, “Why I Go Back and Forth On Issues of Forced Psychiatric Institutionalization”, Coyote Blog, 2018-09-20.
January 17, 2021
Hector Drummond on Boris “Cane-Toad” Johnson
As a teaser to attract new subscribers to his Patron and SubscribeStar pages, Hector Drummond shared this piece on the ecological disaster of Australia’s 1930s cane-toad importation and the similar political disaster of Boris Johnson in Britain:
In the 1930s Queensland farmers were facing trouble with large numbers of cane beetles eating the sugar crops that were an important part of the state’s economy. So the Bureau of Sugar Experiment Stations came up with a cunning plan. They would import some cane toads (a native of middle and south America), because cane toads ate cane beetles. This was sure to solve the problem in a trice. One-hundred and two cane toads were duly imported into the state, from Hawaii as it happened, to do the job.
Unfortunately this soon became a classic case of the cure being worse than the disease. In fact it wasn’t any cure at all because the cane toads didn’t bother much with the cane beetles, and instead ate everything else they could wrap their tongues around. The other thing they did was multiply at an explosive rate. These days there are estimated to be 200 million cane toads in Australia, mainly in Queensland, and they cause havoc with the native fauna, not least because they have nasty poison-producing glands on the back of their head which the native animals have no naturally-evolved defence against. Curious pet dogs who mess about with a toad can die.
In 2019 Britain was facing its own crisis. It had become obvious to half the country that Theresa May’s Conservative government was deliberately trying to prevent Brexit from happening. As the other parties were even worse, the only hope for a real Brexit to take place was if a new pro-Brexit leadership in the Conservative party could be installed. After a titanic struggle, this finally happened, and Alexander “Boris” Johnson became the new leader, with Michael Gove and advisor Dominic Cummings at his side.
Unfortunately Johnson has proven to be Britain’s own version of the cane toad, a cure that is vastly worse than the disease. Johnson, at least, proved to be more able than his Australian counterpart at doing the job that was required of him. Whereas the Australian toad was about as interested in cane beetles as Olly Robbins was in getting the UK out of the EU, Johnson at least gave us a middling type of Brexit which, as fudged as it was, was at least far better than anything any of his fellow MPs could have got.
But in terms of being worse than the disease, Cane-Toad Johnson has proven to be far, far more destructive than the cane toad ever was. The cane toad, after all, is merely an ecological pest, whereas Johnson has proved to be a dangerous menace to the country’s liberty, prosperity and health. The poison from his glands has leached into our very life. We have become like domestic dogs who have been forced to lick them every day.
January 13, 2021
QotD: Bureaucracy as a filter
But imagine it takes the doctor an hour of painful phone calls to even get the right person from the insurance company on the line. Now there’s a cost involved. If your patient is going to die without the medication, you’ll probably groan and start making the phone calls. But if your patient doesn’t really need it, and you just wanted to approve it in order to be nice, now you might start having a heartfelt talk with your patient about the importance of trying less expensive medications before jumping right to the $10,000 one.
Organizations have a legal incentive not to deny people things, because the people involved can sue them. But they have an economic incentive not to say yes to every request they get. Seeing how much time and exasperation people are willing to put up with in order to get what they want is an elegant way of separating out the needy from the greedy if every other option is closed to you.
This story makes sense and would help explain why bureaucracy gets so bad, but I’m not sure it really fits the evidence. People complain a lot about bureaucracy in places like the Department of Motor Vehicles, but the DMV doesn’t lose anything by giving you a drivers license and isn’t interested in separating out people who really want licenses from people who only want them a little. If the DMV can be as bureaucratic as it is without any conspiratorial explanation, maybe everything is as bureaucratic as it is without any conspiratorial explanation.
Scott Alexander, “Bureaucracy as Active Ingredient”, Slate Star Codex, 2018-08-31.
January 12, 2021
QotD: The use and abuse of stigma
But stigma, and hence the fear of stigma, can be beneficial in a social creature such as Man. I want the good opinion of my neighbours, I do not want them to think I am rude or dishonest. Fearing the stigma of being thought so, I try harder to be polite and honest.
Of course, wanting the good opinion of others may, in certain situations, have bad effects. Wanting the good opinion of my superior in the Nazi Party would be very bad. But that does not mean that desiring the good opinion of others is always intrinsically bad. In the same way, fear of stigmatization is not always bad (and there can be no fear of stigma without the existence of the thing itself). For example, it might be that people are discouraged from taking drugs, drinking too much, or stealing for fear of being stigmatized.
Theodore Dalrymple, “Stigma and Sympathy”, The Iconoclast, 2020-09-23.
January 10, 2021
QotD: Sexual equality and the risk of demographic collapse
Eric S. Raymond, “Fearing what might be true”, Armed and Dangerous, 2009-10-23.
January 9, 2021
QotD: Heinlein’s “Future History”
Written between 1939 and 1950 for quickie publication in pulp magazines, the Future History is a series of snapshots of what is now an alternate human future — one that features atomic energy, solar system imperialism, and the first steps to deep space, all within a Spenglerian choreography of social progress and occasional resurgent barbarity. It stands with Isaac Asimov’s Foundation trilogy as a monument of golden-age science fiction.
In some respects the Future History has not aged any better than one might expect. Like other young nerds who created the science-fiction canon, Heinlein was interested in rocketry before it was thought to have any practical use. And Heinlein was really, really good at acquiring or faking expert knowledge of those topics in which he happened to get interested. The man knew his Tsiolkovsky.
The result, in the key story of the Future History, is an uncannily accurate description of the design and launch of a Saturn V rocket. (Written before 1950, remember.) But because Heinlein happened not to be interested in electronic computers, all the spacefaring in his books is done with the aid of slide rules or Marchant-style mechanical calculators (which, in non-Heinlein history, had to become obsolete before humans could go to Luna at all). Heinlein sends people to colonize the moon, but nobody there has internet, or is conscious of its absence.
Colby Cosh, “Heinlein’s monster? The literary key to Elon Musk’s sales technique”, National Post, 2018-02-12.
January 7, 2021
QotD: Sneering at “the throwaway society”
These are not new truths, even if it took the Covid-19 pandemic to reveal them again. The throwaway age began because of public-health campaigns a century ago to control the spread of pathogens. Disposable products were celebrated for decades for promoting hygiene and saving everyone time and money. It wasn’t until the 1970s that they became symbols of decadent excess, and then only because of economic and ecological fallacies repeated so often that they became conventional wisdom.
In a strange turn of events, the most affluent society in history suddenly turned into a mass of neurotic hoarders. Sifting through garbage for valuables, an activity formerly associated with the most destitute inhabitants of Third World shantytowns, became a moral duty in American suburbs. Greens campaigned for “zero waste” and a “circular economy” in which disposable products would be outlawed. They confidently predicted that the throwaway society was doomed, but if they’d known anything about its history, they would have realized that it was created for very good reasons — and that it will endure long after their lamentations are forgotten.
John Tierney, “Let’s Hold On to the Throwaway Society”, City Journal, 2020-09-13.
January 4, 2021
QotD: Repressing the facts in genetic research
In fact, given the state of our present knowledge, I judge all three of these outcomes are near certain. I have previously written about some of the evidence in Racism and Group Differences. The truth is out there; well known to psychometricians, population geneticists and anyone who cares to look, but surrounded by layers of denial. The cant has become thick enough to, for example, create an entire secondary mythology about IQ (e.g., that it’s a meaningless number or the tests for it are racially/culturally biased). It also damages our politics; many people, for example, avert their eyes from the danger posed by Islamism because they fear being tagged as racists. All this repression has been firmly held in place by the justified fear of truly hideous evils – from the color bar through compulsory sterilization of the “inferior” clear up to the smoking chimneys at Treblinka and Dachau. But … if the repressed is about to inevitably return on us, how do we cope?
It’s not going to be easy. I saw this coming in the mid-1990s, and I’m expecting the readjustment to be among the most traumatic issues in 21st-century politics. The problem with repression, on both individual and cultural levels, is that when it breaks down it tends to produce explosions of poorly-controlled emotional energy; the release products are frequently ugly. It takes little imagination to visualize a future 15 or 20 years hence in which the results of behavioral genetics are seized on as effective propaganda by neo-Nazis and other racist demagogues, with the authority of science being bent towards truly appalling consequences.
Eric S. Raymond, “A Specter is Haunting Genetics”, Armed and Dangerous, 2010-06-19.
January 2, 2021
Victor Davis Hanson’s 2020 review
I’m not normally prone to weak puns, but I think it’s not unfair to call 2020 an Anus horribilis rather than an Annus horribilis, because the last twelve months have been utter ass:
The year 2020 is now commonly dubbed the annus horribilis — “the horrible year.” The last 10 months certainly have been awful.
But then so was 1968, when both Martin Luther King Jr. and Bobby Kennedy were assassinated. The Tet Offensive escalated the Vietnam War and tore America apart. Race and anti-war riots rocked our major cities. Protesters fought with police at the Democratic National Convention in Chicago. A new influenza virus, H3N2 (the “Hong Kong flu”), killed some 100,000 Americans.
But an even worse 2020 saw the COVID-19 outbreak reach global pandemic proportions by March. Chinese officials mislead the world about the origins of the disease — without apologies.
Authorities here in the U.S. were sometimes contradictory in declaring quarantines either effective or superfluous. Masks were discouraged and then mandated. Researchers initially did not know how exactly the virus spread, only that it could be lethal to those over 65 or with comorbidities.
Initial forecasts of 1 million to 2 million Americans dying from the virus unduly panicked the population. But earlier assurances that the death toll wouldn’t reach 100,000 falsely reassured them.
[…]
For the first time in American history, given the lockdowns and the cold-weather viral resurgence, there was neither a traditional Thanksgiving nor Christmas for many people.
Yet amid the death, destruction and dissension, history will show that America did not fall apart.
In remarkable fashion, researchers created a viable and safe COVID-19 vaccine in less than a year — a feat earlier described as impossible by experts.
The nation went into recession but avoided the forecasted depression. This was partly because America in early 2020 was booming by historical standards, and partly because the Trump administration and Congress quickly infused some $4 trillion of liquidity into the inert economy.
For all the charges and counter-charges of voter fraud and Trump being a sore loser, President-elect Joe Biden will eventually take office. And Donald Trump will leave it.
This is the dawning of the Age of the Putz
At least, that’s how David Warren sees it:
“Covid 19 Masks” by baldeaglebluff is licensed under CC BY-SA 2.0
… the spirit of Resolution has been dying in our society, and that is among the principal reasons that our public life has been down-trending. It is what we may call the Age of the Putz, using the term with its full Yiddish vigour, yet in English where we may say it in the presence of women and children. Yes, it means stupid, foolish, worthless, idle and so forth. But as I understand, at the fulcrum, it means “easy to swing around.” It means being led by one’s rope, as it were. A putz (understandably confused with a schmuck, or a nebbish) does what he has been told by the authorities, and oddly like the brave, he does not hesitate. But this is because he can’t endure pain. He can be agreeable, yet without charm. (Reader warning: my Yiddish may be defective.)
This would be acceptable, in the sense that there is nothing we can do about a putz — he has already surrendered — but a line must be drawn somewhere, if only for our own edification. This is where, in current jargon, we cross over from a putz, to a Karen. In my apartment building alone, there must be a dozen who have made this “transition.”
They are the ones who think they will die, if you’ve forgotten your bat-muzzle, or threaten to step within seventy inches of them, in an elevator. They may appear to be making a threat, by the shrieks of complaint they utter, but really it is only fear. It is, to be plain, the opposite of Resolution. The authorities, taking them for putzes, have easily instilled the “public health” terror, with “science” they have made up, and may yank them here or there as they want.
Could I make videos, I would record a snide little number that composed itself in my head, last May (when we were only two months into “fifteen days to flatten the curve”). It was entitled, “You’re Going To Kill People!” The dance component was a variation on the hippie-days twist, in which Walmart shoppers try to stay two feet clear of each other, while looting modest consumer durables.
