Quotulatiousness

March 19, 2018

Prehistoric migrations

Filed under: Europe, History, Science — Tags: , , , — Nicholas @ 05:00

In a Science article from last year, Ann Gibbons discusses the ancient migrations that can now be traced using DNA analysis:

After World War II, many scholars recoiled from studying migrations, in reaction to the Nazi misuse of history and archaeology. The Nazis had invoked migrations of “foreign” groups to German territory to justify genocide. “The whole field of migration studies was ideologically tainted,” says archaeologist Kristian Kristiansen of the University of Gothenburg in Sweden. Some researchers also resisted the idea that migration helped spread key innovations such as farming, partly because that might imply that certain groups were superior.

Nor did researchers have a reliable method to trace prehistoric migrations. “Most of the archaeological evidence for movement is based on artifacts, but artifacts can be stolen or copied, so they are not a real good proxy for actual human movement,” says archaeologist Doug Price of the University of Wisconsin in Madison, who tracks ancient migration by analyzing isotopes. “When I started doing this in 1990, I thought people were very sedentary and didn’t move around much.”

Today, however, new methods yield more definitive evidence of migration, sparking an explosion of studies. The isotopes Price and others study are specific to local water and food and thus can reveal where people grew up and whether they later migrated. DNA from ancient skeletons and living people offers the “gold standard” in proving who was related to whom.

The new data confirm that humans have always had wanderlust, plus a yen to mix with all manner of strangers. After the first Homo sapiens arose in Africa, several bands walked out of the continent about 60,000 years ago and into the arms of Neandertals and other archaic humans. Today, almost all humans outside Africa carry traces of archaic DNA.

That was just one of many episodes of migration and mixing. The first Europeans came from Africa via the Middle East and settled there about 43,000 years ago. But some of those pioneers, such as a 40,000-year-old individual from Romania, have little connection to today’s Europeans, Reich says.

His team studied DNA from 51 Europeans and Asians who lived 7000 to 45,000 years ago. They found that most of the DNA in living Europeans originated in three major migrations, starting with hunter-gatherers who came from the Middle East as the glaciers retreated 19,000 to 14,000 years ago. In a second migration about 9000 years ago, farmers from northwestern Anatolia, in what is now Greece and Turkey, moved in.

That massive wave of farmers washed across the continent. Ancient DNA records their arrival in Germany, where they are linked with the Linear Pottery culture, 6900 to 7500 years ago. A 7000-year-old woman from Stuttgart, Germany, for example, has the farmers’ genetic signatures, setting her apart from eight hunter-gatherers who lived just 1000 years earlier in Luxembourg and Sweden. Among people living today, Sardinians retain the most DNA from those early farmers, whose genes suggest that they had brown eyes and dark hair.

H/T to PaleoAnthropology+ for the link.

QotD: Unintended consequences, recycling division

Filed under: Business, Economics, Environment, Quotations — Tags: , — Nicholas @ 01:00

The hallmark of science is a commitment to follow arguments to their logical conclusions; the hallmark of certain kinds of religion is a slick appeal to logic followed by a hasty retreat if it points in an unexpected direction. Environmentalists can quote reams [!] of statistics on the importance of trees and then jump to the conclusion that recycling paper is a good idea. But the opposite conclusion makes equal sense. I am sure that if we found a way to recycle beef, the population of cattle would go down, not up. If you want ranchers to keep a lot of cattle, you should eat a lot of beef. Recycling paper eliminates the incentive for paper companies to plant more trees and can cause forests to shrink.

Steven Landsburg, The Armchair Economist, 1993.

March 13, 2018

The economic argument for carbon taxes

Filed under: Economics, Environment, Government — Tags: , , , , — Nicholas @ 05:00

Tim Worstall explains what a carbon tax is supposed to do, as opposed to what many environmental activists want it to do:

The essential economic analysis is that carbon emissions are an “externality.” There are costs to third parties of the freely chosen activities of consenting adults. If there aren’t such third party costs then the adults get to consent – as long as your bedroom contains only those freely consenting adults then what goes on there is up to you. But if there are those third party costs – say, the noise from the enjoyments causes lost sleep among the neighbours – then some societal power to force an adjustment seems reasonable enough.

Again, economics analyses here by suggesting that we’ll get too much, or too many, of those third party costs if people aren’t paying for them. If we’ve not got to pay to soundproof the orgy then we’ll have more orgies than if we do. It’s fair that we insist upon such soundproofing perhaps. But sometimes we cannot insist upon such direct actions – then we’ve got to try and change the price system. Which is what the carbon tax does.

There are benefits to using fossil fuels – transport, heat, cooking and so on. Given current technological levels immediate banning would mean billions die – commonly thought to be a Bad Thing. But there are those costs imposed upon others as well in the climate change the emissions cause. The answer is that we look to that greatest good of the greatest number, the utilitarian answer. Where emissions produce more value than the damage they cause – including over time – then we want them to continue. Where they don’t then we want them to stop. That way we get the maximum possible value being created and thus all humans – over time – are as rich as we can be given current technologies.

Calculating what this number is, this tax rate, is also known as determining the social cost of carbon emissions. The Stern Review may or may not have exactly the right number but it’s a good enough starting point, $80 per tonne CO2. Say 50 cents or so per gallon of gas. Slap that tax on and we’ve corrected the price system. People who use gas are now paying the environmental costs of their use. So, anything they use it for must create greater value than the damage being caused. We’re copacetic at this point, we’ve the optimal level of emissions.

Note that this logic still works whatever you think of the rate. 1 cent or $100 a gallon, the logic is still the same, we’re only arguing over what is that social cost of carbon. Stick a tax on of whatever it is and we’re done.

Even if climate change isn’t a problem, or isn’t happening, we do still need some tax revenues somewhere. It’s also better to tax consumption than incomes or capital, better to tax things inelastic in demand with respect to price than those elastic. Fossil fuel consumption taxation is a consumption tax and the demand for fossil fuels is, in the short to medium term at least, inelastic. We’re fine with fuel taxation therefore.

For a quick backgrounder on the concept of externalities, MR University did a video on this a few years back. For reasons to worry that your government might not be quite as revenue-neutral in imposing a Pigouvian tax, Warren Meyer also has doubts.

March 10, 2018

Carl Jung, “the Madame Blavatsky of psychotherapy”

Filed under: Books, Health, History — Tags: , , , , , — Nicholas @ 03:00

A few notes on Carl Jung, by Anthony Daniels (more often known by his pen name, Theodore Dalrymple), commenting on a biography from several years ago:

What exactly were [Jung’s] achievements? Oddly enough, although this biography is more than 800 pages long (649 of them are text, each of them so closely printed that they are the equivalent of two normal pages), by the time you finish it you will nevertheless be hard put to say. You will know a lot about the petty quarrels and squabbles in which Jung repeatedly engaged, and about the details of his domestic life, but relatively little about why any of these things matter in the first place. The author therefore assumes not only a familiarity with Jung’s ideas, and a sympathy towards them, but that the reader also assumes that Jung is worthy of such a lengthy biography. This is not an assumption I share, and though the book is written in serviceable prose, it contains not a single humorous remark. From very early on, therefore, I picked it up with some words that Macaulay wrote in a review of a two-volume biography of Lord Burleigh echoing through my mind like the insistent snatch of a tune (I quote from memory): Compared with the labour of reading these volumes, all other labour, the labour of thieves on the treadmill, the labour of children in the mines, the labour of slaves on the plantation, is but a pleasant recreation. That Miss Bair has been diligent is indisputably true; that her diligence has been wisely applied, unfortunately, is a more open question.

Some men are born charlatans, some achieve charlatanry, and some have charlatanry thrust upon them. Jung was decidedly not born a charlatan — or at least, he was not one throughout the whole of his career. True, he grew up in a family with a more than average number of table-rappers, which no doubt inclined him later to the study of the esoteric (for it certainly never occurred to him to wonder why the esoteric was, in fact, esoteric), and was subjected in his youth to that Teutonic windiness which comes so easily, though no means inevitably, to those who think and write in the German language. There is nothing quite like esoteric windiness for creating a penumbra of profundity, to which bored society ladies are drawn like flies to dung: and this no doubt explains how he became the Madame Blavatsky of psychotherapy. At the same time, however, he received a thorough grounding in classics as well as in science, spoke four languages fluently, could read Latin as if it were his native tongue, was not bad at Greek, and contributed several expressions to our daily discourse — complex, collective unconscious, archetypes, animus and anima, persona, introvert and extrovert — which by itself is far more than most of us will ever achieve. This is not the same as saying, however, that he contributed to human knowledge: for it is perfectly possible to give names to non-existent entities.

[…]

One of his patients, who has gone down in history as the solar-phallus man, thought (among many other strange things) that there was a phallus that emerged from the sun, and that by causing this solar appendage to move, he controlled the weather, particularly the wind. Jung subsequently discovered, in his reading about ancient myths, that there was a Persian Mithraic belief of exactly the same kind as his patient’s. Now his patient was not a well-educated or widely read man, so it seemed to Jung impossible that he had learnt of the Mithraic myth from external sources. He therefore concluded that the form of myths was almost — as we should now put it — hard-wired into the human psyche, and he called these forms archetypes. The collective unconscious was full of such archetypes.

Jung was a preternaturally unclear writer and thinker: he would never say anything clearly when obfuscation would do. Whether this was from lack of talent or an unconscious appreciation that clarity led to the possibility of contradiction and even refutation, no one can say, but the precise nature of archetypes, their ontological status as it were, has remained unclear ever since. At any rate, the solar-phallus man’s delusion, which he quoted for the rest of his long life, was the rock on which his theory was built: a somewhat inadequate basis for an entire, far-reaching theory about the mental life of all of humanity. But Jung’s theorizing was always like an inverted pyramid: a mountain of speculation resting on a pin-prick of fact.

There were obvious problems with the theory of archetypes. The theory suggested itself to Jung because of the exact, or very close, correspondence between the madman’s delusion and the original Mithraic myth: but how close did correspondences have to be before they were manifestations of archetypes, which were more platonic forms than actual contents of the mind? Only an analyst can say, of course, and there is no public criterion other than the analyst’s authority.

QotD: The beginnings of archaeology

Filed under: History, Middle East, Quotations, Science — Tags: , , — Nicholas @ 01:00

It is now forty-five summers since, at age eighteen, I stood myself in the ruins of Ninevah — across the Tigris from Mosul in post-modern Iraq, the seat of Christian Assyria. Gentle reader may be aware that the Assyrians, Yazidis, Armenians, Turkmen, Shabaki, and for that matter, a portion of the Arabs who once lived around that town have been slaughtered or exiled over the last two years by the Daesh. The self-styled “Islamic Caliphate” has also made a show of demolishing Mosul’s remarkable Museum, and the more celebrated ancient monuments, starting with the purported tombs of Jonah and several other Old Testament prophets.

How one wishes that the French and British, rivals for archaeological glory from the early Victorian age, had succeeded in floating more of the treasures they had uncovered, on great rafts down the Mesopotamian rivers to Basrah and the sea — and then by ship to safe new homes in the Louvre and British Museum. That was the heroic age of “Orientalism,” when under the burning sun, and the noses of Ottoman administrators, and in the face of Arab raids and depredations — goaded by an excited popular interest in the recovery of deep Biblical history — the lost kingdoms and empires of the Near and Middle East were being rediscovered. Not only the tireless spadework, but the ingenious decoding of ancient tablets found in subterranean libraries of clay, extended our detailed knowledge of the human past by thousands of years.

This was a gentleman’s contest, and I am struck by the way, without rules or treaties, the French and the British (later joined by Germans, and eventually Americans, Poles, Italians, and even Canadians) peacefully recognized each other’s stakeholdings and claims, and honoured each other’s adventurers and scholars. So much of what we now reflexively condemn as “European Imperialism” was conducted at a level of civilization that is unimaginable today. We ritually sneer at digging practices that were primitive and inexact, forgetting that our own “modern methods” were being devised by these men, as they went along, starting only from rumour and wild surmise.

David Warren, “With Layard to Ninevah”, Essays in Idleness, 2016-07-05.

March 9, 2018

Bad news about the Peltzman Effect and opiate use

Filed under: Health, USA — Tags: , , , — Nicholas @ 03:00

Megan McArdle recounts the US federal government’s attempt to improve automobile safety in the 1960s and the surprisingly mixed results of those efforts on overall safety for drivers (better), pedestrians (worse) and the frequency of non-fatal accidents (higher). Those results were summarized by Sam Peltzman as indicating that most of us have an innate tendency to take more risks when we’re less likely to suffer the costs of those risks (hence, the “Peltzman Effect”). She then talks about a tragic new instance of this in the opiate crisis:

A chemical called naloxone acts as an “opioid antagonist” — which is to say, it reverses the drug’s effects on the body. It can thus save people who have overdosed.

As opioid usage has worsened in the United States, more and more jurisdictions have acted to increase access to naloxone. Not only first responders but also friends, family and even librarians have started to administer it. These state laws were passed at different times, giving researchers Jennifer Doleac and Anita Mukherjee a sort of a natural experiment: They could look at what happened to overdoses in areas that liberalized naloxone access and compare the trends there to places that hadn’t changed their laws.

Their results are grim, to say the least: “We find that broadening Naloxone access led to more opioid-related emergency room visits and more opioid-related theft, with no reduction in opioid-related mortality.”

You can never assume that the results of one study, however well done, are correct. But these results look pretty robust. If they hold up, they would mean that naloxone is not saving lives; all we’re doing is spending a lot of money on naloxone to generate some increase in crime.

It makes a certain amount of sense that the Peltzman Effect would show up particularly strongly in drug users; after all, drugs hijack the brain’s reward system, redirecting it toward drug-seeking even at high personal risk. Drug users, one would think, would be highly likely to recalibrate their risk-taking so that the risk of death remains constant, while the frequency and potency of drug use increases.

The coldly logical response to this would seem to be to discontinue naloxone use. But there’s something repulsive about that conclusion, and Doleac and Mukherjee can’t bring themselves to go there. “Our findings do not necessarily imply that we should stop making Naloxone available to individuals suffering from opioid addiction,” they write, “or those who are at risk of overdose. They do imply that the public health community should acknowledge and prepare for the behavioral effects we find here.”

QotD: Contempt for science

Filed under: Education, Media, Quotations, Science — Tags: , , , — Nicholas @ 01:00

The waging of a “war on science” by right-wing know-nothings has become part of the conventional wisdom of the intelligentsia. Even some Republican stalwarts have come to disparage the GOP as “the party of stupid.” Republican legislators have engaged in spectacles of inanity, such as when Sen. James Inhofe, chair of the Committee on Environment and Public Works, brought a snowball to the Senate floor in 2015 to dispute the fact of global warming, and when Rep. Lamar Smith, chair of the House Committee on Science, Space, and Technology, pulled quotes out of context from peer-reviewed grants of the National Science Foundation so he could mock them (for example, “How does the federal government justify spending over $220,000 to study animal photos in National Geographic?”).

Yet a contempt for science is neither new, lowbrow, nor confined to the political right. In his famous 1959 lecture “The Two Cultures and the Scientific Revolution,” C.P. Snow commented on the disdain for science among educated Britons and called for a greater integration of science into intellectual life. In response to this overture, the literary critic F.R. Leavis wrote a rebuttal in 1962 that was so vituperative The Spectator had to ask Snow to promise not to sue for libel if they published the work.

The highbrow war on science continues to this day, with flak not just from fossil-fuel-funded politicians and religious fundamentalists but also from our most adored intellectuals and in our most august institutions of higher learning. Magazines that are ostensibly dedicated to ideas confine themselves to those arising in politics and the arts, with scant attention to new ideas emerging from science, with the exception of politicized issues like climate change (and regular attacks on a sin called “scientism”). Just as pernicious is the treatment of science in the liberal-arts curricula of many universities. Students can graduate with only a trifling exposure to science, and what they do learn is often designed to poison them against it.

Steven Pinker, “The Intellectual War on Science”, Chronicle of Higher Education, 2018-02-13.

February 28, 2018

Psychology’s replication failures – “many casualties of the replication crisis do indeed bear a strong resemblance to voodoo”

Filed under: Health — Tags: , , , , — Nicholas @ 03:00

In Psychology Today, Lee Jussim says that once upon a time in the benighted, ignorant past, we generally believed in magic. In these more scientific, advanced, de-mystified days, we believe in psychology. He wonders if there’s actually much of a difference between the two:

Are some of the most famous effects in psychology – priming, stereotype threat, implicit bias – based on smoke and mirrors? Does the widespread credibility given such effects in the face of very weak evidence have a weird kinship with supernatural beliefs?

Many findings in psychology are celebrated in part because they were shocking and seemed almost magical. So magical that psychiatrist Scott Alexander argued that many casualties of the replication crisis do indeed bear a strong resemblance to voodoo — the main difference being an appeal to mysterious unobserved unconscious forces rather than mysterious unobserved supernatural ones.

Belief in the efficacy of voodoo itself can by psychologized: Curses work, some say, because believing you are hexed can kill you. There are similar mind-over-matter tales involving implausibly strong effects from placebos and self-affirmations. Priming studies claim that even thinking about the word “retirement” can transfer the weakness of old age into a young body, and make young people walk slower. The idea that people gravitate toward occupations that sound like their names bears a strange resemblance to sympathetic magic: If you name your daughter Suzie, she’s now more likely to wind up selling shells by the seashore, whereas your son Brandon will be a banker.

Supernatural beliefs are a universal feature of human societies. For people in many tribal societies, magic is serious business — a matter of life and death. Sorcerers can make good money by selling their services, while those accused of sorcery might be killed. The same was true in medieval Europe, where many were executed for supposedly using evil magic against their neighbors.

Belief in magic has retreated in modern times. Science has rendered the world less mysterious, technology has given us more effective control over it, and bureaucratic rules make life more predictable. Magic retreated.

Or did it? Any belief as universal as magic may be marvelously adapted to well-worn ruts in the human brain and encouraged by common structures and rhythms of human interaction.

February 27, 2018

The notion of “uploading” your consciousness

Filed under: Health, Science, Technology — Tags: , , , , , — Nicholas @ 03:00

Skeptic author Michael Shermer pours cold water on the dreams and hopes of Transhumanists, Cryonicists, Extropians, and Technological Singularity proponents everywhere:

It’s a myth that people live twice as long today as in centuries past. People lived into their 80s and 90s historically, just not very many of them. What modern science, technology, medicine, and public health have done is enable more of us to reach the upper ceiling of our maximum lifespan, but no one will live beyond ~120 years unless there are major breakthroughs.

We are nowhere near the genetic and cellular breakthroughs needed to break through the upper ceiling, although it is noteworthy that companies like Google’s Calico and individuals like Abrey deGrey are working on the problem of ageing, which they treat as an engineering problem. Good. But instead of aiming for 200, 500, or 1000 years, try to solve very specific problems like cancer, Alzheimer’s and other debilitating diseases.

Transhumanists, Cryonicists, Extropianists, and Singularity proponents are pro-science and technology and I support their efforts but extending life through technologies like mind-uploading not only cannot be accomplished anytime soon (centuries at the earliest), it can’t even do what it’s proponents claim: a copy of your connectome (the analogue to your genome that represents all of your memories) is just that—a copy. It is not you. This leads me to a discussion of…

The nature of the self or soul. The connectome (the scientific version of the soul) consists of all of your statically-stored memories. First, there is no fixed set of memories that represents “me” or the self, as those memories are always changing. If I were copied today, at age 63, my memories of when I was, say, 30, are not the same as they were when I was 50 or 40 or even 30 as those memories were fresh in my mind. And, you are not just your memories (your MEMself). You are also your point-of-view self (POVself), the you looking out through your eyes at the world. There is a continuity from one day to the next despite consciousness being interrupted by sleep (or general anaesthesia), but if we were to copy your connectome now through a sophisticated fMRI machine and upload it into a computer and turn it on, your POVself would not suddenly jump from your brain into the computer. It would just be a copy of you. Religions have the same problem. Your MEMself and POVself would still be dead and so a “soul” in heaven would only be a copy, not you.

Whether or not there is an afterlife, we live in this life. Therefore what we do here and now matters whether or not there is a hereafter. How can we live a meaningful and purposeful life? That’s my final chapter, ending with a perspective that our influence continues on indefinitely into the future no matter how long we live, and our species is immortal in the sense that our genes continue indefinitely into the future, making it all the more likely our species will not go extinct once we colonize the moon and Mars so that we become a multi-planetary species.

February 25, 2018

Masculinity and homicidal violence (aka “Not all men…”)

Filed under: Health, Science — Tags: , , , — Nicholas @ 03:00

In Quillette, William Buckner looks at the violence inherent in the (biological) system. “Help, help, we’re being repressed!”

Understanding patterns of lethal violence among humans requires understanding some important sex differences between males and females. Globally, men are 95 percent of homicide offenders and 79 percent of victims. Sex differences in lethal violence tend to be remarkably consistent, on every continent, across every type of society, from hunter-gatherers to large-scale nation states. In their 2013 study on lethal violence among hunter-gatherers, Douglas Fry and Patrik Söderberg’s data showed that males committed about 96 percent of homicides and were victims 84 percent of the time. In her study on violence in non-state societies, criminologist Amy Nivette shows that, across a number of small-scale pastoralist and agriculturalist societies, males make up 91-98 percent of killers. To illustrate the consistency of this relationship even further: we see the same pattern among chimpanzees, where males make up 92 percent of killers and 73 percent of victims.

To be sure, there is some cross-cultural variation. While I can find no well-studied population where women are known to commit more lethal violence than men, there are some societies where women make up an equal number, or even the majority, of homicide victims. These societies generally seem to have low rates of homicide overall, as the United Nations Office on Drugs and Crime mentions in their 2013 study on global homicide:

    Available data suggest that in countries with very low (and decreasing) homicide rates (less than 1 per 100,000 population), female victims constitute an increasing share of total victims and, in some of those countries, the share of male and female victims appears to be reaching parity.

Hong Kong, with a low homicide rate overall, has a comparatively smaller sex difference in homicide offending, and women make up a majority of homicide victims at 52 percent. Yet even in Hong Kong, males commit 78 percent of reported homicides. The world over, the majority of homicide offenders and victims tend to be reproductive-age males, between their late teens and early 40s.

To understand why this pattern is so consistent across a wide variety of culturally and geographically diverse societies, we need to start by looking at sex differences in reproductive biology.

[…]

Predictably, among humans, males engage in more direct, violent competition for mates than females do, and females provide more caregiving than males do. However, humans are unique in that some male participation in caregiving is ubiquitous across cultures. Human infants are particularly helpless during early development, requiring extensive provisioning and caregiving. Human males face the same tradeoff between securing mating opportunities and providing parental care that males of other species face, and the extent to which males utilize either of these strategies can vary significantly due to social and ecological factors.

Noting these sex differences in reproductive biology and parental investment is important because they help explain why males tend to engage in more violence than females. Aggressively engaging in violent conflict is more likely to reduce a female’s fitness, as it may bring unnecessary danger to her offspring, or cause an injury that may prevent her from reproducing in the future. For a male, however, violent conflict can potentially increase his reproductive success through increases in status, or by aggressively monopolizing access to key resources. Among the Yanomami of the Amazon, and the Nyangatom of East Africa, for example, males who participate in more violence and warfare have increased reproductive success. Even in the contemporary United States, there is evidence that more violent males have more sexual partners.

February 24, 2018

QotD: The use of the [awkward silence] in conversation

Filed under: Health, Quotations — Tags: , — Nicholas @ 01:00

And then there’s [awkward silence]. I learned this one from the psychoanalysts. Nobody likes an awkward silence. If a patient tells you something, and you are awkwardly silent, then the patient will rush to fill the awkward silence with whatever they can think of, which will probably be whatever they were holding back the first time they started talking. You won’t believe how well this one works until you try it. Just stay silent long enough, and the other person will tell you everything. It’s better than waterboarding.

The only problem is when two psychiatrists meet. One of my attendings tried to [awkward silence] me at the same time I was trying to [awkward silence] him, and we ended up just staring at each other for five minutes until finally I broke down laughing.

“I see you find something funny,” he said. “Tell me more.”

Scott Alexander, “3/4”, Slate Star Codex, 2016-07-12.

February 22, 2018

DicKtionary – E is for Eugenics – Otmar von Verschuer

Filed under: Germany, History, Science — Tags: , , , , — Nicholas @ 06:00

TimeGhost
Published on 21 Feb 2018

E for eugenics, pseudo science about race,
Selective breeding of humans can make the world a purer place,
When saying, “that’s scary”, those words are ne’er truer,
Then of the main man today, Otmar von Verschuer.

Hosted by: Indy Neidell
Written by: Spartacus Olsson
Produced and Directed by: Astrid Deinhard
Executive Producers: Bodo Rittenauer, Astrid Deinhard, Indy Neidell, Spartacus Olsson
Camera by: Jonas Klein
Edited by: Spartacus Olsson, Jonas Klein

A TimeGhost chronological documentary produced by OnLion Entertainment GmbH

Dieting and mental health

Filed under: Food, Health — Tags: , — Nicholas @ 05:00

Kaitlin Ugolik discusses her own recent experience of trying a new diet:

We don’t often discuss the mental impact of restrictive diets like Whole30 (no “inflammatory” foods), keto (low carb, high fat) or paleo (foods supposedly eaten during the Paleolithic era). People like to tout the weight loss and mood-boosting effects of these diets, but experts say they can push some of us toward disordered eating.

I tried Whole30 this January, and at first I kind of enjoyed it. I tend to get overwhelmed by options and confused about what’s the latest “right” thing to eat for breakfast, so it was nice to have guidelines. It gave me an excuse to make smoothies and try some new dinner recipes, too.

A few days in, though, I started noticing some disconcerting thoughts. I was reading the labels on everything and starting to think of anything that had any kind of processed sugar — cane sugar, brown rice syrup, anything — as “bad.” I also noticed that some of Whole 30’s carceral language was starting to stick in my head. Foods are labeled as “compliant” or “non-compliant,” for example. Knowing several people who have struggled with eating disorders, I wondered if diets like this, that say you can’t even eat beans or quinoa, might be a gateway to disordered eating for some people. The consensus among the experts I spoke to is that they are.

“All weight-loss diets work against learning to eat ‘normally’ according to appetite cues, which is also called intuitive eating,” said Karen Koenig, a Florida-based social worker who counsels people with eating disorders. “The more we restrict eating—by food type, weighing food, or by counting calories or fat grams—the more we ignore and override our body’s signals for hunger, satisfaction and fullness.”

While some people do benefit from restrictive diets because of their choice-limiting nature, like I did at the beginning, many have a hard time not taking it to the extreme. Most people are taking part in these diets as part of some kind of goal, whether it’s to lose weight, clear up their skin, or just feel better. If (and more likely when) it doesn’t work, it’s normal for anyone to get frustrated. But for people who are already prone to anxiety and obsessive thinking (*raises hand*) or those who have “addictive personalities,” a detox or diet can actually lead to something much more dangerous.

February 18, 2018

The legal loophole that allows profiteering scumbags like Martin Shkreli to gouge the public

Filed under: Bureaucracy, Business, Government, Health, USA — Tags: , , — Nicholas @ 03:00

The US pharmaceutical market is a long way from a freely competitive environment, largely due to the amount of regulatory oversight required by lawmakers and enforced by the Food and Drug Administration (FDA). Among all the regulatory checks and balances, there’s one weird trick that allows predatory companies to reap excess profits legally — the “restricted distribution” loophole:

For immunocompromised adult patients who have the toxoplasmosis parasite, the FDA recommends taking 50 to 75 milligrams of Daraprim a day for up to three weeks, followed by half that dosage for an additional four to five weeks. So at the high end, an adult course of Daraprim therapy for a U.S. patient used to cost around $1,350 total.

While that might not seem cheap, it was a drop in the bucket compared to the cost after Turing Pharmaceuticals, Shkreli’s company, bought the rights to Daraprim and jacked the price up to $750 per pill in 2015. That move increased the cost of one course of treatment to around $75,000.

At that point you might have expected another company to jump in and start offering a generic version of the drug. But Shkreli used a regulatory loophole to keep that from happening.

You see, when a generic manufacturer wants to create a cheap version of a branded drug, it has to buy thousands of doses from the manufacturer in order to run comparison tests. Generic manufacturers use the results of these tests to prove to the FDA that their version is identical to the branded drug that the agency has already approved.

More often than not, the company that holds the marketing and distribution rights to a branded drug will sell those comparison doses to the generic manufacturer without being obstructionist, because that’s the trade-off for receiving a 20-year monopoly by way of a drug patent: The branded manufacturer gets to charge whatever they want for years and years without facing competition, and in exchange for that government-backed monopoly, it’s supposed to sell equivalency samples to generic companies.

But what if the company is run by an unscrupulous asshole like Martin Shkreli? Then it might opt to put the drug into what’s called “restricted distribution,” which means no distributor anywhere can sell comparison samples to a generic manufacturer.

The FDA originally created the concept of restricted distribution to limit the availability of drugs that might be dangerous. Methadone, for instance, was first approved in the 1940s as a painkiller. In the 1970s, the FDA restricted its availability because regulators didn’t want the opioid used for anything other than the treatment of opioid dependence. Even today, methadone can be dispensed only in highly regulated settings and only for one approved reason.

In 2007, Congress empowered the FDA to create an entire system of safety controls beyond restricted distribution, and the agency now requires the manufacturers of certain substances to develop Risk Evaluation and Mitigation Strategies (REMS) to prevent misuse and abuse of potentially problematic compounds.

The list of approved drugs that the FDA says must have an REMS is here. Daraprim is not on that list. You can’t get high off it. It’s not habit forming. Yes, the FDA label says it can be carcinogenic after long periods of use, and that it might cause birth defects if used in high doses by pregnant women. These potential effects are serious, but there is no post-market data suggesting that Daraprim is causing more harm than benefit in the intended patient population. Shkreli’s company put Daraprim into restricted distribution to boost their profits, not protect patients.

February 16, 2018

Differences in interest drives gender disparity in STEM fields

Filed under: Education, Science, Technology — Tags: , , , — Nicholas @ 03:00

David C. Geary and Gijsbert Stoet examine the STEM fields’ renowned gender disparities:

Many academics in the modern world seem obsessed with the sex difference in engagement with science, technology, mathematics, and engineering (STEM) fields. Or rather they are obsessed with the fact that there are more men than women in some of these fields. There is particular concern about the lack of women in prestigious STEM fields, such as Ph.D.-level faculty positions, but surprisingly there is no concern about the under-representation of women in lower-level technical jobs, such as car mechanics or plumbing.

The concerned academics have been especially effective in convincing others, or at least intimidating them, into accepting their preferred interpretations regarding the source of these sex differences (as illustrated in the Google memo debate). These interpretations are not surprising and they include sexism, stereotype threat, and more recently implicit bias and microaggression. Each of these ideas has gained traction in the mainstream media and in many academic circles but their scientific foundations are shaky. In this essay, we’ll provide some background on the STEM controversy and consider multiple factors that might contribute to these sex differences.

[…]

We’ve recently found that countries renowned for gender equality show some of the largest sex differences in interest in and pursuit of STEM degrees, which is not only inconsistent with an oppression narrative, it is positive evidence against it. Consider that Finland excels in gender equality, its adolescent girls outperform boys in science, and it ranks near the top in European educational performance. With these high levels of educational performance and overall gender equality, Finland is poised to close the sex differences gap in STEM. Yet, Finland has one of the world’s largest sex differences in college degrees in STEM fields. Norway and Sweden, also leading in gender equality rankings, are not far behind. This is only the tip of the iceberg, as this general pattern of increasing sex differences with national increases in gender equality is found throughout the world.

The recent uptick in interest in concepts such as stereotype threat, implicit bias, and microaggression may be a reaction to the low female STEM participation in highly developed nations. At one time, there were substantive social and educational impediments to women’s participation in these (and other) fields, but as explicit sexism and restricted educational opportunities faded into history, the sex differences (e.g., fewer women than men physicists) attributed to them should have faded as well. Some of them have even reversed, such that more women than men attend and graduate from college and women may now have structural advantages (e.g., hiring practices) in STEM fields. Even with these changes, many other sex differences remain or have become larger over time. The latter are serious problems for anyone with strong beliefs about purely or largely social influences on sex differences; if the obvious social causes have been addressed, then there must be other, more subtle oppressive factors afoot. This is where stereotype threat, implicit bias, microaggression and related concepts enter the oppression narrative.

We believe that with economic development and advances in human rights, including gender equality, people are better able to pursue their individual interests and in doing so more basic sex differences are more fully expressed. The differences in STEM are related in part to student’s personal and occupational interests and relative academic strengths. Sex differences in occupational interests are large, well-documented, and reflect a more basic sex difference in interest in things versus people. Men prefer occupations that involve working with things (e.g., engineering, mechanics) and abstract ideas (e.g., scientific theory) and women prefer working with and directly contributing to the wellbeing of others (e.g., physician, teacher). The sex difference in interest in people extends to a more general interest in living things, which would explain why women who are interested in science are much more likely to pursue a career in biology or veterinary medicine than computer science.

Programs designed to steer women into inorganic STEM fields would in effect steer these same women away from the life sciences. Such programs would, in our opinion, only be justifiable if women are not provided a fair opportunity to pursue inorganic STEM fields (for which there is no good evidence). The main argument from gender activists is that inorganic STEM fields are a better choice for women either because these jobs lead to higher incomes or that there is a labor market demand for them. Both arguments are fundamentally capitalist and dehumanizing in the sense that considerations of personal interest are overridden by considerations of societal demand. This is ironic, given that the agenda arguing for more women in STEM seems most popular among left-leaning people.

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