Published on 24 Jun 2014
In this video, Professor Boudreaux explains how the specialization of knowledge helped his two-year old son overcome a life-threatening illness. The science of medicine has enjoyed significant progress since the 19th century thanks to the vast size of the market and demand for health care services. Despite his foresight, Adam Smith never could have imagined the degree of expertise held by some of today’s medical specialists.
September 6, 2015
How the Division of Knowledge Saved My Son’s Life (Everyday Economics 3/7)
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September 5, 2015
The subtle lure of “research” that confirms our biases
Megan McArdle on why we fall for bogus research:
Almost three years ago, Nobel Prize-winning psychologist Daniel Kahneman penned an open letter to researchers working on “social priming,” the study of how thoughts and environmental cues can change later, mostly unrelated behaviors. After highlighting a series of embarrassing revelations, ranging from outright fraud to unreproducible results, he warned:
For all these reasons, right or wrong, your field is now the poster child for doubts about the integrity of psychological research. Your problem is not with the few people who have actively challenged the validity of some priming results. It is with the much larger population of colleagues who in the past accepted your surprising results as facts when they were published. These people have now attached a question mark to the field, and it is your responsibility to remove it.
At the time it was a bombshell. Now it seems almost delicate. Replication of psychology studies has become a hot topic, and on Thursday, Science published the results of a project that aimed to replicate 100 famous studies — and found that only about one-third of them held up. The others showed weaker effects, or failed to find the effect at all.
This is, to put it mildly, a problem. But it is not necessarily the problem that many people seem to assume, which is that psychology research standards are terrible, or that the teams that put out the papers are stupid. Sure, some researchers doubtless are stupid, and some psychological research standards could be tighter, because we live in a wide and varied universe where almost anything you can say is certain to be true about some part of it. But for me, the problem is not individual research papers, or even the field of psychology. It’s the way that academic culture filters papers, and the way that the larger society gets their results.
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September 4, 2015
Slate: Testosterone changes the brain
Perhaps it’s not just a social construct after all:
However much we’d like to think of gender as a social construct, science suggests that real differences do exist between female and male brains. The latest evidence: a first-of-its-kind European study that finds that the female brain can be drastically reshaped by treating it with testosterone over time.
Research has shown that women have the advantage when it comes to memory and language, while men tend to have stronger spatial skills (though this too has been disputed). But due to ethical restrictions, no study had been able to track the direct effect that testosterone exposure has on the brain — until now. Using neuroimaging, Dutch and Austrian researchers found that an increase in this potent hormone led to shrinkage in key areas of the female (transitioning to male) brain associated with language. They presented their findings at last week’s annual meeting of the European College of Neuropsychopharmacology in Amsterdam.
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September 2, 2015
August 29, 2015
We need a new publication called The Journal of Successfully Reproduced Results
We depend on scientific studies to provide us with valid information on so many different aspects of life … it’d be nice to know that the results of those studies actually hold up to scrutiny:
One of the bedrock assumptions of science is that for a study’s results to be valid, other researchers should be able to reproduce the study and reach the same conclusions. The ability to successfully reproduce a study and find the same results is, as much as anything, how we know that its findings are true, rather than a one-off result.
This seems obvious, but in practice, a lot more work goes into original studies designed to create interesting conclusions than into the rather less interesting work of reproducing studies that have already been done to see whether their results hold up.
Everyone wants to be part of the effort to identify new and interesting results, not the more mundane (and yet potentially career-endangering) work of reproducing the results of older studies:
Why is psychology research (and, it seems likely, social science research generally) so stuffed with dubious results? Let me suggest three likely reasons:
A bias towards research that is not only new but interesting: An interesting, counterintuitive finding that appears to come from good, solid scientific investigation gets a researcher more media coverage, more attention, more fame both inside and outside of the field. A boring and obvious result, or no result, on the other hand, even if investigated honestly and rigorously, usually does little for a researcher’s reputation. The career path for academic researchers, especially in social science, is paved with interesting but hard to replicate findings. (In a clever way, the Reproducibility Project gets around this issue by coming up with the really interesting result that lots of psychology studies have problems.)
An institutional bias against checking the work of others: This is the flipside of the first factor: Senior social science researchers often actively warn their younger colleagues — who are in many cases the best positioned to check older work—against investigating the work of established members of the field. As one psychology professor from the University of Southern California grouses to the Times, “There’s no doubt replication is important, but it’s often just an attack, a vigilante exercise.”
[…]
Small, unrepresentative sample sizes: In general, social science experiments tend to work with fairly small sample sizes — often just a few dozen people who are meant to stand in for everyone else. Researchers often have a hard time putting together truly representative samples, so they work with subjects they can access, which in a lot of cases means college students.
A couple of years ago, I linked to a story about the problem of using western university students as the default source of your statistical sample for psychological and sociological studies:
A notion that’s popped up several times in the last couple of months is that the easy access to willing test subjects (university students) introduces a strong bias to a lot of the tests, yet until recently the majority of studies disregarded the possibility that their test results were unrepresentative of the general population.
August 28, 2015
QotD: The unusually lucky 20th century, meteorologically speaking
… I read a lot of history and thus know a fair bit about how weather impact has been perceived by humans over time. It is a fact that the 20th century was an abnormally lucky hundred years, meteorologically speaking. The facts I managed to jam into tweets included (a) the superstorm that flooded 300 square miles of the Central Valley in California in the 1860s, (b) rainfall levels we’d consider drought conditions were normal in the U.S. Midwest before about 1905, and (c) storms of a violence we’d find hard to believe were commonly reported in the 1800s. I had specifically in mind something I learned from the book Wicked River: The Mississippi When It Last Ran Wild, which relays eyewitness accounts of thunderstorms so intense that travelers had to steeple their hands over their noses in order to breathe air instead of water; but a sense that storms of really theatrical violence were once common comes through in many other histories.
We had a quiet century geophysically as well — no earthquakes even nearly as bad as the New Madrid event of 1812, which broke windows as far north as Montreal. And no solar storms to compare with the Carrington Event of 1859, which seriously damaged the then-nascent telegraph infrastructure and if it recurred today would knock out power and telecomms so badly that we’d be years recovering and casualties would number in the hundreds of thousands, possibly the millions.
(I’m concentrating on 19th-century reports because those tended to be well-documented, but earlier records tell us it was the 20th century calm that was unusual, not the 19th-century violence.)
The awkward truth is that there are very large forces in play in the biosphere, and when they wander out of the ranges we’re adapted to, we suffer and die a lot and there really isn’t a great deal we can do about it; we don’t operate at the required energy scales. For that matter, I can think of several astronomical catastrophes that could be lurking just outside our light-cone only to wipe out all multicellular life on Earth next week. Reality is like that.
Eric S. Raymond, “Heavy weather and bad juju”, Armed and Dangerous, 2011-02-03.
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August 26, 2015
Organic food recalls on the rise
It must be a trend if even the New York Times is reporting on the increasing number of food safety recalls involving organic food:
New data collected by Stericycle, a company that handles recalls for businesses, shows a sharp jump in the number of recalls of organic food products.
Organic food products accounted for 7 percent of all food units recalled so far this year, compared with 2 percent of those recalled last year, according to data from the Food and Drug Administration and the Department of Agriculture that Stericycle uses to compile its quarterly report on recalls.
In 2012 and 2013, only 1 percent of total units of food recalled were organic.
Kevin Pollack, a vice president at Stericycle, said the growing consumer and corporate demand for organic ingredients was at least partly responsible for the increase.
“What’s striking is that since 2012, all organic recalls have been driven by bacterial contamination, like salmonella, listeria and hepatitis A, rather than a problem with a label,” Mr. Pollack said. “This is a fairly serious and really important issue because a lot of consumers just aren’t aware of it.”
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August 25, 2015
Roger Kimball says Elon Musk is crazy
Oh, sorry, he actually said Musk is “crazy like a visionary“:
I am an unlikely fan of Elon Musk, the flamboyant, Steve Jobs-like (some would say Tony Stark-like) entrepreneur behind SpaceX, SolarCity, Tesla Motors, and other enterprises that seemed like starry-eyed impossibilities a scant decade ago. Musk’s two governing passions, he has said repeatedly, are “sustainable transport” to battle “global warming” and finding a way to make mankind an interplanetary species, beginning with a space colony on Mars.
For my part, the word “sustainable” has me reaching, if not for my revolver, then at least for an air-sickness bag. I regard the whole Green Lobby as a cocktail composed of three parts moralistic hysteria mixed with a jigger of high-proof cynical opportunism (take a look at Al Gore’s winnings from the industry) fortified with a dash of beady-eyed left-wing redistributionist passion. You can never be Green enough, Comrade, and if the data show a 20-year “hiatus” in global warming (so much for Michael Mann’s infamous hockey stick), that’s no reason not to insist that capitalist powerhouses like the United States drastically curtail their CO2 emissions right now, today, while giving egregious polluters like China a decade or more to meet its quotas.
No, when it comes to energy, I often quote, sometimes with attribution, the Manhattan Institute’s Robert Bryce: what the world needs now is cheap, abundant energy, period, full stop, end of discussion. My motto is: frack early, frack often. Do you want to help the poor/clean up the environment/save the spotted wildebeest? Then you need economic growth, and to achieve that you need energy, which at the moment means you need fracking. Q.E.D.
When it comes to interplanetary travel, I suspect that Musk’s passion for transforming us into “space-faring” creatures was heavily influenced by his youthful reading of Isaac Asimov, Robert Heinlein, and (one of his favorites) The Hitchhiker’s Guide to the Galaxy. Not that those adolescent chestnuts necessarily argue against the plausibility of his ambitions. Behind Musk’s enthusiasm for space colonization is a worry that a future “extinction event” might delete human consciousness from the emporium of the universe.
For what it’s worth, I’m very much split on Musk and his works: I generally agree with his desire to help get humanity expanding beyond our single, frail planet … I just wish he wasn’t guzzling down government subsidies to get there. I’ve read the book Kimball is reviewing (Ashlee Vance’s Elon Musk: Tesla, SpaceX, and the Quest for a Fantastic Future), and I certainly feel I got my money’s worth from the purchase … Musk is potentially a very great man. Right now, he’s a pretty good man who still takes everything he can get from the government.
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August 23, 2015
The chemistry of ice cream
Compound Interest on the chemical structure of ice cream:
Click to see the full-sized original
Ice cream is a mainstay of summer – for many, a trip to the beach would be incomplete without one. Despite its seeming simplicity, ice cream is a prime example of some fairly complex chemistry. This graphic takes a look at some of the ingredients that go into ice cream, and the important role they play in creating the finished product. There’s a lot to talk about – whilst the graphic gives an overview, read on for some in-depth ice cream science!
Initially, it might be hard to believe that ice cream could be all that complicated. After all, it’s essentially composed of three basic ingredients: milk, cream, and sugar. How complex can the mixing of three ingredients really be? As it turns out, the answer is: very! Simply mixing the ingredients together, then freezing them, isn’t enough to make a good ice cream. To understand why this is, we’re going to need to talk about each of the component ingredients in turn, and what they bring to the table.
Ice cream is a type of emulsion, a combination of fat and water that usually wouldn’t mix together without separating. However, in an emulsion, the very small droplets of fat are dispersed through the water, avoiding this separation. The manner in which this is accomplished is a result of the chemical properties of molecules in the emulsion.
The fat droplets in ice cream come from the cream used to make it. Fats are largely composed of a class of molecules called triglycerides, with very small amounts (less than 2%) of other molecules such as phospholipids and diglycerides. The triglycerides are made up of a glycerol molecule combined with three fatty acid molecules, as shown in the graphic. The melting temperature of the fats used in ice cream is quite important, as fats that melt at temperatures that are too high give a waxy feel in the mouth, whilst it’s difficult to make stable ice cream with those that melt at too low a temperature. Luckily, dairy fat falls just in the right range! As it happens, you can also make ice cream with palm oil and coconut oil, as their melting temperatures are similar.
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August 20, 2015
One of the slickest marketing campaigns of our time
In Forbes, Henry I. Miller and Drew L. Kershen explain why they think organic farming is, as they term it, a “colossal hoax” that promises far more than it can possibly deliver:
Consumers of organic foods are getting both more and less than they bargained for. On both counts, it’s not good.
Many people who pay the huge premium — often more than 100% — for organic foods do so because they’re afraid of pesticides. If that’s their rationale, they misunderstand the nuances of organic agriculture. Although it’s true that synthetic chemical pesticides are generally prohibited, there is a lengthy list of exceptions listed in the Organic Foods Production Act, while most “natural” ones are permitted. However, “organic” pesticides can be toxic. As evolutionary biologist Christie Wilcox explained in a 2012 Scientific American article (“Are lower pesticide residues a good reason to buy organic? Probably not.”): “Organic pesticides pose the same health risks as non-organic ones.”
Another poorly recognized aspect of this issue is that the vast majority of pesticidal substances that we consume are in our diets “naturally” and are present in organic foods as well as non-organic ones. In a classic study, UC Berkeley biochemist Bruce Ames and his colleagues found that “99.99 percent (by weight) of the pesticides in the American diet are chemicals that plants produce to defend themselves.” Moreover, “natural and synthetic chemicals are equally likely to be positive in animal cancer tests.” Thus, consumers who buy organic to avoid pesticide exposure are focusing their attention on just one-hundredth of 1% of the pesticides they consume.
Some consumers think that the USDA National Organic Program (NOP) requires certified organic products to be free of ingredients from “GMOs,” organisms crafted with molecular techniques of genetic engineering. Wrong again. USDA does not require organic products to be GMO-free. (In any case, the methods used to create so-called GMOs are an extension, or refinement, of older techniques for genetic modification that have been used for a century or more.)
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August 17, 2015
Flying Monkeys …. in spaaaaaaace!
Published on 11 Aug 2015
On June 4th, 2015 we sent Flying Monkeys SuperCollider 2.0 DIPA craft beer into space just for kicks. After 3 hours in flight it came back to earth from 109,780 feet. The footage is unbrew-lieveable!
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Food fears and GMOs
Henry I. Miller and Drew L. Kershen on the widespread FUD still being pushed in much of the mainstream media about genetically modified organisms in the food supply:
New York Times nutrition and health columnist Jane Brody recently penned a generally good piece about genetic engineering, “Fears, Not Facts, Support GMO-Free Food.” She recapitulated the overwhelming evidence for the importance and safety of products from GMOs, or “genetically modified organisms” (which for the sake of accuracy, we prefer to call organisms modified with molecular genetic engineering techniques, or GE). Their uses encompass food, animal feed, drugs, vaccines and animals. Sales of drugs made with genetic engineering techniques are in the scores of billions of dollars annually, and ingredients from genetically engineered crop plants are found in 70-80 percent of processed foods on supermarket shelves.
Brody’s article had two errors, however. The first was this statement, in a correction that was appended (probably by the editors) after the article was published:
The article also referred imprecisely to regulation of GMOs by the Food and Drug Administration and the Environmental Protection Agency. While the organizations regulate food from genetically engineered crops to ensure they are safe to eat, the program is voluntary. It is not the case that every GMO must be tested before it can be marketed.
In fact, every so-called GMO used for food, fiber or ornamental use is subject to compulsory case-by-case regulation by the Animal and Plant Health Inspection Service (APHIS) of USDA and many are also regulated by the Environmental Protection Agency (EPA) during extensive field testing. When these organisms — plants, animals or microorganisms — become food, they are then overseen by the FDA, which has strict rules about misbranding (inaccurate or misleading labeling) and adulteration (the presence of harmful substances). Foods from “new plant varieties” made with any technique are subject to case-by-case premarket FDA review if they possess certain characteristics that pose questions of safety. In addition, food from genetically engineered organisms can undergo a voluntary FDA review. (Every GE food to this point has undergone the voluntary FDA review, so FDA has evaluated every GE food on the market).
The second error by Brody occurred in the very last words of the piece, “the best way for concerned consumers to avoid G.M.O. products is to choose those certified as organic, which the U.S.D.A. requires to be G.M.O.-free.” Brody has fallen victim to a common misconception; in fact, the USDA does not require organic products to be GMO-free.
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Common metal alloys
Compound Interest looks at the chemical composition of some common metal alloys:
Click to see the full-sized original
Today’s post looks at an aspect of chemistry we come across every day: alloys. Alloys make up parts of buildings, transport, coins, and plenty of other objects in our daily lives. But what are the different alloys we use made up of, and why do we use them instead of elemental metals? The graphic answers the first of these questions, and in the post we’ll try and answer the second.
First, a little on what alloys are, for anyone unfamiliar with the term. Alloys are a mixture of elements, where at least one of the elements is a metal. There are over 80 metals in the periodic table of elements, and we can mix selections of these different metals in varying proportions, sometimes with non-metals too, to create alloys. Note the use of the word mixture: in the vast majority of cases, alloys are simply intermixed elements, rather than elements that are chemically bonded together.
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August 15, 2015
Science in the media – from “statistical irregularities” to outright fraud
In The Atlantic, Bourree Lam looks at the state of published science and how scientists can begin to address the problems of bad data, statistical sleight-of-hand, and actual fraud:
In May, the journal Science retracted a much-talked-about study suggesting that gay canvassers might cause same-sex marriage opponents to change their opinion, after an independent statistical analysis revealed irregularities in its data. The retraction joined a string of science scandals, ranging from Andrew Wakefield’s infamous study linking a childhood vaccine and autism to the allegations that Marc Hauser, once a star psychology professor at Harvard, fabricated data for research on animal cognition. By one estimate, from 2001 to 2010, the annual rate of retractions by academic journals increased by a factor of 11 (adjusting for increases in published literature, and excluding articles by repeat offenders). This surge raises an obvious question: Are retractions increasing because errors and other misdeeds are becoming more common, or because research is now scrutinized more closely? Helpfully, some scientists have taken to conducting studies of retracted studies, and their work sheds new light on the situation.
“Retractions are born of many mothers,” write Ivan Oransky and Adam Marcus, the co-founders of the blog Retraction Watch, which has logged thousands of retractions in the past five years. A study in the Proceedings of the National Academy of Sciences reviewed 2,047 retractions of biomedical and life-sciences articles and found that just 21.3 percent stemmed from straightforward error, while 67.4 percent resulted from misconduct, including fraud or suspected fraud (43.4 percent) and plagiarism (9.8 percent).
Surveys of scientists have tried to gauge the extent of undiscovered misconduct. According to a 2009 meta-analysis of these surveys, about 2 percent of scientists admitted to having fabricated, falsified, or modified data or results at least once, and as many as a third confessed “a variety of other questionable research practices including ‘dropping data points based on a gut feeling,’ and ‘changing the design, methodology or results of a study in response to pressures from a funding source’”.
As for why these practices are so prevalent, many scientists blame increased competition for academic jobs and research funding, combined with a “publish or perish” culture. Because journals are more likely to accept studies reporting “positive” results (those that support, rather than refute, a hypothesis), researchers may have an incentive to “cook” or “mine” their data to generate a positive finding. Such publication bias is not in itself news — back in 1987, a study found that, compared with research trials that went unpublished, those that were published were three times as likely to have positive results. But the bias does seem to be getting stronger: a more recent study of 4,600 research papers found that from 1990 to 2007, the proportion of positive results grew by 22 percent.
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August 14, 2015
QotD: When “the science” shows what you want it to show
To see what I mean, consider the recent tradition of psychology articles showing that conservatives are authoritarian while liberals are not. Jeremy Frimer, who runs the Moral Psychology Lab at the University of Winnipeg, realized that who you asked those questions about might matter — did conservatives defer to the military because they were authoritarians or because the military is considered a “conservative” institution? And, lo and behold, when he asked similar questions about, say, environmentalists, the liberals were the authoritarians.
It also matters because social psychology, and social science more generally, has a replication problem, which was recently covered in a very good article at Slate. Take the infamous “paradox of choice” study that found that offering a few kinds of jam samples at a supermarket was more likely to result in a purchase than offering dozens of samples. A team of researchers that tried to replicate this — and other famous experiments — completely failed. When they did a survey of the literature, they found that the array of choices generally had no important effect either way. The replication problem is bad enough in one subfield of social psychology that Nobel laureate Daniel Kahneman wrote an open letter to its practitioners, urging them to institute tougher replication protocols before their field implodes. A recent issue of Social Psychology was devoted to trying to replicate famous studies in the discipline; more than a third failed replication.
Let me pause here to say something important: Though I mentioned bias above, I’m not suggesting in any way that the replication problems mostly happen because social scientists are in on a conspiracy against conservatives to do bad research or to make stuff up. The replication problems mostly happen because, as the Slate article notes, journals are biased toward publishing positive and novel results, not “there was no relationship, which is exactly what you’d expect.” So readers see the one paper showing that something interesting happened, not the (possibly many more) teams that got muddy data showing no particular effect. If you do enough studies on enough small groups, you will occasionally get an effect just by random chance. But because those are the only studies that get published, it seems like “science has proved …” whatever those papers are about.
Megan McArdle, “The Truth About Truthiness”, Bloomberg View, 2014-09-08.
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