Quotulatiousness

June 28, 2024

The weird and the W.E.I.R.D. gather at Vibecamp

Filed under: Technology, USA — Tags: , , , , , , — Nicholas @ 03:00

Kulak, just back from a road trip to visit two pretty far offbeat gatherings, writes about what she heard and saw at Vibecamp:

VibeCamp is maybe the extreme intersection of Rationalist, Post-Rat, Effective Altruism, Silicon Valley, Quant Finance, and 5-10 other Cyber-Left, Grey-Tribe, autistic-centrist, techno-optimist blogging/twitter world. […]

Given that setup you could probably imagine the two overwhelming facts about Vibecamp:

  1. With rare exception everyone in attendance was shockingly intelligent. At random points throughout the festival I was having deep dive conversation on the geostrategic situation in Israel, the effects of Interest rate increases on venture capital, early 20th century Canadian poetry, and the fate of the petrodollar and the nature of Foreign Exchange markets.
  2. With rare exception everyone in attendance was incredibly weird. Some in very obvious ways visible at 100 paces, some in little uncanny ways it might take you an hour to isolate and identify.

[…]

The shape of the people jumps out at you. There were an incredible number of normal and average looking people, and a much lower portion of obese and Amerifat body-types than almost anywhere else in the US… Perhaps owing to the extreme intelligence and incomes of those involved … But in about 30-45% of people in attendance there’s just some unusual distortion of body proportions that would be remarkable and memorable encountered in an individual, but when assembled together gave the White and Jewish attendees (a combined 90+% of the total) the look that they were all descended from some unusual gothic ethnicity you couldn’t quite put your finger on. Some strange isolated country bordering The Netherlands, Ireland, Estonia, Romania, and the Basque region of Spain … That they’d all come from whatever part of the old country the Adams Family comes from.

[…]

These unusual heights (or lack there-of) were exaggerated by recurring extremes of bodyfat percentage, with several of the attendees (male, female, and between) having a spider-like absence of body fat entirely denoting some unusual hormonal profile expressed in a true kaleidoscope of personalities and interests.

This was expressed most keenly in the faces in which latent autism, and the aforementioned hormonal oddities, were expressed in large eyes and other unusual features, resting positions, and expression creases. Which weren’t all necessarily unattractive, but gave most of the women (and a good percentage of the men) a rather spaced out looks which remained somehow unique in each instance … As if they were all on another planet, but each a very different one from the one each other was on.

Thankfully with psychedelics and other pharmaceuticals they seemed able to meet up on a few mutually agreeable worlds.

[…]

Vibecamp attracts a great deal of biohackers and supplements freaks. Men, women, and others of extreme nutritional theories … and while some of them look like their theories haven’t panned out (the vegans) some look like they’ve discovered the Holy Grail.

This extreme bifurcation and assemblage of extremes was expressed right down to their vehicles… Walking through the parking lot there were $100,000 CyberTrucks and sportscars, whereas 1-2 cars down the line from them there were vehicles practically ripped apart with the engine showing under bodywork that’d long ago been scattered across some guardrail, reassembled just enough to (somehow) get back on the road but with not a dime spent on restoring it’s appearance. This wasn’t 1 car, this was a TYPE of car at the festival. Denoting in the owners some combination of MacGyver resourcefulness, Chadlike indifference, autistic obliviousness, and Victorian Frugality that I can’t but admire … (Or I suppose, possibly, extreme motor impairment. I don’t know that these accidents didn’t happen ON THE WAY to the festival)

[…]

The broken heterosexual male-nerd anxiety and tentativeness around sex and other forms of human interaction and intimacy could be cut with a knife … And it wasn’t like everyone had all been corralled and lectured night one or anything of the sort, somehow this broken progressive Dysgenic (actively failing to generate) culture had infected the urban male technological elite, from Bay Area techfounders, to New York Medical Experts, to DC Military Industrial Complex people, to British Forex Traders, to Dutch and Australians visiting the US for the first time … All of them had had that instinctive flinch trained into them … Some of the Wealthiest, Oddest, Most intelligent, and a small handful of the most attractive men in the world … had all been broken like horses, to flinch and start moving the minute the riding crop is grabbed.

Heartbreaking.

There’s an irony that the places which most engage in therapy language and most proudly proclaim their “acceptance” are almost always the most unforgiving … My friend continued to crash VibeCamp events after they tried to kick him out, and he might have been one of the only people in VibeCamp history to start dating a girl at the festival … (not a man to receive a priestly censor), but the sensitive nerdy men I encountered, with well meaning hearts and souls for poetry, hopeless.

So while I had a blast and enjoyed myself I certainly don’t expect it to be a culture that’s still there in 20-30 years, The people there will maybe produce 100-200 offspring in that time for every 500 that actually attended. If that.

February 19, 2023

Andrew Sullivan on the legacy media’s coverage of transgender issues

Filed under: Britain, Health, Media, Politics, USA — Tags: , , , , , , , , — Nicholas @ 05:00

In the free portion of his Weekly Dish, Andrew Sullivan looks at how the legacy media chooses to cover (or ignore) different aspects of pre-teen and teenage transgenderism:

Two people at EuroPride 2019 in Vienna holding an LGBTQ+ pride rainbow flag featuring a design by Daniel Quasar; this variation of the rainbow flag was initially promoted as “Progress” a PRIDE Flag Reboot.
Photo by Bojan Cvetanović via Wikimedia Commons.

One more criticism of the letter. It uses the terrible history of the [New York Times] on coverage of gay men and AIDS in the 20th century as equivalent to the reporting of Bazelon, Baker, et al, today. This is unhinged. Transgender people today are fully covered under the Civil Rights Act; in the 1980s, gays had nothing. In the 1980s and 1990s, the NYT opposed using the word “gay” because it legitimized homosexuality in some way; today the NYT prints “queer” or “trans” or LGBTQ+ in almost every other article.

Today, the paper has published a mountain of empathetic coverage of trans people — over 800 stories in the past year. Since January 1, the NYT has run a moving profile about a trans man in Mexico; a celebration of “queer” life in Alabama by a trans staffer; an exploration of nonbinary fashion; a critical orgasm over “queer” theater; and a news story explaining that “the flood of [trans-related] legislation is part of a long-term campaign by national groups that see transgender rights as an issue on which they can harness voter anger”. Comparing this with A.M. Rosenthal’s reign of homophobic terror and censorship is just obscene.

One historical analogy does seem salient to me, though: the drugs they now give to gender-dysphoric teens are very closely related to the drugs they used to “cure” Alan Turing of his gayness. Every time I think of that I shudder.

And this attempt to suppress reporting on the subject comes at a very strange time. Next week, a new book will be published about the Tavistock Centre, the place responsible for the medical and psychological treatment of children with gender dysphoria in Britain. It’s written by a liberal female journalist, Hannah Barnes, of a flagship British documentary show, Newsnight.

Her book exposes a huge medical scandal, in which countless children were put on puberty blockers with almost no psychological evaluation, and with rates of autism and domestic abuse that were already through the roof. It shows what happened when the new affirmation-only puberty-blocker experiment, only begun in the late 1990s, was left to run its course, with no opposition and no dissent allowed. Check out an extract here. Here’s where I sat up straight:

    Clinicians recall multiple instances of young people who had suffered homophobic bullying at school or at home, and then identified as trans. According to the clinician Anastassis Spiliadis, “so many times” a family would say, “Thank God my child is trans and not gay or lesbian.” Girls said, “When I hear the word ‘lesbian’ I cringe”, and boys talked to doctors about their disgust at being attracted to other boys.

    When Gids [the Gender Identity Development Service] asked adolescents referred to the service in 2012 about their sexuality, more than 90 per cent of females and 80 per cent of males said they were same-sex attracted or bisexual. Bristow came to believe that Gids was performing “conversion therapy for gay kids” and there was a bleak joke on the team that there would be “no gay people left at the rate Gids was going”.

Just think about that for a second. And remember that gay groups cheer this on; and several gay writers put their names to the letter. What a massive reckoning may be in store for them. If any of this pans out, and gay groups have endorsed it, it could easily be the greatest scandal in the history of the gay rights movement.

More than a third of the kids pushed onto the trans track had autism, sometimes severe. Others were victims of domestic abuse: “[A natal girl] who’s being abused by a male, I think a question to ask is whether there’s some relationship between identifying as male and feeling safe”, one clinician at the center said. No questions about other aspects of a child’s mental health were considered if the kid was identifying as the opposite sex. And this took place in a socialized system, with constant oversight, and no massive financial incentives to treat children. Just imagine what could be happening in the US private system where trans patients are among the most lucrative to have in your care, and are under treatment their entire life.

[…]

One obvious area for research: why have the sex ratios shifted so radically in the past decade or so — with girls now vastly outstripping boys in the young patients involved? Why the explosion in requests? It’s far more dramatic and skewed to one sex than it would be if merely a function of declining stigma. Yet for woke journalists, it’s all Principal Skinner: “Let’s have no more curiosity about this bizarre cover-up.”

Something is going on among teen girls more generally. The CDC just issued a frightening new report:

    Nearly 3 in 5 teen girls (57%) said they felt “persistently sad or hopeless”. That’s the highest rate in a decade. And 30% said they have seriously considered dying by suicide — a percentage that’s risen by nearly 60% over the past 10 years.

Now check out Jamie Reed’s and Tavistock’s overwhelmingly female, often deeply unhappy, clients. Is there a connection? I don’t know. What I do know is that it’s the job of the media to find out, and not to shut itself down.

The lobby groups and often well-intentioned doctors who have pioneered this massive experiment on children will naturally resist any idea they have been facilitating abuse, or concede any points — because as soon as they confess doubt, the whole house of cards can come tumbling down; and lawsuits alone could end the practice very quickly. The Democrats and the Biden administration have locked themselves to the idea that this kind of treatment is a no-brainer and never does any harm — and they just keep repeating that like a mantra and never address the recent restriction of these experimental practices in progressive Europe. The far right can use the issue to gin up homophobic tropes and cruel treatment of trans people.

April 5, 2020

QotD: The fear of “becoming” your job

Filed under: Education, Politics, Quotations, USA — Tags: , , , , , — Nicholas @ 01:00

In fact, “losing ourselves in the part” used to be our big worry. Maybe I am just a customer service rep …? The office, the commute, my neckties all laid out for me at the start of each week … is that really all there is to life? What happens when the long nights start taking their toll — as they must — and I have to give up the bar band? What happens when the kids grow up?

You could see this worry everywhere in our culture, our art. Watch Fast Times at Ridgemont High. Judge Reinhold’s character is wrestling with this type of question, and he’s in high school, fer chrissakes. See what I mean about that movie being made on Mars? Remember that; it’ll be on the final.

There’s a certain type of person, though, who just couldn’t grok those worries, because the very notion of social roles was incomprehensible. We didn’t know about the autism spectrum back then, but that’s what that type of person effectively is: A high-functioning autistic. For the autistic, what’s now is forever. Bob’s nametag says “customer service representative.” Therefore, Bob is a customer service representative, and only a customer service representative, now and forever. Bob the family man, Bob the stamp collector, Bob the bar-band strummer … all those fry the autistic’s circuits. It says “customer service representative,” damn it! The train is fine.

Two sides of the same coin. Normal people were worried that they were becoming their jobs. The autistics couldn’t grasp that anyone could be anything else.

The autistics all went into the ivory tower, which gave us identity politics. “Identity politics” only makes sense to the autistic — that is, to people who can’t process change. Normal people have such a hard time with it because we can’t see the logical connection between, say, being gay and being pro-abortion. I mean, if you’re gay it’s a moot point, right? Nor is there any logical connection between being gay and favoring redistributive economics, or worrying about global warming, or whatever. Maybe you do believe in redistributive economics and are worried about global warming, but those are just individual opinions, right? I’m not obliged to vote Republican because I dig blondes. It’s a non sequitur.

Not to the autistic, it isn’t. They’re told that this — pro-abortion, being “green,” the whole Liberal schmear — just is gayness, and they go with it, because that’s the only way the world makes sense to them. Just how “gay” came to mean all that is above my pay grade, but we all know it’s true. More importantly, we all know they believe it, with all their hearts and souls.

That’s the situation in which we find ourselves, my young friends, here in the Current Year. Most of us would like to be team players, but we have no role models. Because the autistics control the culture, we’ve internalized their worries. If I’m a member of the team, we instinctively feel, then somehow I am the team, and only the team, now and forever. It’s a stark choice: Either I give up my individuality completely to advance the team’s goals, or I take my ball and go home.

But it’s a false choice, kameraden, one that could only be beaten into us by very long, very expensive training — i.e. the American “education” system, K-thru-PhD.

Severian, “Advice to Young Dissidents”, Rotten Chestnuts, 2020-04-01.

June 28, 2014

Autism and vaccines infographic

Filed under: Health, Media, Science — Tags: , , — Nicholas @ 10:44

Click to see full infographic

Click to see full infographic

H/T to Nils Werner for the link.

June 23, 2014

QotD: Modern Autism

Filed under: Health, Quotations — Tags: , — Nicholas @ 00:01

There are, I believe, a few reasons to suppose that autism is a particularly fascinating area to be studying at the moment. What are those reasons? Firstly, prevalence rates of autism have soared in recent decades, from 1:2,500 in 1978 to around 1:100 today: a staggering 25-fold increase. Secondly, and simultaneously, the nature of those receiving a diagnosis of autism has changed considerably. To give just one example, in the 1980s no more than twenty percent of individuals diagnosed with autism had an I.Q. above 80. Today, by contrast, it is widely argued that “intellectual disability is not part of the broader autism phenotype… [and] the association between extreme autistic traits and intellectual disability is only modest” (Hoekstra et al. 2009: 534). Whatever you make of I.Q. scores, this changing profile means that it is reasonable to assume that when you meet somebody with autism today they are quite unlikely to be similar to someone you would’ve met with the same diagnosis just thirty years ago. Thirdly, as the number of people diagnosed with autism has increased, and as the capabilities of those individuals has increased, a (self-)advocacy network of enormous importance and influence has arisen, perhaps on a scale hitherto unseen. When woven together, these dynamic elements have led Ian Hacking to claim that, in autism, “we are participating in a living experiment in concept formation of a sort that does not come more than once in a dozen lifetimes” (Hacking 2009: 506). This, I think, is quite exciting.

Gregory Hollin, “Autism, sociality, and human nature”, Somatosphere, 2014-06-18.

April 9, 2014

QotD: “Perhaps being a boy is a learning disorder”

Filed under: Bureaucracy, Education, Health, Quotations — Tags: , , — Nicholas @ 00:01

… more children are being diagnosed with “autism spectrum disorders” than ever, specifically that diagnoses have gone from one in about a hundred and fifty to about one in sixty eight. A lot of these diagnoses are for children with extremely mild Aspergers, right at the borderline between normal (whatever that is) and Aspergers. Now this may be a result of more people suffering from ASD’s, especially extremely mild Aspergers, as a result of cumulative mutations and pregnant women being exposed to environmental risks. Or it could be that ever since the Fed’s started throwing money at diagnosing and providing educational services for kids with ASD’s they have become the diagnoses de jour. In fact, it is worth noting that since the Feds started throwing more money at ASD’s and less at ADD and ADHD the number of children diagnosed with the former has increased and the latter two decreased. Apparently getting more Federal funding causes learning/psychological disorders and getting funding cut cures them.

That or educators are blowing off the needs of kids with disorders that are not “getting the love.” My own personal opinion is that favored problems get over-diagnosed and those not blessed with Fed money get under-diagnosed. Shame on the education establishment either way.

It should also be noted that whichever disorder is getting attention it seems to hit males about four times as often as females. In fact, it seems that a lot of the descriptors of symptoms for various ASD’s and ADD read like pretty normal behavior for boys.

Perhaps being a boy is a learning disorder (there’s a large number of females who would nod their head in agreement with this thesis).

A.X. Perez, “Old News Interpreted”, Libertarian Enterprise, 2014-04-06

May 22, 2013

The controversy over the DSM-V

Filed under: Health, Science, USA — Tags: , , , , , — Nicholas @ 08:37

The science writers at The Economist discuss the American Psychiatric Association’s new Diagnostic and Statistical Manual (below the fold because it auto-plays when you load the page):

(more…)

December 16, 2012

The domestic terror: “I live with a son who is mentally ill. I love my son. But he terrifies me.”

Filed under: Health, USA — Tags: , , , , — Nicholas @ 12:39

Anarchist Soccer Mom has a story to tell. It’s neither pleasant nor uplifting, but it needs to be told:

I live with a son who is mentally ill. I love my son. But he terrifies me.

A few weeks ago, Michael pulled a knife and threatened to kill me and then himself after I asked him to return his overdue library books. His 7 and 9 year old siblings knew the safety plan — they ran to the car and locked the doors before I even asked them to. I managed to get the knife from Michael, then methodically collected all the sharp objects in the house into a single Tupperware container that now travels with me. Through it all, he continued to scream insults at me and threaten to kill or hurt me.

That conflict ended with three burly police officers and a paramedic wrestling my son onto a gurney for an expensive ambulance ride to the local emergency room. The mental hospital didn’t have any beds that day, and Michael calmed down nicely in the ER, so they sent us home with a prescription for Zyprexa and a follow-up visit with a local pediatric psychiatrist.

We still don’t know what’s wrong with Michael. Autism spectrum, ADHD, Oppositional Defiant or Intermittent Explosive Disorder have all been tossed around at various meetings with probation officers and social workers and counselors and teachers and school administrators. He’s been on a slew of antipsychotic and mood altering pharmaceuticals, a Russian novel of behavioral plans. Nothing seems to work.

[. . .]

When I asked my son’s social worker about my options, he said that the only thing I could do was to get Michael charged with a crime. “If he’s back in the system, they’ll create a paper trail,” he said. “That’s the only way you’re ever going to get anything done. No one will pay attention to you unless you’ve got charges.”

[. . .]

No one wants to send a 13-year old genius who loves Harry Potter and his snuggle animal collection to jail. But our society, with its stigma on mental illness and its broken healthcare system, does not provide us with other options. Then another tortured soul shoots up a fast food restaurant. A mall. A kindergarten classroom. And we wring our hands and say, “Something must be done.”

I agree that something must be done. It’s time for a meaningful, nation-wide conversation about mental health. That’s the only way our nation can ever truly heal.

God help me. God help Michael. God help us all.

H/T to Drew M. for the link.

September 25, 2012

A bit more progress in autism research

Filed under: Health, Science — Tags: , , , — Nicholas @ 10:19

An article at the Wall Street Journal discusses some recent advances in uncovering the causes of autism:

Scientists say that roughly 20% of autism cases can be linked to known genetic abnormalities, and many more may be discovered.

Pinpointing a genetic explanation can help predict whether siblings are likely to have the disorder — and even point to new, targeted treatments. Last week, for example, researchers reported that an experimental drug, arbaclofen, reduced social withdrawal and challenging behaviors in children and adults with Fragile X syndrome, the single most common genetic cause of autism.

[. . .]

Autism spectrum disorder (ASD) is a collection of conditions that can range in severity from the social awkwardness and narrow interests seen in Asperger’s to severe communication and intellectual disabilities. ASD now affects 1 in every 88 U.S. children — nearly double the rate in 2002 — according to the Center for Disease Control and Prevention.

No single blood test or brain scan can diagnose autism spectrum disorders — in part because environmental factors also play a major role. But once a child is diagnosed, on the basis of symptoms and behavioral tests, researchers can work backward looking for genetic causes.

Both the American Academy of Pediatrics and the American College of Medical Genetics recommend that all children diagnosed with ASD be tested for Fragile X Syndrome and other chromosome abnormalities. The newest tests, called chromosomal microanalysis, can identify submicroscopic deletions or duplications in DNA sequences known to be associated with autism. Together, these tests find genetic explanations for more than 10% of autism cases.

September 11, 2012

More evidence that a bit of dirt can be a healthy thing for kids

Filed under: Health, Media, Science — Tags: , , , — Nicholas @ 00:02

Matt Ridley reviews a new book by Moises Velasquez-Manoff:

In a remarkable new book, “An Epidemic of Absence,” Moises Velasquez-Manoff draws together hundreds of such studies to craft a powerful narrative carrying a fascinating argument. Infection with parasites prevents or ameliorates many diseases of inflammation. The author briefly cured his own hay fever and eczema by infecting himself with hookworms-before concluding that the price in terms of diarrhea and headaches was too high.

I’ve touched on the “hygiene hypothesis” in these pages before. In its cartoon form the argument-that in a clean world our immune system gets bored and turns on itself or on harmless pollen-isn’t very convincing. But Mr. Velasquez-Manoff makes a far subtler, more persuasive case. Parasites have evolved to damp our immune responses so that they can stay in our bodies. Our immune system evolved to expect parasites to damp it. So in a world with no parasites, it behaves like a person leaning into the wind when it drops: The system falls over.

Moreover, just as brains outsource much of their development to the outside world-the visual system is refined by visual input, the language system can only develop in a language-using society — so the immune system seems to have happily outsourced much of its regulation to friendly microbes. Without them, the immune system becomes unbalanced.

[. . .]

One of Mr. Velasquez-Manoff’s most surprising chapters is on autism, a disorder that almost exactly parallels asthma in its recent rise among affluent, urban, mainly male, disproportionately firstborn people. Better diagnosis explains perhaps half the rise, but the brains of people with autism are often inflamed, and there’s anecdotal evidence that infection with worms or viruses can tame autistic symptoms, at least temporarily.

April 23, 2012

Autism

Filed under: Health, Science — Tags: , , — Nicholas @ 08:41

Sandy Starr refutes the notion that “we are all on the autism spectrum now”:

Is autism a disorder? Is autism an identity? If you had asked me these questions a few years ago, before I became involved with the Autism Ethics Group at King’s College London, then my answer would have been a clear ‘yes’ and ‘no’ respectively. Clearly, autism is most usefully understood as a disorder. And clearly, it is not useful to understand autism as an identity.

If you were to ask me the same two questions today, then I would say exactly the same thing.
[. . .]

The whole concept of autism originates in psychopathology. Hans Asperger (after whom Asperger’s syndrome is named) talked about ‘autistic psychopathy’. Autism is found in the Diagnostic and Statistical Manual of Mental Disorders (DSM). And yet we now seem uneasy about the characterisation of autism as a disorder. Why?

For one thing, a disorder implies a lack of normal or typical function. The increasing numbers of people who are thought to warrant a diagnosis of either ‘classical’ autism, atypical autism or Asperger’s syndrome is now of a scale sufficient to make one ask whether autism is, in fact, exceptional. Only last month, there were newspaper headlines about the fact that about one per cent of schoolchildren in the UK are now recorded as having some kind of autistic spectrum disorder (double the figure from only five years previously). This was followed by the news that according to a new study by the Centres for Disease Control and Prevention, one in 88 children in the USA now have an autistic spectrum disorder (again, almost double the figure from five years previously).

We can speculate about the reasons for this recent upsurge, but, in order to understand it, I think it’s necessary to go back a little further and look at the broadening of autism through the concept of the ‘autism spectrum’, which is what has made it possible for autism to encompass high-functioning individuals such as myself. I think the potential for an unimpeded expansion of the category of autism, of the sort we are now seeing, may have already been there when autism was first conceptualised in the 1940s. It was certainly there once the notion of the ‘spectrum’ was introduced into psychiatry at the end of the 1960s.

I would argue that the category of autism has become less coherent, and consequently less meaningful and less useful, as a result of its expansion. And I think the osmosis into informal discourse and the pop culture of clinical terminology about autism has further undermined the category’s coherence. This has led to a situation where the ‘spectrum’ — once a categorical means of bringing together low- and high-functioning individuals who (arguably) have some features in common — is now routinely used to mean an uninterrupted continuum, ranging all the way from the pathological to the normal.

December 2, 2010

Autism may be linked to faulty mitochondria

Filed under: Health — Tags: , , , — Nicholas @ 00:05

A report in The Economist looks at a recent study which may explain the cause of autism:

One suggestion that does pop up from time to time is that the process which leads to autism involves faulty mitochondria. The mitochondria are a cell’s powerpacks. They disassemble sugar molecules and turn the energy thus liberated into a form that biochemical machinery can use. Mitochondrial faults could be caused by broken genes, by environmental effects, or by a combination of the two.

Nerve cells have a huge demand for energy, so a failure of the mitochondria would certainly affect them. The question is, could it cause autism? To try to find out Cecilia Giulivi of the University of California, Davis, and her colleagues studied the mitochondria of ten children, aged between two and five years, who had been diagnosed with autism. They have just published their results in the Journal of the American Medical Association.

[. . .]

The children in question were randomly selected from a previous study on autism. They were matched with ten children of similar ages and ethnic backgrounds who were developing normally. Dr Giulivi found that mitochondria from children with autism consumed far less oxygen than those from the control group. That is a sign of lower activity. One important set of enzymes — NADH oxidases — used, on average, only a third as much oxygen in autistic children as they did in non-autists, and eight of the autistic children had significantly lower NADH-oxidase activity than is normal.

The mitochondria of the autistic children also leaked damaging oxygen-rich chemicals such as hydrogen peroxide. These are a normal by-product of mitochondrial activity, but are usually mopped up by special enzymes before they can escape and cause harm — for instance, by damaging a cell’s DNA. The level of hydrogen peroxide in the cells of autistic children was twice that found in non-autists. Such high levels suggest the brains of autistic children are exposed to a lot of oxidative stress, something that would probably cause cumulative damage.

While such a mechanism may allow better treatments to be developed, it also implies that those who already suffer from autism may not benefit as much (or at all) from such treatments, as the cellular damage will be a much tougher challenge to reverse.

On the other hand, if the pattern can be detected early enough, it may allow treatment well in advance of serious damage.

February 2, 2010

The Lancet formally retracts controversial paper on Autism

Filed under: Britain, Health — Tags: , , — Nicholas @ 12:56

In a long-overdue move, British medical journal The Lancet has retracted a paper by Andrew Wakefield on links between the MMR vaccine and Autism:

The Lancet medical journal formally retracted a paper on Tuesday that caused a 12-year international battle over links between the three-in-one childhood MMR vaccine and autism.

The paper, published in 1998 and written by British doctor Andrew Wakefield, suggested the combined measles, mumps and rubella (MMR) shot might be linked to autism and bowel disease.

His assertion, since widely discredited, caused one of the biggest medical rows in a generation and led to a steep drop in the number of vaccinations in the United States, Britain and other parts of Europe, prompting a rise in cases of measles.

The knock-on effect of parents avoiding getting their children vaccinated creates opportunities for much more serious outbreaks of these diseases. Dr. Wakefield’s “research” has been harmful to the population at large for helping to create and exacerbate parents’ fears for their children, and in encouraging them to take the greater risk of not getting the MMR (and, in many cases, other vaccinations) for their kids.

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