Quotulatiousness

March 18, 2010

What if they could make smoking safer?

Filed under: Australia, Health — Tags: , , — Nicholas @ 08:38

My bet would be that the anti-smoking campaigners would still be as stridently opposed to smokers and their habit even if there were no health risks:

Australian boffins have developed a treatment which allows mice to smoke cigarettes without the usual negative health consequences. The method could potentially allow gasper-loving humans to sidestep some of the self-destructive results of their habit.

The key to the business, according to lead cig-boffin Ross Vlahos, is Granulocyte macrophage-colony stimulating factor (GM-CSF), an agent released by the lungs when they are exposed to cigarette smoke. GM-CSF causes inflammatory leukocytes to activate in the lungs, which then leads to chronic obstructive pulmonary disease (COPD) and other complaints such as “oxidative stress, emphysema, small airway fibrosis, mucus hypersecretion and progressive airflow limitation”.

Vlahos and his team at Melbourne uni decided to tackle this by the use of a blocking agent known as “anti GM-CSF”. As called for by tradition, they got hold of a group of mice and dosed half of them with the miracle smoko-proofing drug, and left the others alone. Then all the mice were given “the equivalent of nine cigarettes of smoke each day for four days”.

At the end of the test every single mouse was dead. However, this was simply because the boffins had killed them in order to examine their lungs. According to the mouse autopsies, the ones treated with “anti GM-CSF” were in much better nick than the others.

Of course, “safer” is not “safe”. This research implies that human smokers could benefit from use of this drug or similar formulations, but it doesn’t address all the health risks of smoking (chances of developing cancer appear to be the same, for example).

A rational reader would assume that this new research would be welcomed, but my belief is that anti-smoking groups will condemn it for “encouraging smokers” and call for the research to be discontinued. After all, this is a moral rather than a scientific campaign for many activists.

Full disclosure: I’m not a smoker, and never have been. I’m not particularly fond of being in smoke-filled rooms, but I do think the crusade against smoking long ago passed the health advocacy point and became mostly moralizing (see this for example).

September 30, 2009

Artificial skin

Filed under: Science — Tags: — Nicholas @ 12:53

Victor is doing some research on artificial skin for a school project, and he found this link, which he sent along to me, writing “Ghost in the Shell: Closer than we think?”.

What we’re trying to do is to interface electronic components with the human body. One of the challenges is that conventional electronics is typically made on very hard and flat surfaces. If you look at our own body we are a 3D object that is moving all around. The challenge is not only electrical but also mechanical because we need to find ways to make electronic things that can conform the body and therefore use materials that are no longer hard and brittle but materials that can be elastic, similar to our own skin, for example.

[. . .]

This is the second aspect of the project. In my group we’re looking at ways to make these prosthetic skins but there’s also this application where we’re looking at a way to use these very soft electronic devices to interface everything with the nervous system. Because the human body and particularly the nervous system is made of extremely compliant material we cannot use a silicon chip to interface directly with your nerve for a long time. What we’re doing is to use this polymer and elastomer substrate with embedded electrodes in it to connect directly with a peripheral nerve — so a nerve which is in the limb, not in the spinal cord or the brain — really in the limb, from the electrical signal from the neurons. Once we can do that then the idea would be to connect these peripheral implant directly to the prosthetic skin so that we could take the signals that are coming out of the prosthetic skin and convert them into a neuron format and feed that directly into the implant which would then communicate to the nerve and back to the brain.

July 13, 2009

When the data doesn’t support your claims, obscure it!

Filed under: Food, Science — Tags: , , — Nicholas @ 12:31

Ronald Bailey looks at the too-good-to-be-true claims made for caloric reduction as a life-extending tool:

Last week, two research teams reported to great fanfare that restricting the calories consumed by rhesus monkeys had extended their lifespans. Calorie restriction is thought to increase longevity by boosting DNA repair. The idea is that the mechanism evolved so that creatures on the verge of starvarion could live long enough to reproduce when food becomes plentiful again. But did the experiments really show the CR works?

In my earlier blogpost on the research results, I noted that some experts quoted in the New York Times were not convinced. Why? Because the difference in actual death rates between the dieting monkeys and the free feeding monkeys was not statistically significant.

This doesn’t necessarily derail the notion that calorie restriction may be associated with increased lifespan, but the way this study was performed does not appear to prove anything due to rigging of the data.

(Cross-posted to the old blog, http://bolditalic.com/quotulatiousness_archive/005577.html.)

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