Quotulatiousness

April 8, 2020

Debunking the claim that “80% of America’s drugs come from China”

Filed under: Business, China, Health, Media, USA — Tags: , , , , — Nicholas @ 03:00

Eric Boehm tries to sort out where the startling claim came from … because it’s not true:

While reading about the COVID-19 outbreak, you’ve probably encountered this particularly shocking statistic at one time or another: 80 percent of America’s pharmaceutical drug supply comes from China.

It’s a statistic that has made the rounds in right-wing publications for a while — offered as proof that China-heavy global supply chains are putting Americans at risk — but it has also popped up in mainstream outlets, including in pieces published in Politico and The Atlantic. Wherever it is deployed, the stat carries an unstated implication: What if China decides to cut us off in the middle of a pandemic? Could America face a dramatic shortage of key pharmaceutical drugs at the moment when we are most in need? And that distorted claim that says America has been too reliant on China has been seized by politicians like Sen. Josh Hawley (R–Mo.) as evidence that globalization has undermined America’s pandemic response.

[…]

How much is a lot? “In all, 80 percent of the U.S. supply of antibiotics are made in China,” [Politico contributors Doug Palmer and Finbarr Bermingham] wrote, linking back to a press release from Sen. Chuck Grassley (R–Iowa).

But that’s not what the press release says.

Grassley’s statement was publicizing a letter Grassley sent on August 9 to the Department of Health and Human Services (HHS) and the FDA, asking them to conduct more inspections of foreign drug manufacturing facilities to make sure they meet American standards.

“Unbeknownst to many consumers … 80 percent of Active Pharmaceutical Ingredients are produced abroad, the majority in China and India,” Grassley wrote.

There’s the first bit of context collapse: the authors of the Politico piece merged Grassley’s “80 percent … are produced abroad” into “80 percent … are made in China.”

All of this also raises another question: Where is Grassley getting that information? His letter sources that claim to a 2016 Government Accountability Office report which itself cited FDA data on pharmaceutical manufacturers around the world. And that report makes it clear that the U.S. has a diverse supply chain for drugs that goes well beyond India and China.

“Nearly 40 percent of finished drugs and approximately 80 percent of active pharmaceutical ingredients (API) are manufactured in registered establishments in more than 150 countries,” is how the GAO summed up America’s pharmaceutical supply chain.

In two jumps, we’ve gone from “80 percent of American drugs are manufactured in more than 150 countries around the world” to “80 percent of drugs come from two countries” to “80 percent of drugs come from China.”

Now, a further complication. The FDA only tracks drug manufacturing facilities — not the supply chains of specific drugs.

That “lack of structural transparency and available supply chain data about drugs,” researchers at the University of Minnesota researchers wrote last month, is one of the reasons why making accurate assessments about potential drug shortages is difficult. Indeed, it was this same bit of missing information that Grassley was encouraging the FDA to address back in August.

Source: FDA; Safeguarding Pharmaceutical Supply Chains in a Global Economy, October 2019.

January 18, 2020

The innovative 1720s

Filed under: Britain, Health, History — Tags: , , , — Nicholas @ 03:00

In the latest Age of Invention newsletter, Anton Howes says the real Roaring Twenties were back in the eighteenth century:

Last week I called the 1720s an era of schemes. 1720 was the year of the South Sea Company’s crash, as well as the collapse of John Law’s Mississippi Company in France. But the decade saw some oft-neglected innovations too. As I never tire of saying, Britain’s extraordinary acceleration of innovation was about all industries, not just the famous ones of cotton, coal, iron, and steam — a point that the 1720s demonstrate perfectly.

For a start, it was the decade in which smallpox began to be systematically eradicated through inoculation. Lady Mary Wortley Montagu, having observed the procedure in the Ottoman Empire, had her daughter inoculated in London following an outbreak in 1721. The same epidemic prompted the trialling of inoculation in New England, and the reports of these successes provided the statistical evidence for it to be more widely spread. Soon, through Lady Montagu’s aristocratic connections, even the royal children were being inoculated. Inoculation was still dangerous — it was decades before non-deadly cowpox was discovered to also confer immunity to smallpox — but the 1720s marked the beginning of the end for one of humanity’s greatest killers.

[…]

Most famous, however, was the search for longitude. When at sea, it was relatively easy to tell how far north or south you were, but not how far east or west. The implications for navigation were immense. William Whiston, a protégé of Newton, was in 1714 instrumental in lobbying for the creation of a substantial government prize for a solution, and spent much of the following decades trying to win it. His earliest proposal, along with the mathematician Humphrey Ditton, was for ships anchored at fixed locations to essentially shoot fireworks at fixed intervals. By comparing the difference between seeing and hearing the flashes, you might calculate your longitude (it’s actually not that dissimilar to the principle that underlies GPS).

Marine chronometer “Copie No. 18″, Thomas Mudge, Jr., Robert Pennington, Richard Pendleton, et al, London, 1795 – Mathematisch-Physikalischer Salon, Dresden.
Photo by Daderot via Wikimedia Commons.

But unlike with the medical advances, the poets were having none of it. As one of them rather crudely put it:

    The longitude miss’d on
    By wicked Will Whiston;
    And not better hit on
    By good master Ditton.
    So Ditton and Whiston
    May both be bepist on;
    And Whiston and Ditton
    May both be beshit on.

Whiston and the other longitude-searchers also investigated using the earth’s magnetic variation — he produced perhaps the first map with isogonic lines, indicating where compass needles dipped — as well as solar eclipses. And as longitude could be found on land by looking at the eclipses of Jupiter’s moons, he tried to develop telescopes so that they could observe such events on the unsteady sea.

Nonetheless, the solution came from one of George Graham’s friends, the clockmaker John Harrison. Starting in the 1720s, Harrison developed a timekeeping device — the marine chronometer — that would keep its accuracy despite the rocking and rolling and atmospheric changes from being at sea. By comparing your local time with the time at Greenwich shown on the chronometer, you could calculate your longitude. (Though by the time his device came into use in the 1770s, another method had been discovered that involved observing the moon).

And of particular interest to woodworkers who also have historical interests:

While scientific minds sought the longitude, consumer items were also being transformed. In the 1720s, a ship’s carpenter to Jamaica, Robert Gillow, was among the first to import mahogany to Britain, creating a tradition of furniture-making in Lancaster that even the fashion-conscious French would come to regard jealously.

November 18, 2019

Fungus rock – the great placebo treasure (and the Mujahideen)

Filed under: Europe, Health, History — Tags: , , , , — Nicholas @ 02:00

Lindybeige
Published 5 Jun 2015

Support me on Patreon: https://www.patreon.com/Lindybeige

The things that people valued and fought over in the past were not as they are now. You might not guess the tremendous significance of one tiny island off the coast of Gozo.

NEWS FLASH (March 8th 2017): the Azure Window, featured in this video, has collapsed into the sea.

More videos from Malta to follow.

Lindybeige: a channel of archaeology, ancient and medieval warfare, rants, swing dance, travelogues, evolution, and whatever else occurs to me to make.

▼ Follow me…

Twitter: https://twitter.com/Lindybeige I may have some drivel to contribute to the Twittersphere, plus you get notice of uploads.

website: http://www.LloydianAspects.co.uk

Fungus rock – the great placebo treasure

April 30, 2019

You Will Never Do Anything Remarkable

Filed under: Health, History, Humour, Space — Tags: , , , , — Nicholas @ 06:00

exurb1a
Published on 28 Apr 2019

Illegitimi non carborundum, yo.

So.
The original line was, “If they give you ruled paper, write the other way.” As far as I can tell it’s Juan Ramón Jiménez’s.

I am also now painfully aware I’ve written a half as ‘2/1’. Sorry maths.

Please note that this wasn’t intended to be a diatribe against critics or experts. They obviously play an important role. It was more directed at the recreational cynicism one comes across in daily life from time to time, generally pointed at young artists. I have had the privilege to meet plenty of people 1000x more talented than me, who are simultaneously doubting their abilities because of some stupid comment made by an unpleasant teacher or jaded family member.

If you are that artist, I really just wanted to say: You’re in good company; the Greats doubted themselves too. Don’t let the bastards get you down and I hope you make all manner of interesting and fantastic things.

The music is the 3rd movement of Big Baus Brahms’ Violin Concerto in D Major: https://youtu.be/Ev45Knhdlp8

I like that piece lots. I hope you do too.

Again, all the very best of luck in your projects.

February 11, 2019

Tuberculosis – A Ten-Thousand Year Battle – Extra History – #2

Filed under: Health, History, Science — Tags: , , — Nicholas @ 04:00

Extra Credits
Published on 7 Feb 2019

Tuberculosis couldn’t be cured and eliminated by just one person like Dr. Robert Koch, but thanks to the collective efforts of the medical community since Koch’s time — including public health initiatives and the introduction of randomized clinical trials — TB is steadily being wiped out.

Join us on Patreon! http://bit.ly/EHPatreon

February 2, 2019

Curing Tuberculosis – The Hero Koch – Extra History – #1

Filed under: Germany, Health, History, Science — Tags: , , — Nicholas @ 04:00

Extra Credits
Published on 31 Jan 2019

Fascinatingly enough, tuberculosis was actually considered “trendy” in the Victorian era of Europe — but Dr. Robert Koch, hero of the German Empire, was convinced that he could cure it. A British writer named Arthur Conan Doyle, however, was a little skeptical, and for good reason…

Enjoy today’s extra-Extra History! Dr. Robert Koch was going to save Germany, and the rest of Europe, from tuberculosis. Maybe he would even get his own institute, like his medical rival Louis Pasteur. He knew for sure he was on to something…

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October 22, 2018

QotD: Aging gracefully

Filed under: Health, Quotations — Tags: , — Nicholas @ 01:00

Last year, for the first time, a young girl, French, offered me her seat on a crowded bus. I was surprised at how deeply I resented her. Health looms over the elderly like a threatening monsoon. No ache is innocuous. No lump or discoloured, sagging patch of body is ignorable except our toenails, which become the most sordidly repellent things in all nature. We covertly examine ourselves and our effluvia for the premonition of the dark humour that will carry us away. There is no such thing as a routine checkup. They are all life-or-death appointments.

Doctors start all their sentences with “It’s only …” But we’re not fooled. This generation is also the one that lingers longest over its departure. Death came to our grandparents with a clutched chest and a searing pain. For us it’s a slow, humiliating series of it’s onlys. What we worry about is dementia, a condition that did not exist in the popular lexicon when I was a child. Mind you, we also thought cancer was as shaming as divorce. Now Alzheimer’s is our abiding fear, the thing we can’t forget.

My chats with contemporaries are like bridge games where we try to fill in the gaps in each other’s sentences to make one coherent conversation. My dad died of Alzheimer’s. I once asked him how he was feeling: “Oh, quite well, except you know I’ve got this terrible disease, what’s its name?” So we go to the gym, we have trainers, I do Pilates. But it’s only maintenance. I’m not looking for a beach body, there’s no New Me in the cupboard; I just want one that’s supple enough to put on my own socks.

After giving up drink and drugs, I continued to smoke about 60 a day until 12 years ago and then I stopped. And people said, “Well done! How did you manage it? What willpower!”

It didn’t feel like well done. It felt like a defeat — the capitulation to fear. When I started smoking at 14 I was golden, immortal. I smoked around the world; I took pride in my ability to smoke with elegance, panache and skill. Smoking was my talent and I gave it up because I lost my nerve.

I don’t miss the cigarettes, but I do miss the me that smoked so beautifully.

A.A. Gill, “Life at 60”, Sunday Times, 2014-06-29.

August 12, 2018

1918 Flu Pandemic – The Forgotten Plague – Extra History – #6

Filed under: Health, History, WW1 — Tags: , , , — Nicholas @ 04:00

Extra Credits
Published on 11 Aug 2018

Why did everyone forget about the flu pandemic so fast? Partly because its effects were intermingled with the death and depression of World War I, and partly because we chose to forget.

June 28, 2018

Mary Seacole – II: Mother Seacole in the Crimea – Extra History

Filed under: Britain, History, Military — Tags: , , , , , — Nicholas @ 02:00

Extra Credits
Published on 16 Jan 2016

Unable to find any official sponsors, Mary Seacole decided to send herself to the Crimea. She recruited her husband’s cousin, a fellow business person, and the two of them set off for the war zone. Unlike London, where she’d met a chilly reception, Mary’s help was welcomed by the overworked doctors and suffering soldiers. She built a new version of her British Hotel and invited officers to dine or shop there, using their money to buy medical supplies and creature comforts for the poorer soldiers. She had set herself up next to the army camp, and during battles she helped provide emergency care. But when at last the city of Sevastopol fell, Mary’s medical services were no longer in much demand. She enjoyed a few months of prosperity as the soldiers celebrated their newfound time off, but in March of 1856, a treaty was signed and troops began returning home. Many of them left unpaid debts, and Mary could no longer sell her supplies, so she and her business partner were forced to return home to London and declare bankruptcy. When that news got out, the soldiers she’d cared for rallied to her aid, donating money to help pay her debts. Although Mary tried to continue serving soldiers in warzones, the government never recognized her and in the end, only her homeland of Jamaica remembered her contributions after her death. In the 2000s, her story came back to light in the United Kingdom and she was recognized in 2004 as the Greatest Black Briton.

June 27, 2018

Mary Seacole – I: A Bold Front to Fortune – Extra History

Filed under: Britain, History — Tags: , , , , — Nicholas @ 02:00

Extra Credits
Published on 9 Jan 2016

Mary Seacole treated soldiers during the Crimean War – but she took a long path to get there. She grew up in Jamaica, the daughter of a local hotel owner and a Scottish soldier. She admired her doctress mother and wanted to be like her, but she also yearned to travel and see the world. In 1821 she accepted a relative’s invitation to visit London, and turned herself from a tourist to a businesswoman by importing Jamaican food preserves. She traveled with her business for several years before returning home to Jamaica, where she married a white man named Edwin Seacole and started a general store. Their venture failed, and disaster struck: fire destroyed most of Kingstown, and both Mary’s husband and her mother died in 1843. Mary survived and rebuilt the hotel, but she set out to start a new life in Panama and was immediately greeted by a cholera epidemic. She helped contain it, and earned a reputation that helped her start her own business across the street from her half-brother’s. When word reached her that the Crimean War back in Europe needed nurses, she left her business behind and went to sign up. Both the War Office and Florence Nightingale’s expedition rejected her, but Mary determined to find her own way there.

May 13, 2018

Marie Curie in WW1 – Who Killed The Red Baron? I OUT OF THE TRENCHES

Filed under: France, Germany, History, Military, WW1 — Tags: , , — Nicholas @ 04:00

The Great War
Published on 12 May 2018

Chair of Wisdom Time!

April 30, 2018

QotD: Gandhi versus Gandhi

Filed under: History, India, Media, Quotations, Religion — Tags: , , , , — Nicholas @ 01:00

I had the singular honor of attending an early private screening of Gandhi with an audience of invited guests from the National Council of Churches. At the end of the three-hour movie there was hardly, as they say, a dry eye in the house. When the lights came up I fell into conversation with a young woman who observed, reverently, that Gandhi’s last words were “Oh, God,” causing me to remark regretfully that the real Gandhi had not spoken in English, but had cried, Hai Rama! (“Oh, Rama”). Well, Rama was just Indian for God, she replied, at which I felt compelled to explain that, alas, Rama, collectively with his three half-brothers, represented the seventh reincarnation of Vishnu. The young woman, who seemed to have been under the impression that Hinduism was Christianity under another name, sensed somehow that she had fallen on an uncongenial spirit, and the conversation ended.

At a dinner party shortly afterward, a friend of mine, who had visited India many times and even gone to the trouble of learning Hindi, objected strenuously that the picture of Gandhi that emerges in the movie is grossly inaccurate, omitting, as one of many examples, that when Gandhi’s wife lay dying of pneumonia and British doctors insisted that a shot of penicillin would save her, Gandhi refused to have this alien medicine injected in her body and simply let her die. (It must be noted that when Gandhi contracted malaria shortly afterward he accepted for himself the alien medicine quinine, and that when he had appendicitis he allowed British doctors to perform on him the alien outrage of an appendectomy.) All of this produced a wistful mooing from an editor of a major newspaper and a recalcitrant, “But still …” I would prefer to explicate things more substantial than a wistful mooing, but there is little doubt it meant the editor in question felt that even if the real Mohandas K. Gandhi had been different from the Gandhi of the movie it would have been nice if he had been like the movie-Gandhi, and that presenting him in this admittedly false manner was beautiful, stirring, and perhaps socially beneficial.

Richard Grenier, “The Gandhi Nobody Knows”, Commentary, 1983-03-01.

April 19, 2018

Freedom of speech and scientific inquiry

Filed under: Liberty, Science — Tags: , , , — Nicholas @ 03:00

Adam Perkins on the critical importance of free speech in the scientific world:

A quick Google search suggests that free speech is a regarded as an important virtue for a functional, enlightened society. For example, according to George Orwell: “If liberty means anything at all, it means the right to tell people what they do not want to hear.” Likewise, Ayaan Hirsi Ali remarked: “Free speech is the bedrock of liberty and a free society, and yes, it includes the right to blaspheme and offend.” In a similar vein, Bill Hicks declared: “Freedom of speech means you support the right of people to say exactly those ideas which you do not agree with”.

But why do we specifically need free speech in science? Surely we just take measurements and publish our data? No chit chat required. We need free speech in science because science is not really about microscopes, or pipettes, or test tubes, or even Large Hadron Colliders. These are merely tools that help us to accomplish a far greater mission, which is to choose between rival narratives, in the vicious, no-holds-barred battle of ideas that we call “science”.

For example, stomach problems such as gastritis and ulcers were historically viewed as the products of stress. This opinion was challenged in the late 1970s by the Australian doctors Robin Warren and Barry Marshall, who suspected that stomach problems were caused by infection with the bacteria Helicobacter pylori. Frustrated by skepticism from the medical establishment and by difficulties publishing his academic papers, in 1984, Barry Marshall appointed himself his own experimental subject and drank a Petri dish full of H. pylori culture. He promptly developed gastritis which was then cured with antibiotics, suggesting that H. pylori has a causal role in this type of illness. You would have thought that given this clear-cut evidence supporting Warren and Marshall’s opinion, their opponents would immediately concede defeat. But scientists are only human and opposition to Warren and Marshall persisted. In the end it was two decades before their crucial work on H. pylori gained the recognition it deserved, with the award of the 2005 Nobel Prize in Physiology or Medicine.

From this episode we can see that even in situations where laboratory experiments can provide clear evidence in favour of a particular scientific opinion, opponents will typically refuse to accept it. Instead scientists tend cling so stubbornly to their pet theories that no amount of evidence will change their minds and only death can bring an end to the argument, as famously observed by Max Planck:

    A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die, and a new generation grows up that is familiar with it.

March 9, 2018

Bad news about the Peltzman Effect and opiate use

Filed under: Health, USA — Tags: , , , — Nicholas @ 03:00

Megan McArdle recounts the US federal government’s attempt to improve automobile safety in the 1960s and the surprisingly mixed results of those efforts on overall safety for drivers (better), pedestrians (worse) and the frequency of non-fatal accidents (higher). Those results were summarized by Sam Peltzman as indicating that most of us have an innate tendency to take more risks when we’re less likely to suffer the costs of those risks (hence, the “Peltzman Effect”). She then talks about a tragic new instance of this in the opiate crisis:

A chemical called naloxone acts as an “opioid antagonist” — which is to say, it reverses the drug’s effects on the body. It can thus save people who have overdosed.

As opioid usage has worsened in the United States, more and more jurisdictions have acted to increase access to naloxone. Not only first responders but also friends, family and even librarians have started to administer it. These state laws were passed at different times, giving researchers Jennifer Doleac and Anita Mukherjee a sort of a natural experiment: They could look at what happened to overdoses in areas that liberalized naloxone access and compare the trends there to places that hadn’t changed their laws.

Their results are grim, to say the least: “We find that broadening Naloxone access led to more opioid-related emergency room visits and more opioid-related theft, with no reduction in opioid-related mortality.”

You can never assume that the results of one study, however well done, are correct. But these results look pretty robust. If they hold up, they would mean that naloxone is not saving lives; all we’re doing is spending a lot of money on naloxone to generate some increase in crime.

It makes a certain amount of sense that the Peltzman Effect would show up particularly strongly in drug users; after all, drugs hijack the brain’s reward system, redirecting it toward drug-seeking even at high personal risk. Drug users, one would think, would be highly likely to recalibrate their risk-taking so that the risk of death remains constant, while the frequency and potency of drug use increases.

The coldly logical response to this would seem to be to discontinue naloxone use. But there’s something repulsive about that conclusion, and Doleac and Mukherjee can’t bring themselves to go there. “Our findings do not necessarily imply that we should stop making Naloxone available to individuals suffering from opioid addiction,” they write, “or those who are at risk of overdose. They do imply that the public health community should acknowledge and prepare for the behavioral effects we find here.”

February 18, 2018

The legal loophole that allows profiteering scumbags like Martin Shkreli to gouge the public

Filed under: Bureaucracy, Business, Government, Health, USA — Tags: , , — Nicholas @ 03:00

The US pharmaceutical market is a long way from a freely competitive environment, largely due to the amount of regulatory oversight required by lawmakers and enforced by the Food and Drug Administration (FDA). Among all the regulatory checks and balances, there’s one weird trick that allows predatory companies to reap excess profits legally — the “restricted distribution” loophole:

For immunocompromised adult patients who have the toxoplasmosis parasite, the FDA recommends taking 50 to 75 milligrams of Daraprim a day for up to three weeks, followed by half that dosage for an additional four to five weeks. So at the high end, an adult course of Daraprim therapy for a U.S. patient used to cost around $1,350 total.

While that might not seem cheap, it was a drop in the bucket compared to the cost after Turing Pharmaceuticals, Shkreli’s company, bought the rights to Daraprim and jacked the price up to $750 per pill in 2015. That move increased the cost of one course of treatment to around $75,000.

At that point you might have expected another company to jump in and start offering a generic version of the drug. But Shkreli used a regulatory loophole to keep that from happening.

You see, when a generic manufacturer wants to create a cheap version of a branded drug, it has to buy thousands of doses from the manufacturer in order to run comparison tests. Generic manufacturers use the results of these tests to prove to the FDA that their version is identical to the branded drug that the agency has already approved.

More often than not, the company that holds the marketing and distribution rights to a branded drug will sell those comparison doses to the generic manufacturer without being obstructionist, because that’s the trade-off for receiving a 20-year monopoly by way of a drug patent: The branded manufacturer gets to charge whatever they want for years and years without facing competition, and in exchange for that government-backed monopoly, it’s supposed to sell equivalency samples to generic companies.

But what if the company is run by an unscrupulous asshole like Martin Shkreli? Then it might opt to put the drug into what’s called “restricted distribution,” which means no distributor anywhere can sell comparison samples to a generic manufacturer.

The FDA originally created the concept of restricted distribution to limit the availability of drugs that might be dangerous. Methadone, for instance, was first approved in the 1940s as a painkiller. In the 1970s, the FDA restricted its availability because regulators didn’t want the opioid used for anything other than the treatment of opioid dependence. Even today, methadone can be dispensed only in highly regulated settings and only for one approved reason.

In 2007, Congress empowered the FDA to create an entire system of safety controls beyond restricted distribution, and the agency now requires the manufacturers of certain substances to develop Risk Evaluation and Mitigation Strategies (REMS) to prevent misuse and abuse of potentially problematic compounds.

The list of approved drugs that the FDA says must have an REMS is here. Daraprim is not on that list. You can’t get high off it. It’s not habit forming. Yes, the FDA label says it can be carcinogenic after long periods of use, and that it might cause birth defects if used in high doses by pregnant women. These potential effects are serious, but there is no post-market data suggesting that Daraprim is causing more harm than benefit in the intended patient population. Shkreli’s company put Daraprim into restricted distribution to boost their profits, not protect patients.

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