Quotulatiousness

October 16, 2013

Cocaine and heroin are less addictive than Oreos

Filed under: Food, Health, Science — Tags: , , — Nicholas @ 13:51

in lab rats, anyway:

“Research Shows Oreos Are Just As Addictive As Drugs,” says the headline above a recent Connecticut College press release. “…in Lab Rats,” it adds, and I’ll get to that part later. But first note that the study’s findings could just as truthfully be summarized this way: “Drugs Are No More Addictive Than Oreos.” The specific drugs included in the study were cocaine and morphine, which is what heroin becomes immediately after injection. So the headline also could have been: “Research Shows That Heroin and Cocaine Are No More Addictive Than Oreos.” Putting it that way would have raised some interesting questions about the purportedly irresistible power of these drugs, which supposedly justifies using force to stop people from consuming them.

[…]

So what exactly did the rats do? They favored the side of a maze where they were given Oreos to the same extent that they favored that side of the maze when they were given an injection of cocaine or morphine there. Furthermore, when the researchers “used immunohistochemistry to measure the expression of a protein called c-Fos, a marker of neuronal activation, in the nucleus accumbens, or the brain’s ‘pleasure center,'” they found that “the Oreos activated significantly more neurons than cocaine or morphine.” Given the latter finding, perhaps we should credit Connecticut College’s publicity department with restraint for not announcing that Oreos are in fact more addictive than cocaine or heroin. Or to put it another way: Cocaine and heroin are less addictive than Oreos. Which makes you wonder why people go to prison for selling the drugs but not for selling the cookies, especially since Oreos and similar foods “may present even more of a danger.”

The idea that people can take or leave cocaine or heroin in the same way they can take or leave Oreos seems inconsistent with research that supposedly shows how powerfully reinforcing these substances are. Studies published between 1969 and 1985, for instance, found that rats and rhesus monkeys “will prefer cocaine to food” and “will self-administer cocaine until death or near-death,” as Stanton Peele and Richard DeGrandpre note in a 1998 Addiction Research article. But the animals in these studies were isolated from other animals, deprived of interesting stimuli, and prevented from engaging in normal behavior while tethered to catheters providing “an unlimited, direct flow of high concentrations of cocaine at all times at little or no cost” (in terms of effort). Research conducted in more naturalistic settings finds that monkeys and rats are much more apt to consume cocaine and morphine in moderation.

Laboratory animals’ tendency to consume drugs to excess when they are bored and lonely has pretty clear parallels in human behavior. But unlike rats and monkeys, humans are capable of reason and foresight (even if they do not always exercise those faculties) as well as emotions such as guilt and regret. They also have considerable control over their own environments. If the reinforcing power of drugs is not the only factor in addiction among rats and monkeys, it surely is not a complete explanation for why some people get hooked on these substances while most do not.

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