Quotulatiousness

March 18, 2010

What if they could make smoking safer?

Filed under: Australia, Health — Tags: , , — Nicholas @ 08:38

My bet would be that the anti-smoking campaigners would still be as stridently opposed to smokers and their habit even if there were no health risks:

Australian boffins have developed a treatment which allows mice to smoke cigarettes without the usual negative health consequences. The method could potentially allow gasper-loving humans to sidestep some of the self-destructive results of their habit.

The key to the business, according to lead cig-boffin Ross Vlahos, is Granulocyte macrophage-colony stimulating factor (GM-CSF), an agent released by the lungs when they are exposed to cigarette smoke. GM-CSF causes inflammatory leukocytes to activate in the lungs, which then leads to chronic obstructive pulmonary disease (COPD) and other complaints such as “oxidative stress, emphysema, small airway fibrosis, mucus hypersecretion and progressive airflow limitation”.

Vlahos and his team at Melbourne uni decided to tackle this by the use of a blocking agent known as “anti GM-CSF”. As called for by tradition, they got hold of a group of mice and dosed half of them with the miracle smoko-proofing drug, and left the others alone. Then all the mice were given “the equivalent of nine cigarettes of smoke each day for four days”.

At the end of the test every single mouse was dead. However, this was simply because the boffins had killed them in order to examine their lungs. According to the mouse autopsies, the ones treated with “anti GM-CSF” were in much better nick than the others.

Of course, “safer” is not “safe”. This research implies that human smokers could benefit from use of this drug or similar formulations, but it doesn’t address all the health risks of smoking (chances of developing cancer appear to be the same, for example).

A rational reader would assume that this new research would be welcomed, but my belief is that anti-smoking groups will condemn it for “encouraging smokers” and call for the research to be discontinued. After all, this is a moral rather than a scientific campaign for many activists.

Full disclosure: I’m not a smoker, and never have been. I’m not particularly fond of being in smoke-filled rooms, but I do think the crusade against smoking long ago passed the health advocacy point and became mostly moralizing (see this for example).

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